| A Case of Multiple Myeloma with AL Amyloidosis Successfully Treated with Autologous Stem Cell Transplantation |
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Ha-young Lee1, Kyung Hee Lee1, Min Kyoung Kim1, Hee Soon Cho2, Myung Soo Hyun1 |
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea |
| 자가 조혈모세포 이식으로 치료된 전신 아밀로이드증을 동반한 다발성 골수종 1 예 |
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이하영1, 이경희1, 김민경1, 조희순2, 현명수1 |
1영남대학교 의과대학 내과학교실
2영남대학교 의과대학 진단검사의학과학교실 |
Correspondence:
Myung Soo Hyun, Tel: (053) 620-3837, Fax: (053) 654-8386,
Email: hms@med.yu.ac.kr
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| Abstract |
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Myeloma is a disease of neoplastic B lymphocytes that synthesize abnormal amounts of immunoglobulin (Ig) or Ig fragments. Ten to twenty percent of myeloma patients are known to develop clinical evidence of amyloid-light chain(AL) amyloidosis. A high index of suspicion, however, is needed to make a diagnosis of amyloidosis. We report a case of multiple myeloma with AL amyloidosis successfully treated with autologous stem cell transplantation. In our case, the patient presented with longstanding abdominal discomfort and anterior chest pain. Chest X-ray showed several osteolytic changes on ribs. Endoscopic biopsy revealed massive amyloid deposits in the wall of stomach and rectum. Serum/urine protein electroporesis and bone marrow biopsy confirmed the diagnosis of multiple myeloma. At 18 months after high dose chemotherapy and autologous stem cell transplantation(ASCT), the patient maintained a complete response. In patients with multiple myeloma with AL amyloidosis, high dose chemotherapy and ASCT can be effective treatment strategy. |
| Key Words:
Amyloidosis, Multiple myeloma, Stem cell transplantation |
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