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Gun Oh Chong 1 Article
Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count
Hyun-Hwa Cha, Jong Mi Kim, Hyun Mi Kim, Mi Ju Kim, Gun Oh Chong, Won Joon Seong
Yeungnam Univ J Med. 2021;38(1):34-38.   Published online June 18, 2020
DOI: https://doi.org/10.12701/yujm.2020.00234
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  • 3 Citations
AbstractAbstract PDF
Background
We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes.
Methods
We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test.
Results
The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r=−0.126, p=0.016).
Conclusion
We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes.

Citations

Citations to this article as recorded by  
  • Relationship between Platelet-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Spontaneous Preterm Birth: A Systematic Review and Meta-analysis
    Liang Peng, Baodi Cao, Fangpeng Hou, Baolin Xu, Hong Zhou, Luyi Liang, Yu Jiang, Xiaohui Wang, Jingjian Zhou, Lingzhang Meng
    Journal of Immunology Research.2023; 2023: 1.     CrossRef
  • Evaluation of Complete Blood Cell Count Parameters in the Diagnosis of Threatened Preterm Labor and Premature Rupture of Membranes
    Jule Eriç Horasanlı, Elifsena Canan Alp, Ramazan Bülbül
    Dubai Medical Journal.2022; 5(3): 157.     CrossRef
  • The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis
    Sina Vakili, Parham Torabinavid, Reza Tabrizi, Alireza Shojazadeh, Nasrin Asadi, Kamran Hessami, Oleh Andrukhov
    Mediators of Inflammation.2021; 2021: 1.     CrossRef

JYMS : Journal of Yeungnam Medical Science