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J Yeungnam Med Sci > Volume 24(2 Suppl); 2007 > Article
Yeungnam University Journal of Medicine 2007;24(2 Suppl):S676-682.
DOI:    Published online December 31, 2007.
A Case of Multiple Myeloma with AL Amyloidosis Successfully Treated with Autologous Stem Cell Transplantation
Ha-young Lee1, Kyung Hee Lee1, Min Kyoung Kim1, Hee Soon Cho2, Myung Soo Hyun1
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea
자가 조혈모세포 이식으로 치료된 전신 아밀로이드증을 동반한 다발성 골수종 1 예
이하영1, 이경희1, 김민경1, 조희순2, 현명수1
1영남대학교 의과대학 내과학교실
2영남대학교 의과대학 진단검사의학과학교실
Correspondence:  Myung Soo Hyun, Tel: (053) 620-3837, Fax: (053) 654-8386, 
Myeloma is a disease of neoplastic B lymphocytes that synthesize abnormal amounts of immunoglobulin (Ig) or Ig fragments. Ten to twenty percent of myeloma patients are known to develop clinical evidence of amyloid-light chain(AL) amyloidosis. A high index of suspicion, however, is needed to make a diagnosis of amyloidosis. We report a case of multiple myeloma with AL amyloidosis successfully treated with autologous stem cell transplantation. In our case, the patient presented with longstanding abdominal discomfort and anterior chest pain. Chest X-ray showed several osteolytic changes on ribs. Endoscopic biopsy revealed massive amyloid deposits in the wall of stomach and rectum. Serum/urine protein electroporesis and bone marrow biopsy confirmed the diagnosis of multiple myeloma. At 18 months after high dose chemotherapy and autologous stem cell transplantation(ASCT), the patient maintained a complete response. In patients with multiple myeloma with AL amyloidosis, high dose chemotherapy and ASCT can be effective treatment strategy.
Key Words: Amyloidosis, Multiple myeloma, Stem cell transplantation


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