Journal of Yeungnam Medical Science

Original article

Patient outcomes and prognostic factors associated with colonic perforation surgery: a retrospective study: Do-bin Lee, Seonhui Shin, Chun-Seok Yang; J Yeungnam Med Sci. 2022;39(2):133-140. Published online October 29, 2021; DOI: https://doi.org/10.12701/yujm.2021.01445

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Background
Despite advances in surgery and intensive perioperative care, fecal peritonitis secondary to colonic perforation is associated with high rates of morbidity and mortality. This study was performed to review the outcomes of patients who underwent colonic perforation surgery and to evaluate the prognostic factors associated with mortality.
Methods
A retrospective analysis was performed on 224 consecutive patients who underwent emergency colonic perforation surgery between January 2008 and May 2019. We divided the patients into survivor and non-survivor groups and compared their surgical outcomes.
Results
The most common cause of colon perforation was malignancy in 54 patients (24.1%), followed by iatrogenic perforation in 41 (18.3%), stercoral perforation in 39 (17.4%), and diverticulitis in 37 (16.5%). The sigmoid colon (n=124, 55.4%) was the most common location of perforation, followed by the ascending colon, rectum, and cecum. Forty-five patients (20.1%) died within 1 month after surgery. Comparing the 179 survivors with the 45 non-survivors, the patient characteristics associated with mortality were advanced age, low systolic blood pressure, tachycardia, organ failure, high C-reactive protein, high creatinine, prolonged prothrombin time, and high lactate level. The presence of free or feculent fluid, diffuse peritonitis, and right-sided perforation were associated with mortality. In multivariate analysis, advanced age, organ failure, right-sided perforation, and diffuse peritonitis independently predicted mortality within 1 month after surgery.
Conclusion
Age and organ failure were prognostic factors for mortality associated with colon perforation. Furthermore, right-sided perforation and diffuse peritonitis demonstrated a significant association with patient mortality.

Citations

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Colorectal Oncologic Emergencies
Joshua Sullivan, Alec Donohue, Shaun Brown
Surgical Clinics of North America.2024; 104(3): 631. CrossRef
One Year of Experience Managing Peritonitis Secondary to Gastrointestinal Perforation at a Tertiary Care Hospital: A Retrospective Analysis
Muhammad Hasaan Shahid, Faisal I Khan, Zain Askri, Arslan Asad, M. Azhar Alam, Danish Ali, Rabia Saeed, Aun Jamal, Tauseef Fatima, M. Farooq Afzal
Cureus.2022;[Epub] CrossRef
Risk factors for urgent complications of colorectal cancer
S. N. Shchaeva
Pelvic Surgery and Oncology.2022; 12(2): 28. CrossRef

Case report

Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia: Min Kyu Kang, Hee Jung Kwon, Min Cheol Kim; Yeungnam Univ J Med. 2020;37(3):246-249. Published online April 10, 2020; DOI: https://doi.org/10.12701/yujm.2020.00094

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Abstract PDF: Synchronous gastric cancer and adenomatous colorectal polyp in patients with Klebsiella pneumoniae-induced pyogenic liver abscess (KP-PLA) and bacteremia is a rare presentation. A 58-year-old man with a 6-month history of diabetes mellitus (DM) presented with febrile sensation and dull abdominal pain in the right upper quadrant of the abdomen. Subsequent to laboratory test results and abdominal computed tomography findings, KP-PLA with bacteremia was diagnosed. After intravenous antibiotic administration, his symptoms improved, and upper endoscopy and colonoscopy were performed to evaluate the cause of KP-PLA. Biopsy specimens of the prepyloric anterior wall revealed a moderately differentiated adenocarcinoma. Endoscopic mucosal resection of the colon revealed high-grade dysplasia. Early gastric cancer (EGC) and adenomatous colorectal polyps with high-grade dysplasia concomitant with KP-PLA and bacteremia were diagnosed in our patient who had DM. Intravenous antibiotic treatment for KP-PLA, subtotal gastrectomy for EGC, and colonoscopic mucosal resection for the colon polyp were performed. After 25 days of hospitalization, subtotal gastrectomy with adjacent lymph node dissection was performed. Follow-up ultrasound imaging showed resolution of the abscess 5 weeks post-antibiotic treatment, as well as no tumor metastasis. Upper gastrointestinal endoscopy and colonoscopy should be performed to evaluate gastric cancer in patients with PLA or bacteremia, accompanied with DM or an immunocompromised condition.

Review articles

Function of hepatocyte growth factor in gastric cancer proliferation and invasion: Sung Ae Koh, Kyung Hee Lee; Yeungnam Univ J Med. 2020;37(2):73-78. Published online February 20, 2020; DOI: https://doi.org/10.12701/yujm.2019.00437

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Abstract PDF

Cancer incidence has been increasing steadily and is the leading cause of mortality worldwide. Gastric cancer is still most common malignancy in Korea. Cancer initiation and progression are multistep processes involving various growth factors and their ligands. Among these growth factors, we have studied hepatocyte growth factor (HGF), which is associated with cell proliferation and invasion, leading to cancer and metastasis, especially in gastric cancer. We explored the intercellular communication between HGF and other surface membrane receptors in gastric cancer cell lines. Using complimentary deoxyribonucleic acid microarray technology, we found new genes associated with HGF in the stomach cancer cell lines, NUGC-3 and MKN-28, and identified their function within the HGF pathway. The HGF/N-methyl-N’-nitroso-guanidine human osteosarcoma transforming gene (c-MET) axis interacts with several molecules including E-cadherin, urokinase plasminogen activator, KiSS-1, Jun B, and lipocalin-2. This pathway may affect cell invasion and metastasis or cell apoptosis and is therefore associated with tumorigenesis and metastasis in gastric cancer.

Citations

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Progress and prospects of biomarker-based targeted therapy and immune checkpoint inhibitors in advanced gastric cancer
Zhu Zeng, Qing Zhu
Frontiers in Oncology.2024;[Epub] CrossRef
Reciprocal Regulation of Cancer-Associated Fibroblasts and Tumor Microenvironment in Gastrointestinal Cancer: Implications for Cancer Dormancy
Shih-Hsuan Cheng, Hsin-Ying Clair Chiou, Jiunn-Wei Wang, Ming-Hong Lin
Cancers.2023; 15(9): 2513. CrossRef
Expression of E-cadherin and N-cadherin in Epithelial-to-Mesenchymal Transition of Osteosarcoma: A Systematic Review
Leo Issagholian, Ethan Tabaie, Akshay J Reddy, Muhammad S Ghauri, Rakesh Patel
Cureus.2023;[Epub] CrossRef
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Srilakshmi Srinivasan, Thomas Kryza, Jyotsna Batra, Judith Clements
Nature Reviews Cancer.2022; 22(4): 223. CrossRef
Identification of hub pathways and drug candidates in gastric cancer through systems biology
Seyed Reza Salarikia, Mohammad Kashkooli, Mohammad Javad Taghipour, Mahdi Malekpour, Manica Negahdaripour
Scientific Reports.2022;[Epub] CrossRef
Signaling pathways and therapeutic interventions in gastric cancer
Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng, Yihang Pan, Zhe-Sheng Chen, Yulong He
Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef
Proteomic Signatures of Diffuse and Intestinal Subtypes of Gastric Cancer
Smrita Singh, Mohd Younis Bhat, Gajanan Sathe, Champaka Gopal, Jyoti Sharma, Anil K. Madugundu, Neha S. Joshi, Akhilesh Pandey
Cancers.2021; 13(23): 5930. CrossRef

Endoscopic features aiding the diagnosis of gastric mucosa-associated lymphoid tissue lymphoma: Byung Sam Park, Si Hyung Lee; Yeungnam Univ J Med. 2019;36(2):85-91. Published online February 26, 2019; DOI: https://doi.org/10.12701/yujm.2019.00136

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Abstract PDF

The incidence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is increasing worldwide, but the diagnosis is difficult. Most patients are asymptomatic or complain of nonspecific gastrointestinal symptoms. As the endoscopic features of gastric MALT lymphoma are variable and nonspecific, the possibility of this condition may be overlooked during esophagogastroduodenoscopy, and it remain undiagnosed. Therefore, this condition needs to be considered when an abnormal mucosa is observed during this procedure. Biopsy performed during endoscopy is the primary diagnostic test, but false negative results are possible; large numbers of samples should be collected from both normal and abnormal mucosae. Endoscopic ultrasonography is useful to assess the depth of invasion and to predict the treatment response. After treatment, follow-up tests are required every 3 months until complete remission is achieved, and annually thereafter. Early diagnosis of gastric MALT lymphoma is difficult, and its diagnosis and follow-up require wide experience and competent endoscopic technique.

Citations

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Эндоскопическая семиотика гастритоподобной формы первичных неходжкинских лимфом желудка
Валерия Витальевна Лозовая, О. А. Малихова, А. О. Туманян
Clinical Oncohematology.2024; 16(4): 380. CrossRef
Uncommon presentation of gastric mucosa-associated lymphoid tissue lymphoma in a 13-year-old girl: acute vomiting of blood as the initial symptom
Xinyu Jin, Xin Jin, Piao Guo, Linjuan Lu, Weisong Sheng, Danrong Zhu
Annals of Medicine & Surgery.2024; 86(5): 3001. CrossRef
Next-Generation-Sequencing of the Human B-Cell Receptor Improves Detection and Diagnosis and Enhances Disease Monitoring in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Chidimma Agatha Akpa, Cora Husemann, Chris Allen, Ann-Christin von Brünneck, Jana Ihlow, Michael Hummel
Journal of Molecular Pathology.2024; 5(3): 292. CrossRef
A rare case of perforated gastric lymphoma presenting a life-threatening condition: A case report
Mohamed Zayati, Mohamed Ali Chaouch, Ahmed Hadj Taieb, Besma Gafsi, Mehdi Ben Abdelwahed, Faouzi Noomen
International Journal of Surgery Case Reports.2023; 112: 109010. CrossRef
Development and evaluation of a double-check support system using artificial intelligence in endoscopic screening for gastric cancer
Hirotaka Oura, Tomoaki Matsumura, Mai Fujie, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Mamoru Tokunaga, Tatsuya Kaneko, Yushi Imai, Tsubasa Oike, Yuya Yokoyama, Naoki Akizue, Yuki Ota, Kenichiro Okimoto, Makoto Arai, Yuki Nakagawa, Mari Inada,
Gastric Cancer.2022; 25(2): 392. CrossRef
Mucosa-associated lymphoid tissue lymphoma in the terminal ileum: A case report
Vitor Lauar Pimenta de Figueiredo, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Cristiano Claudino Oliveira, Eduardo Guimarães Hourneaux de Moura
World Journal of Gastrointestinal Endoscopy.2022; 14(3): 176. CrossRef
Mucosa-associated lymphoid tissue lymphoma in the terminal ileum: A case report
Vitor Lauar Pimenta de Figueiredo, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Cristiano Claudino Oliveira, Eduardo Guimarães Hourneaux de Moura
World Journal of Gastrointestinal Endoscopy.2022; 14(3): 177. CrossRef
Gastrointestinal Tract Lymphoma
Ji Yong Ahn
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 18. CrossRef
Mucosa-Associated Lymphoid Tissue Lymphoma Masked as Gastric Varices With Acute Upper Gastrointestinal Bleeding: A Case Report
David E Jonason, Michael Linden, Guru Trikudanathan
Cureus.2022;[Epub] CrossRef
Endoscopic submucosal dissection for protruding Helicobacter pylori-negative mucosa-associated lymphoid tissue lymphoma of the stomach: a case report
Mayuko Seya, Osamu Dohi, Katsuma Yamauchi, Hayato Fukui, Hajime Miyazaki, Takeshi Yasuda, Ken Inoue, Naohisa Yoshida, Yukiko Morinaga, Yoshito Itoh
Clinical Journal of Gastroenterology.2022; 15(5): 881. CrossRef
Multimodality imaging findings of infection-induced tumors
Moataz Soliman, Nicholas Guys, Peter Liu, Mariam Moshiri, Christine O. Menias, Vincent M. Mellnick, Hatice Savas, Mohamed Badawy, Khaled M. Elsayes, Ayman H. Gaballah
Abdominal Radiology.2022; 47(11): 3930. CrossRef
Does endoscopic submucosal dissection have its place in the treatment of patients with gastric mucosa associated lymphoid tissue lymphoma localized disease after eradication?
Y Li, Z Wang, X Zhang, J Yang
Acta Gastro Enterologica Belgica.2022; 85(2): 410. CrossRef
Multiple Synchronous Mucosa-Associated Lymphoid Lymphomas Involving in the Stomach, Duodenum, Ileum, and Sigmoid
Chun-Wei Chen, Yang-Yuan Chen, Yung-Fang Chen
Diagnostics.2022; 12(12): 3150. CrossRef
Gastric Mucosa-Associated Lymphoid Tissue Lymphomas Diagnosed by Jumbo Biopsy Using Endoscopic Submucosal Dissection: A Case Report
Jian Han, Jun Wang, Hua-ping Xie
Frontiers in Medicine.2021;[Epub] CrossRef
Pedunculated mucosa-associated lymphoid tissue (MALT) lymphoma causing gastric outlet obstruction
Elena Resina Sierra, Pablo Miranda García, Magdalena Adrados, Cecilio Santander Vaquero
Revista Española de Enfermedades Digestivas.2021;[Epub] CrossRef
Primary mucosal-associated lymphoid tissue extranodal marginal zone lymphoma of the bladder from an imaging perspective: A case report
Zhen-Zhen Jiang, Yuan-Yuan Zheng, Chuan-Ling Hou, Xia-Tian Liu
World Journal of Clinical Cases.2021; 9(32): 10024. CrossRef

Case report

Rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer: Eunjung Kong, Sung Ae Koh, Won Jae Kim; Yeungnam Univ J Med. 2019;36(2):159-162. Published online February 15, 2019; DOI: https://doi.org/10.12701/yujm.2019.00129

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Abstract PDF

The most cases with orbital metastases have been reported in patients with a prior established diagnosis of cancer and widespread systemic involvement. However, ocular symptoms can be developed as an initial presentation of cancer in patients without cancer history. We report a case of rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer.

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Neoplastic nerve lesions
Deep K. Patel, Kelly G. Gwathmey
Neurological Sciences.2022; 43(5): 3019. CrossRef

Case Reports

Deep vein thrombosis caused by malignant afferent loop obstruction.: Eun Gyu Kang, Chan Kim, Jeungeun Lee, Min Uk Cha, Joo Hoon Kim, Seo Hwa Park, Man Deuk Kim, Do Yun Lee, Sun Young Rha; Yeungnam Univ J Med. 2016;33(2):166-169. Published online December 31, 2016; DOI: https://doi.org/10.12701/yujm.2016.33.2.166

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Abstract PDF: Afferent loop obstruction following gastrectomy is a rare but fatal complication. Clinical features of afferent loop obstruction are mainly gastrointestinal symptoms. A 56-year-old female underwent radical total gastrectomy with Roux-en-Y esophagojejunostomy for treatment of advanced gastric cancer. After fourteen months postoperatively, she showed gradual development of edema of both legs. Computed tomography (CT) scan showed disease progression at the jejunojejunostomy site and consequent dilated afferent loop, which resulted in inferior vena cava (IVC) compression. A drainage catheter was placed percutaneously into the afferent loop through the intrahepatic duct and an IVC filter was placed at the suprarenal IVC, and selfexpanding metal stents were inserted into bilateral common iliac veins. With these procedures, sympotms related with afferent loop obstruction and deep vein thrombosis were improved dramatically. The follow-up abdominal CT scan was taken 3 weeks later and revealed the completely decompressed afferent loop and improved IVC patency. Surgical treatment should be considered as the first choice for afferent loop obstruction; however, because it is more immediate and less invasive, non-surgical modalities, such as percutaneous catheter drainage or stent placement, can be effective alternatives for inoperable cases or risky patients who have severe medical comorbidities.

Heterotopic bone formation in normal gastric cardiac mucosa.: Seok Hyeon Eom, Chang Hwan Park, Duk Won Chung, Sang Hyeok Lee, Ji Young Seo, Yeong Sung Kim, Dong Hyup Kwak, Jung Hee Kim; Yeungnam Univ J Med. 2016;33(2):146-149. Published online December 31, 2016; DOI: https://doi.org/10.12701/yujm.2016.33.2.146

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Abstract PDF: Heterotopic bone formation in the gastrointestinal tract is a rare phenomenon. Most reported cases were associated with benign and malignant neoplasms, except for a case in which heterotopic bone formation was found in a patient with Barrett's esophagus. The exact pathogenesis of the disease has not yet been established. However, most heterotopic bones found in the gastrointestinal tract were associated with mucinproducing tumors of the appendix, colon, and rectum. Inflammation may also play a role in osseous metaplasia in a case with bone formation at the base of an ulcer in Barrett's esophagus. Here, we report on a patient with heterotopic bone formation in normal gastric cardiac mucosa. A 50-year-old female visited our hospital for a routine health examination. She had no gastrointestinal symptoms, and her physical examination, blood test, X-ray, urine, and stool examination results were normal. A 0.3 cm sized polypoid lesion located just below the squamocolumnar junction was observed on upper gastrointestinal endoscopy. A piece of biopsy was taken. Histologically, a lamella bone trabecula and chronic inflammatory cells were observed in the gastric cardiac mucosa. The follow-up endoscopy performed one month later showed no residual lesion.

A Case of Gastric Glomus Tumor.: Jin Sung Lee, Sun Taek Choi, Hyun Uk Lee, Byung Jin Kwon, Ji Eun Lee, Si Hyung Lee; Yeungnam Univ J Med. 2011;28(2):165-172. Published online December 31, 2011; DOI: https://doi.org/10.12701/yujm.2011.28.2.165

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Abstract PDF: Gastric glomus tumor is a rare mesenchymal tumor that originates from modified smooth muscle cells of the glomus body. Glomus tumors are commonly observed in peripheral soft tissue, such as dermis or subungal region, but rarely in the gastrointestinal tract. A 39-year-old woman was admitted due to epigastric soreness. Upper gastrointestinal endoscopy revealed a subepithelial mass measuring 3.5cm with central ulceration at the lesser curvature-posterior wall of the antrum. Characteristically, contrast enhanced abdominal computed tomography scan demonstrated high enhancement of the submucosal mass up to the same level of the abdominal aorta in the arterial phase; this enhancement persisted to delayed phase. Due to the risk of bleeding and malignancy, wedge resection of the submucosal tumor was performed. Histologic findings were compatible with a glomus tumor.

Atypical Cerebellar Medulloblastoma Originating from Tentorium: Case Report.: Seong Ho Kim, Chang Hwan Kim, Oh Lyong Kim, Chul Hoon Chang, Sang Woo Kim, Byung Yon Choi, Soo Ho Cho, Jeong Ok Hah; Yeungnam Univ J Med. 2007;24(2):311-314. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.311

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Abstract PDF

The extraaxial presentation of a medulloblastoma is rare. This article describes the case of a 12-year-old boy who presented with severe headache, nausea, and vomiting. The tumor developed in the left tentorium; it was misdiagnosed as a meningioma based on the radiology examination. We review the literature and discuss the atypical presentation of medulloblastoma.

Citations

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New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma
Francia Y. Fang, Jared S. Rosenblum, Winson S. Ho, John D. Heiss
Cancers.2022; 14(9): 2285. CrossRef

Supratentorial Leptomeningeal Hemangioblstoma －Case Report－: Han Won Jang, Woo Mok Byun, Jae Kyo Lee, Jae Ho Cho, Kil Ho Cho, Mi Soo Hwang, Bok Hwan Park, Joon Hyuk Choi; Yeungnam Univ J Med. 2007;24(2 Suppl):S770-774. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S770

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Abstract PDF

Hemangioblastoma is a benign tumor that most commonly occurs in the cerebellum and associated with von Hippel-Lindau (VHL) disease. Supratentorial hemanigoblastomas are exceptionally rare. We describe the magnetic resonance imaging (MRI) and histopathologic findings of a supratentorial leptomeningeal hemangioblastoma.

Citations

Citations to this article as recorded by

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review
Juan Francisco Sánchez-Ortega, Marta Claramonte, Mónica Martín, Juan Calatayud-Pérez
Surgical Neurology International.2021; 12: 394. CrossRef
Supratentorial hemangioblastomas in von Hippel–Lindau wild-type patients – case series and literature review
Luís Rocha, Carolina Noronha, Ricardo Taipa, Joaquim Reis, Mário Gomes, Ernesto Carvalho
International Journal of Neuroscience.2018; 128(3): 295. CrossRef
Meningeal Supratentorial Hemangioblastoma in a Patient with Von Hippel-Lindau Disease Mimicking Angioblastic Menigioma
Hoon Kim, Ik-Seong Park, Kwang Wook Jo
Journal of Korean Neurosurgical Society.2013; 54(5): 415. CrossRef
Supratentorial hemangioblastoma: clinical features, prognosis, and predictive value of location for von Hippel-Lindau disease
S. A. Mills, M. C. Oh, M. J. Rutkowski, M. E. Sughrue, I. J. Barani, A. T. Parsa
Neuro-Oncology.2012; 14(8): 1097. CrossRef

Review Article

Role of Radiation Therapy in Treatment of Stomach Cancers: Sang Mo Yun, Myung Se Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S245-251. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S245

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Abstract PDF: Although occasionally used as a therapeutic modality, radiotherapy was not a routine part of the treatment of stomach cancer. As a single modality, preoperative radiotherapy showed some benefit, but this was not confirmed in radomized trial. In recent neoadjuvant trials, radiotherapy is usually given concurrently with chemotherapy, and pathologic complete response rates was about 30%. There were small studies of radiotherapy as an adjuvant, either alone or with chemotherapy, but the randomized studies using postoperative radiotherapy alone did not show a survival benefit. The results of intergroup gastric adjuvant trial(INT 0116) were presented in May 2000 at American Society of Clinical Oncology. In that report, postoperative concurrent chemoradiotherapy showed survival benefit. INT 0116 has established postoperative chemoradiotherapy as the standard care for high risk patients with resected stomach cancer. But, INT 0116 had several weak points including lack of standardized nodal dissection and delivery rates of treatments. So, Asian and European investigators did not agree. Korean study showed benefit of postoperative chemoradiotherapy after D2 dissection, but this study was not randomized. Recently, Korean investigators started randomized trial of chemoradiotherapy in D2 dissected patients. This trial may give answer to us about the benefit of postoperative chemoradiotherapy in resected stomach cancer.

Case Report

A Clinicopathologic Review of Eight Cases of Chondroblastoma.: Joon Hyuk Choi, Hae Jeong Choi, Mi Jin Ku, Dae Hong Suh, Duk Seop Shin, Kil Ho Cho; Yeungnam Univ J Med. 1998;15(2):359-370. Published online December 31, 1998; DOI: https://doi.org/10.12701/yujm.1998.15.2.359

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Abstract PDF: Eight cases of chondroblastoma were studied by analyzing the clinical and pathologic findings. The age of eight cases ranged from 17 to 38 years old(median age, 22.7 years old). The tumors developed in the femur (3 cases), patella (2 cases), tibia( 1 case), fibula (1 case), and ulna (1 case). The mean diameter of tumors was 4.0 cm (range, 1.5 to 8.0 cm). Grossly, tumors showed grayish brown solid area with foci of secondary aneurysmal bone cyst. Histologically, the tumor cells were round or polygonal in shape with nuclear groove. And there were chondroid differentiation(7 cases), mitosis(3 cases), calcific deposits(3 cases), secondary aneurysmal bone cyst(4 cases), hemosiderin deposits(4 cases), necrosis(3 cases), vascular invasion(1 caes) and foamy histiocytes and cholesterol cleft(1 cases). All cases showed no metastasis to lymph node and distant organ. Seven cases (87.5 %) were immunoreactive for S-100 protein. None were immunoreactive for cytokeratin.

Original Article

Neuroblastoma : Computed Tomographic Finding.: Jae Woon Kim, Jong Oh Choi, Jae Ho Cho, Mi Soo Hwang, Bok Hwan Park; Yeungnam Univ J Med. 1996;13(1):134-140. Published online June 30, 1996; DOI: https://doi.org/10.12701/yujm.1996.13.1.134

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Abstract PDF: Recently many studies have shown the usefulness of computed tomogram in diagnosing abdominal mass when clinical and conventional radiologic examinations fail to reveal the nature of abdominal mass or the cause of abdominal distension. To evaluate the usefulness of CT in diagnosing neuroblastoma, we retrospectively analyzed computed tomographic findings of 16 neuroblastoma patients, who pathologically proved in Yeungnam University Hospital from 1986 to 1995. The age range of the patients studied were from 8months to 18years. The most frequent sith of origin was adrenal gland and the next was retroperitioneum. The presenting symptoms were palpable mass, abdominal distension, and abdominal pain.- The viewpoints of this analysis were tumoral calcifications, midline cross, shape, margin, internal structure, contrast enhancement patterns, major vessel involvement, and lymph node involvement. ':haracteristic CT findings were 'as follows: Fine dense curvillinear calcification within the tumor(56%), midline cross(50%), lobulation(75%), well-circumscribed margin(56%), cystic degeneration(56%), heterogeneous contrast enhancement(690/o), encasement of major vessels such as aorta, IVC and celiac trunk(50%), and paraaortic lymphadenopathy(87%). We conclude that these CT findings were very common and could be helpful in diagnosting and differentiation neuroblastoma in infant and children.

Review

A study of PCNA Expression in Gastric Adenoma and Adenocarcinoma.: Mi Jin Kim, Won Hee Choi, Tae Sook Lee; Yeungnam Univ J Med. 1995;12(1):1-9. Published online June 30, 1995; DOI: https://doi.org/10.12701/yujm.1995.12.1.1

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Abstract PDF: A monoclonal antibody to PCNA, which can be used on routinely processed tissue, was applied to 25 cases of gastric adenomas and 64 cases of gastric adenocarcinomas in order to diffentiate adenoma and adenocarcinoma and also to evaluate the prognostic value in adenocarcinoma. The results were summerized as follows: The PCNA labelling index was 29.14+/-12.77% in control, 44.09+/-17.11% in adenoma and 80.15+/-10. 69 in adenocarcinoma, resulting in significant increase in adenocarcinoma compared to adenoma. In adenocarcinoma, no significant correlation was observed between PCNA labelling index and histologic grade, and there -was increased tendency of PCNA labelling index in proportion to depth of invasion without statistical significance. The PCNA index was significantly increased in advanced adenocarcinoma compared to early gastric carcinoma, and also in positive nodal metastasis group than in negative group. From above results, the PCNA stain will be able to provide a helpful method for the differential diagnosis between gastric adenoma and adenocarcinoma, and could be a useful prognostic factor in adenocarcinoma if other factors are considered together.

Original Article

Gastric mucosal damage by bile acid.: Hyun Hong Cho, Jeong Ill Suh, Keyong Hee Lee, Tae Nyeun Kim, Moon Kwan Chung, Hyun Woo Lee, Won Hee Choi, Chang Heon Yang; Yeungnam Univ J Med. 1992;9(2):342-350. Published online December 31, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.2.342

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Abstract PDF: To investigate the effect of bile acid on gastric mucosa, we performed biologic test using Sprague-Dawley rat. Mixture solution of TDCA 15mM and Hcl of pH 3 was given into stomach to one group and HCl of pH 3 was given into stomach to another group. The significant gastric mucosal change was vasodilation and edema, that was disappeared progressively. These findings suggest the bile acid and damage gastric mucosa.

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