Journal of Yeungnam Medical Science

Original article

Association between dental amalgam restoration and urine mercury concentrations among young women: a cross-sectional study: Su-Bin Park, Eun-Kyong Kim, Joon Sakong, Eun Young Park; J Yeungnam Med Sci. 2023;40(4):373-380. Published online March 21, 2023; DOI: https://doi.org/10.12701/jyms.2022.00955

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Abstract PDF: Background
The association between dental amalgam fillings and urine mercury concentrations was investigated in this study to assess the health risks associated with dental amalgams.
Methods
This cross-sectional study included 99 women in their 20s who visited the dental clinic in Daegu, Korea. The 99 participants were composed of 68 subjects who had dental amalgam fillings (exposure group) and 31 subjects who did not have dental amalgam fillings (nonexposure group). Oral examinations were conducted by a single dental hygienist, sociodemographic features were investigated as confounding variables, and urine mercury concentrations were measured using an automatic mercury analyzer.
Results
The mean±standard deviation of the urine mercury concentrations of the exposure and nonexposure groups were 1.50±1.78 μg/g creatinine and 0.53±0.63 μg/g creatinine, respectively. The exposure group showed significantly higher levels than the nonexposure group (p<0.01). The urine mercury concentration significantly increased with an increase in the number of teeth filled with amalgam, cavity surfaces involved, and number of defective amalgam fillings, and according to the latest exposure time (p<0.001). In the multiple regression analysis of amalgam-related factors and urine mercury concentrations after correction for confounding factors, the urine mercury concentration in the group with six or more amalgam-filled teeth, 11 or more cavity surfaces, and two or more defective amalgams was significantly higher than that in the nonexposure group (p<0.001).
Conclusion
According to this study, exposure to dental amalgams was confirmed to significantly affect urine mercury concentrations.

Review

Health Effects of Mercury Exposure through Fish.: Joon Sakong; Yeungnam Univ J Med. 2011;28(2):105-115. Published online December 31, 2011; DOI: https://doi.org/10.12701/yujm.2011.28.2.105

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4 Crossref

Mercury is atoxic, persistent pollutant that bioaccumulates and biomagnifies through food webs. People are exposed to methylmercury mainly through their diet, especially through the consumption of freshwater and marine fish and of other animals that consumefish (e.g., marinemammals). All humans are exposed to low levels of mercury. Dietary patterns can increase exposure toafish-eating population wherethefish and seafood arecontaminated with mercury. The primary toxicity targets of mercury and mercury compounds are the nervous system, kidneys, and cardiovascular system. It is generally accepted that developing organ systems are most sensitive to the toxic effects of mercury. The fetal-brain mercury levels appear to be significantly higherthan the maternal-blood mercury levels,and the developingcentralnervoussystem of the fetus is currently regarded as the main system of concern as it demonstrates the greatest sensitivity. The subpopulation that may be at greater risk for mercury toxicity are those exposed to higher levels of methylmercury due to carnivorous fish, including sharks.

Citations

Citations to this article as recorded by

Association between Blood Mercury and Seafood Consumption in Korean Adults: KoNEHS Cycle 4 (2018~2020)
Ji-Eun Oh, Tae-Hyeong Kim, Eun-Hee Lee
Biomedical Science Letters.2024; 30(1): 24. CrossRef
어패류의 구매 및 소비 패턴에 따른 소비자 영양, 위생, 안전 인식 분석
용희 석, 민준 이, 성희 민, 선희 채, 선옥 함
Korean Journal of Food and Cookery Science.2023; 39(4): 288. CrossRef
Women, Environment, and Health
박은교, 하은희, 김규연
JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH.2014; 18(1): 54. CrossRef
Reference levels of blood mercury and association with metabolic syndrome in Korean adults
Sang-Yong Eom, Sun-Hee Choi, Su-Ju Ahn, Dong-Kyeong Kim, Dong-Won Kim, Ji-Ae Lim, Byung-Sun Choi, Hye-Jung Shin, Sin-Weon Yun, Hae-Jung Yoon, Yu-Mi Kim, Young-Seoub Hong, Yong-Woon Yun, Seok-Joon Sohn, Heon Kim, Kyung-Su Park, Hee-Soo Pyo, Ho Kim, Se-Youn
International Archives of Occupational and Environmental Health.2014; 87(5): 501. CrossRef

Case Report

A Case of Mercury Intoxication Associated with Pernicious Anemia.: Kyoung Ae Chang, Hyun Do Kim, Sun Jung Mun, Dong Hee Kim, Sung Ho Chun, Ha Young Lee, Dong Woon Bae, Hee Soon Cho, Kyung Hee Lee, Myung Soo Hyun; Yeungnam Univ J Med. 2006;23(1):103-107. Published online June 30, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.1.103

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Abstract PDF: Pernicious anemia is the frequent cause of megaloblastic anemia, and it is the result of a vitamin B12 deficiency due to the decrease or absence of intrinsic factor (IF) because of gastric mucosa atrophy or autoimmune destruction of IF-producing parietal cells. With the existence of a severe gastric atrophy, there is a decreased in acid and IF production and a further change in vitamin B12 absorption. Mercury is ubiquitous in nature and exists in 3 forms, elemental mercury, inorganic salts and organic compounds. Organic forms, specifically methyl mercury, are the most toxic of the 3 classes of mercurials. Methyl mercury exerts its most devastating effect on the central nervous system by causing psychiatric disturbances, ataxia, visual loss, hearing loss, and neuropathy. We report a case of mercury intoxication associated with pernicious anemia. The 77 years old patient was referred to Yeungnam University Hospital for tongue pain, somatitis, headache and aggressive behavior. He had taken an unevaluated medicine for a long time. After clinical evaluation, this case was diagnosed as a pernicious anemia and the unevaluated medicine was made up of mercury. After the administration of D-penicillamine and intramuscular injection of BAL and cobalamine, clinical symptoms and aggressive behavior were improved as well as laboratory findings.

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