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- Case Report Hematology Acute Myeloid Leukemia with t(8;21)(q22;q22) (AML1/ETO) in a Patient with Marked Hypocellularity and Low Blasts Count.
- Sung Ho Chun*, Hee Soon Cho, Chae Hoon Lee, Kyung Dong Kim, Min Kyoung Kim, Myung Soo Hyun, Soon Il Jung
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Journal of Yeungnam Medical Science 2007;24:85.
DOI: https://doi.org/10.12701/yujm.2007.24.1.85
Published online: June 30, 2007
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea. chscp@med.yu.ac.kr
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea. chscp@med.yu.ac.kr
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Abstract
According to the World Health Organization (WHO) classification system, cases with t(8;21)(q22;q22) should be diagnosed as acute myeloid leukemia (AML) even with a blast count of less than 20 percent in blood or bone marrow. It is an uncommon manifestation, moreover hypocellularity is rarely observed in this subtype of leukemia. Here, we report a case of t(8;21) in a patient with marked hypocellularity of less than 5 percent and a blast count of less than 20 percent. This patient responded relatively well to chemotherapy. An allogeneic bone marrow transplantation was performed with good engraftment . This case suggests that hypocellular AML with a t(8;21) has as good a prognosis as hypercellular AML with t(8;21).
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