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Kyu Chang Won 18 Articles
Risk factors affecting amputation in diabetic foot
Jun Ho Lee, Ji Sung Yoon, Hyoung Woo Lee, Kyu Chang Won, Jun Sung Moon, Seung Min Chung, Yin Young Lee
Yeungnam Univ J Med. 2020;37(4):314-320.   Published online May 6, 2020
DOI: https://doi.org/10.12701/yujm.2020.00129
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  • 10 Crossref
AbstractAbstract PDF
Background
A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU).
Methods
The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Their demographic characteristics, disease history, laboratory data, ankle-brachial index, Wagner classification, osteomyelitis, sarcopenia index, and ulcer sizes were considered as variables to predict outcome. A chi-square test and multivariate logistic regression analysis were performed to test the relationship of the data gathered. Additionally, the subjects were divided into two groups based on their amputation surgery.
Results
Out of the 351 subjects, 170 required LEA. The mean age of the subjects was 61 years and the mean duration of diabetes was 15 years; there was no significant difference between the two groups in terms of these averages. Osteomyelitis (hazard ratio [HR], 6.164; 95% confidence interval [CI], 3.561−10.671), lesion on percutaneous transluminal angioplasty (HR, 2.494; 95% CI, 1.087−5.721), estimated glomerular filtration rate (eGFR; HR, 0.99; 95% CI, 0.981−0.999), ulcer size (HR, 1.247; 95% CI, 1.107−1.405), and forefoot ulcer location (HR, 2.475; 95% CI, 0.224−0.73) were associated with risk of amputation.
Conclusion
Osteomyelitis, peripheral artery disease, chronic kidney disease, ulcer size, and forefoot ulcer location were risk factors for amputation in diabetic foot patients. Further investigation would contribute to the establishment of a diabetic foot risk stratification system for Koreans, allowing for optimal individualized treatment.

Citations

Citations to this article as recorded by  
  • Efficacy of Chinese and Western Medical Techniques in Treating Diabetic Foot Ulcers With Necrotizing Fasciitis of the Lower Leg
    Yongchong Chen, Yunzhu Wang, TaiAn Zhang, Chao Meng, Qing Li, Bohui Zhang, Kai Zhang, Chunfang Qin
    The International Journal of Lower Extremity Wounds.2024; 23(1): 70.     CrossRef
  • Classification of foot ulcers in people with diabetes: A systematic review
    Matilde Monteiro‐Soares, Emma J. Hamilton, David A. Russell, Gulapar Srisawasdi, Edward J. Boyko, Joseph L. Mills, William Jeffcoate, Fran Game
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • Renal function is highly associated with podiatric risk in diabetic patients
    Jean-Baptiste Bonnet, Ilan Szwarc, Antoine Avignon, Sébastien Jugant, Ariane Sultan
    Clinical Kidney Journal.2023; 16(11): 2156.     CrossRef
  • Risk factor analysis for diabetic foot ulcer‐related amputation including Controlling Nutritional Status score and neutrophil‐to‐lymphocyte ratio
    Yandan Zhu, Hongtao Xu, Yuzhen Wang, Xia Feng, Xinyu Liang, Liying Xu, Zhiqiang Liang, Zhongjia Xu, Yawen Li, Yi Le, Manchen Zhao, Jianfei Yang, Ji Li, Yemin Cao
    International Wound Journal.2023; 20(10): 4050.     CrossRef
  • The association between estimated glomerular filtration rate and prognosis in patients with diabetic foot osteomyelitis
    Jinghang Zhang, Dong Chen, Xuemei Li, Min Ding, Jun Xu, Meijun Wang, Bai Chang
    International Wound Journal.2022; 19(7): 1650.     CrossRef
  • Renal Function Status in Patients with Diabetes Mellitus Having Diabetic Foot Infection and Role of Antibiotics
    Shabab Hussain, . Arrham, Syeda Javeriya Saeed, Ahmad Murtaza Anwar, Asif Khan, Saifullah Brohi
    Pakistan Journal of Health Sciences.2022; : 189.     CrossRef
  • Re-understanding and focusing on normoalbuminuric diabetic kidney disease
    Na An, Bi-tao Wu, Yu-wei Yang, Zheng-hong Huang, Jia-fu Feng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial
    Mehrdad Mokhtari, Reza Razzaghi, Mansooreh Momen‐Heravi
    Phytotherapy Research.2021; 35(4): 2099.     CrossRef
  • Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study
    Michael Salim
    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
The relationship between muscle mitochondrial nutritional overloading and insulin resistance
Jae Han Jeon, Jun Sung Moon, Kyu Chang Won, In Kyu Lee
Yeungnam Univ J Med. 2017;34(1):19-28.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.19
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AbstractAbstract PDF
The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.
Adrenocorticotropic hormone (ACTH)-producing pheochromocytoma presented as Cushing syndrome and complicated by invasive aspergillosis.
Jae Ho Cho, Da Eun Jeong, Jae Young Lee, Jong Geol Jang, Jun Sung Moon, Mi Jin Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Yeungnam Univ J Med. 2015;32(2):132-137.   Published online December 31, 2015
DOI: https://doi.org/10.12701/yujm.2015.32.2.132
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  • 3 Crossref
AbstractAbstract PDF
Adrenocorticotropic hormone (ACTH)-producing pheochromocytoma has been rarely reported, whereas only a few cases of Cushing syndrome accompanied by opportunistic infections have been reported. We experienced a patient with pheochromocytoma with ectopic Cushing syndrome complicated by invasive aspergillosis. A 35-year-old woman presented with typical Cushingoid features. Her basal plasma cortisol, ACTH, and 24-hour urine free cortisol levels were significantly high, and 24-hour urine metanephrine and catecholamine levels were slightly elevated. The endogeneous cortisol secretion was not suppressed by either low- or high-dose dexamethasone. Abdominal computed tomography (CT) revealed a heterogeneous enhancing mass measuring approximately 2.5 cm in size in the left adrenal gland. No definitive mass lesion was observed on sellar magnetic resonance imaging. On fluorine-18 fluorodeoxyglucose positron emission tomography/CT, a hypermetabolic nodule was observed in the left upper lung. Thus, we performed a percutaneous needle biopsy, which revealed inflammation, not malignancy. Thereafter, we performed a laparoscopic left adrenalectomy, and its pathologic finding was a pheochromocytoma with positive immunohistostaining for ACTH. After surgery, the biochemistry was normalized, but the clinical course was fatal despite intensive care because of the invasive aspergillosis that included the lungs, retina, and central nervous system.

Citations

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  • Ectopic ACTH- and/or CRH-Producing Pheochromocytomas
    Patrick F Elliott, Thomas Berhane, Oskar Ragnarsson, Henrik Falhammar
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(2): 598.     CrossRef
  • Ectopic adrenocorticotrophic hormone syndrome (EAS) with phaeochromocytoma: a challenging endocrine case with a happy ending
    Sharifah Faradila Wan Muhamad Hatta, Leoni Lekkakou, Ananth Viswananth, Harit Buch
    BMJ Case Reports.2019; 12(8): e230636.     CrossRef
  • Severe Cushing Syndrome Due to an ACTH-Producing Pheochromocytoma: A Case Presentation and Review of the Literature
    Jenan N Gabi, Maali M Milhem, Yara E Tovar, Emhemmid S Karem, Alaa Y Gabi, Rodhan A Khthir
    Journal of the Endocrine Society.2018; 2(7): 621.     CrossRef
A Case of Pancytopenia with Hyperthyroidism.
Tae Hoon Kim, Ji Sung Yoon, Byung Sam Park, Dong Won Lee, Jae Ho Cho, Jun Sung Moon, Eui Hyun Kim, Kyu Chang Won, Hyoung Woo Lee
Yeungnam Univ J Med. 2013;30(1):47-50.   Published online June 30, 2013
DOI: https://doi.org/10.12701/yujm.2013.30.1.47
  • 2,068 View
  • 16 Download
  • 3 Crossref
AbstractAbstract PDF
There has been an increase in the number of reports of atypical manifestations of Graves' disease (GD), such as jaundice, anemia, thrombocytopenia and leukopenia. Pancytopenia also rarely occurs in GD. In this paper, a case of pancytopenia with GD that was successfully treated with an anti-thyroid drug is reported. In this case, a 69-year-old woman showed pancytopenia with a normal peripheral blood smear, bone marrow aspiration smear and bone marrow biopsy. Her thyroid function test and thyroid scintigraphy confirmed her hyperthyroid status. Her laboratory abnormality and clinical condition improved after she was treated with an anti-thyroid drug. This is a rare case of pancytopenia associated with GD.

Citations

Citations to this article as recorded by  
  • Therapeutic plasma exchange for Graves’ disease in pregnancy
    Matthew Lumchee, Mimi Yue, Josephine Laurie, Adam Morton
    Obstetric Medicine.2023; 16(2): 126.     CrossRef
  • Non-myeloproliferative Pancytopenia: A Rare Presentation of Thyrotoxicosis
    Izzathunnisa Rahmathullah, Maheswaran Umakanth, Suranga Singhapathirane
    Cureus.2023;[Epub]     CrossRef
  • Atypical Complications of Graves’ Disease: A Case Report and Literature Review
    Khaled Ahmed Baagar, Mashhood Ahmed Siddique, Shaimaa Ahmed Arroub, Ahmed Hamdi Ebrahim, Amin Ahmed Jayyousi
    Case Reports in Endocrinology.2017; 2017: 1.     CrossRef
A Case of Functionary Cystic Parathyroid Adenoma with Papillary Thyroid Carcinoma.
Woo Jin Chang, Hyun Hee Jung, Sang Hyen Park, Se Hoon Sohn, Ji Sung Yoon, Hyoung Woo Lee, Kyu Chang Won, In Ho Cho
Yeungnam Univ J Med. 2010;27(2):139-145.   Published online December 31, 2010
DOI: https://doi.org/10.12701/yujm.2010.27.2.139
  • 1,480 View
  • 2 Download
AbstractAbstract PDF
Cystic parathyroid adenoma is one of rare causes of hyperparathyroidism, and tends to cause increased serum level of parathyroid hormone, alkaline phosphate and serum calcium level similar to when compared to those of solid adenoma.
A Case of Parathyroid Adenoma Presenting as Acute Pancreatitis Accompanied with Empty Sella.
Eon Ju Jun, Ji He O, Kyung Ryun Bae, Saet Byul Jang, Seung Woon Jun, Eui Dal Jung, Ho Sang Shon, Kyu Chang Won
Yeungnam Univ J Med. 2009;26(1):63-69.   Published online June 30, 2009
DOI: https://doi.org/10.12701/yujm.2009.26.1.63
  • 1,533 View
  • 4 Download
AbstractAbstract PDF
The incidence of coexisting hyperparathyroidism and empty sella syndrome is rare and the etiology and incidence of their coexistence is not known. The association of hyperparathyroidism and the empty sella syndrome may be related to multiple endocrine neoplasia (MEN) syndrome due to a genetic disorder. We experienced a rare case of hyperparathyroidism presenting as acute pancreatitis combined with empty sella. We report here a 37-year old female who manifested epigastric pain because of acute pancreatitis. She had hypercalcemia due to parathyroid adenoma. A pituitary gland was not visible in the sella turcica on MRI scans. On genetic analysis, she did not show a mutation of the MENIN gene. Empty sella is thought to be a coincidental finding with hyperparathyroidism.
The Diagnosis and Treatment of Osteoporosis.
Jun sung Moon, Kyu Chang Won
Yeungnam Univ J Med. 2008;25(1):19-30.   Published online June 30, 2008
DOI: https://doi.org/10.12701/yujm.2008.25.1.19
  • 2,008 View
  • 11 Download
  • 12 Crossref
AbstractAbstract PDF
Osteoporosis, a disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and fracture risk, is a major public health problem. The diagnostic methods for osteoporosis include simple radiography, bone scan, DXA (Dual energy X-ray Absortiometry) and biochemical markers of bone turnover. Optimal treatment and prevention of osteoporosis require modification of risk factors, particularly smoking cessation, adequate physical activity, and attention to diet, in addition to pharmacologic intervention. The estrogens and raloxifene both prevent bone loss in postmenopausal women, and the estrogens probably also decrease the risk of first fracture. There is good evidence that raloxifene prevents further fractures in postmenopausal women who already have had fractures and some evidence that estrogen does as well. Bisphosphonate prevents bone loss and reduces fractures in healthy and osteoporotic postmenopausal women and in osteoporotic men as well. Risedronate is more potent and has fewer side effects than alendronate and reduces the incidence of fractures in osteoporotic women. Calcitonin increases bone mineral density in early postmenopausal women and men with idiopathic osteoporosis, and also reduces the risk of new fractures in osteoporotic women. All of the agents discussed above prevent bone resorption, whereas teriparatide and strontium increase bone formation and are effective in the treatment of osteoporotic women and men. New avenues for targeting osteoporosis will emerge as our knowledge of the regulatory mechanisms of bone remodeling increases, although issues of tissue specificity may remain to be addressed.

Citations

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  • Effects of Gloiopeltis furcata Extract on Antioxidant Activity and Osteoblast Differentiation
    Jeong Hyeon Kang, Kyung Im Jung, Mi Hwa Park, Geun Hye Oh, Mihyang Kim
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(5): 450.     CrossRef
  • Effects of Herbal Medicines on Bone Mineral Density Score in Osteoporosis or Osteopenia: Study Protocol for a Systematic Review and Meta-Analysis
    Su Min Hong, Eun Jung Lee
    Journal of Korean Medicine Rehabilitation.2021; 31(2): 49.     CrossRef
  • Effects of Joaguihwan (JGH, 左歸丸) Extract on Changes of Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and on Factors Related with Bone Metabolism in Skull Fractured Rat
    Yu Chen Li, Min-seok Oh
    Journal of Korean Medicine Rehabilitation.2016; 26(3): 31.     CrossRef
  • The Effects of Long term Osteoporosis Management Education on BMD Level and Medication Compliance in Postmenopausal Women
    Dong-Hee Kim, Young-Sil Bae, Sang-Hwa Lee
    Journal of Korean Public Health Nursing.2014; 28(1): 102.     CrossRef
  • Consumption of health functional food and dietary habits, nutrient intake and dietary quality of college students in Incheon
    So Young Kim, Jeong Soon You, Kyung Ja Chang
    Korean Journal of Nutrition.2013; 46(2): 166.     CrossRef
  • The usefulness of MR subtraction technique in metastatic spinal cancer
    J-H Cho, H-K Lee, B-J Han, J Lee, K-R Dong, W-K Chung, J-Y Bae
    The Imaging Science Journal.2013; 61(5): 419.     CrossRef
  • Correlations between the MR Diffusion-weighted Image (DWI) and the bone mineral density (BMD) as a function of the soft tissue thickness-focus on phantom and patient
    Myung-Sam Kim, Jae-Hwan Cho, Hae-Kag Lee, Sang-Jeong Lee, Cheol-Soo Park, Kyung-Rae Dong, Yong-Soon Park, Woon-Kwan Chung, Jong-Woong Lee, Ho-Sung Kim, Eun-Hye Kim, Dae Cheol Kweon, Hwa-Yeon Yeo
    Journal of the Korean Physical Society.2013; 62(4): 684.     CrossRef
  • A study on quantitative analyses before and after injection of contrast medium in spine examinations performed by using diffusion weighted image
    Jae-Hwan Cho, Hae-Kag Lee, Yong- Kyun Kim, Kyung-Rae Dong, Woon-Kwan Chung, Kyu-Ji Joo
    Journal of the Korean Physical Society.2013; 62(4): 700.     CrossRef
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    Journal of the Korea Society of Computer and Information.2012; 17(9): 165.     CrossRef
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    Eng-Chan Kim, Ki-Hong Kim, Cheol-Soo Park, Sun-Yeob Lee, Heung-Joon Yoo, Jae-Hwan Cho, Hyun-Cheol Jang, Bo-Hui Kim, Man-Seok Han
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    Dong Sook Cho, Jeung Yun Lee
    Korean Journal of Women Health Nursing.2008; 14(4): 297.     CrossRef
Langerhans Cell Histiocytosis with Central Diabetes Insipidus: A Case Report.
Jin Ho Kim, Jun Sung Moon, Sun Jung Mun, Ji Eun Lee, Jae Won Choi, Mi Jung Eun, Kyung A Chun, Ihn Ho Cho, Ji Sung Yoon, Kyu Chang Won, Kyung Hee Lee, Duk Seop Shin, Hyoung Woo Lee
Yeungnam Univ J Med. 2005;22(2):259-265.   Published online December 31, 2005
DOI: https://doi.org/10.12701/yujm.2005.22.2.259
  • 1,516 View
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AbstractAbstract PDF
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain, polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased from 109 mOsmol/kg to 327 mOsmol/kg (300%). Brain MRI showed a thickened pituitary stalk and air bubble like lesions sized with 5cm, 7cm was shown on fifth L-spine and right hip bone at hip bone CT. CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes. The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
Comparison of Ga-67, Tl-201 and Tc-99m MIBI Imaging in Lymphoma Patients.
Kyung Ah Chun, Ihn Ho Cho, Kyu Chang Won, Kyung Hee Lee, Hyung Woo Lee, Myung Soo Hyun, Jae Tae Lee, Kyu Bo Lee
Yeungnam Univ J Med. 2002;19(2):107-115.   Published online December 31, 2002
DOI: https://doi.org/10.12701/yujm.2002.19.2.107
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AbstractAbstract PDF
PURPOSE: Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. MATERIALS AND METHODS: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. RESULTS: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. CONCLUSION: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.
Optimization of Correction Factor for Linearization with Tc-99m HM PAO and Tc-99m ECD Brain SPECT.
Ihn Ho Cho, Kohei Hayashida, Kyu Chang Won, Hyoung Woo Lee, Hiroshi Watabe, Norihiko Kume, Chikao Uyama
Yeungnam Univ J Med. 1999;16(2):237-243.   Published online December 31, 1999
DOI: https://doi.org/10.12701/yujm.1999.16.2.237
  • 1,371 View
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AbstractAbstract PDF
No abstract available.
Clinical Aspects in Patients with Thyrotoxic Periodic Hypokalemic Paralysis.
Sang Yob Nam, Jae Hong Kim, Jung Hyn Oh, Jin Chul Park, Hyun Dae Yoon, Kyu Chang Won, Ihn Ho Cho, Hyoung Woo Lee, Cha Kyung Sung
Yeungnam Univ J Med. 1999;16(2):228-236.   Published online December 31, 1999
DOI: https://doi.org/10.12701/yujm.1999.16.2.228
  • 1,368 View
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AbstractAbstract PDF
BACKGROUND
Thyrotoxic periodic paralysis is an uncommon illness characterized by intermittent flaccid paralysis of skeletal muscle, usually accompanied by hypokalemia, in patient with hyperthyroidism. However. the pathophysiology of thyrotoxic periodic paralysis remains largely unexplained and controversial. This report describes the clnical and biochemical findings in 19 patients with thyrotoxic periodic paralysis who were examined at the Yeungnam University Medical Center (YUMC) during the past decade. METHODS: The medical records of 997 YUMC patients, seen between 1986 and 1996, with dignosis of hyperthyroidism were reviewed. Nineteen patients out of 997 hyperthyrodism patients were diagnosed, and examined by history, physical examination, serum electrolyte value, and thyroid function test during paralysis. On the basis of these results, compasons were made on age. sex, precipitating factors, timing, affected limbs, prognosis, serum potassium and serum phosphate and thyroid hormone levels. RESULTS: the prevalence of periodic paralysis in hyperthyroidism was 1.9 percent and the male to female prevalence ratio was 30:1 and in all patients, the development of perodic paralysis was correlated with hyperfuntional state of the throid gland. Eleven cases of periodic paralysis were associated with hypokalemia and their throid hormon levels were significantly more increased than those of the patients without hypokalemia. interestingly, our study shows the recurrence of paralysis after treatment. CONCLUSION: Although the precise pathophysiology of the disease is as yet undefined and controversial, it occurs primarily in Asians with an overwhelming male preponderance and prevalence of 2 percent in hyperthyrodism. The interactive roles of thyroid hormon. Na-K pump. and genetically inherited defect in the celluar membrance potential of the skeletal muscle can be speculated. Further investigation will be neede to firmly establish the mechanism of thyrotoxic periodic paraysis.
Dual-Isotope SPECT Imaging with Thallium-201 and Technetium-99m MIBI in Detecting Coronary Artery Disease.
Gyu Gwang Lee, Ihn Ho Cho, Hyoung Woo Lee, Jong Sun Park, Kyu Chang Won, Dong Gu Sin, Young Jo Kim, Bong Sup Shim
Yeungnam Univ J Med. 1999;16(1):101-107.   Published online June 30, 1999
DOI: https://doi.org/10.12701/yujm.1999.16.1.101
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AbstractAbstract PDF
We evaluated the results of sequential SPECT dual-isotope imaging with Tl-201 and Tc-99m MIBI in 24 patients, all of whom also had coronary angiography within the past one month. Coronary angiography showed that 12 patients had no CAD, 4 patients had one-vessel CAD, 7 patients had two-vessel CAD and 1 patient had three-vessel CAD. Serial studies of resting Tl-201 and dipyridamole stress Tc-99m MIBI were completed within 2 hours. When more then 50% of coronary artery narrowing was considered significant. The overall sensitivity and specification of CAD detection were 91.7%. The sensitivity of CAD detection in patients with one-vessel and multi-vessel diseases was 75% and 100%, respectively. Therefore, sequential dual-isotope SPECT demonstrated high sensitivity and specificity of CAD detection. In conclusion, sequential dual-isotope imaging is feasible and can be completed in a short time and may therefore enhance laboratory throughput and patient convenience.
Vertebral compression fractures: distinction between benign and malignant causes with Tc-99m labeled antigranulocyte antibody immunoscintigraphy.
Ihn Ho Cho, Hyong Woo Lee, Sang Ho An, Kyu Chang Won, Jang Ho Bae, Soo Ho Cho
Yeungnam Univ J Med. 1998;15(2):254-262.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.254
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AbstractAbstract PDF
We evaluated the effectiveness of Tc-99m labeled antigranulocyte antibody immunoscintigraphy in differentiating the causes of vertebral compression fracture. This study involved 16 patients with vertebral compression fracture; 8 were due to trauma or osteoporosis, 3 were due to metastasis and 5 were due to tuberculous spondylitis. We retrospectively analyzed the location and the extent of decreased tracer uptake in tomographic images of Tc-99m labeled antigranulocyte antibody immunoscintigraphy. Eight patients had a 16 vertebral compression fractures due to trauma or osteoporosis , three patients had a 3 vertebral compression fractures due to metastasis and 5 patients had a 6 vertebral compression fractures due to tuberculous spondylitis. Sixteen vertebral compression fractures by trauma or osteoporosis showed a normal tracer uptake in pedicle, laminar and spinous process, but there was noted with 6 decreased uptake, 8 absence of tracer uptake and 2 normal tracer uptake in the vertebral body. Two vertebral compression fractures by metastasis showed the absence of uptake in vertebral body, pedicle, laminar and spinous process, and one showed an absence of vertebral body and spinous process. Six vertebral compression fractures by tuberculous spondylitis showed the absence of uptake in six compression fractures, the absence of pedicle in five compression fractures. We concluded Tc-99m labeled antigranulocyte antibody immunoscintigraphy may be helpful to differentiate the causes of vertebral compression fractures.
A Case of Parathyroid Carcinoma with Systemic Calcification.
Heui Sik Kim, Chan Woo Lee, Sang Yiup Nam, Jin Chul Park, Ji Sang Yoon, Jae Chun Lee, Kyu Chang Won, Ihn Ho Cho, Tae Nyun Kim, Hyoung Woo Lee, Myung Soo Hyun, Hyun Woo Lee
Yeungnam Univ J Med. 1997;14(2):459-466.   Published online December 31, 1997
DOI: https://doi.org/10.12701/yujm.1997.14.2.459
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  • 1 Crossref
AbstractAbstract PDF
Hyperparathyroidism due to parathyroid cancer is rare. It is difficult to diagnose preoperatively but there should be an increased index of suspicion in those parathyroid Patient with palpable neck masses, profound hypercalcemia(greater than 14mg/dl), made increase of the parathyroid hormone level to greater than twice normal, and significant metabolic complications. In parathyroid cancer, systemic calcinosis is an extremely rare manifestation. The most common metastatic calcification site is lung and the other involved site is stomach, liver, skin and heart. After resection of parathyroid tumor, this systemic calcinosis is self-limiting. We experienced a patient with primary hyperparathyroidsm, presented with metastatic calcification in the lung and stomach disappeared by successful parathyroidectomy.

Citations

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  • A Case of Parathyroid Carcinoma in a Patient with Stage 3 Chronic Kidney Disease
    Youn Hee Cho, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Jung Mi Park, Jeong Ja Kwak
    Korean Journal of Medicine.2012; 83(6): 796.     CrossRef
Estimation of Glomerular Filtration Rate(GFR) Using (99m)Tc-DTPA Renal Scan and the Parameters for Renal Function.
Ihn Ho Cho, Hyun Dae Yoon, Kyu Chang Won, Chan Woo Lee, Hyoung Woo Lee, Hyun Woo Lee
Yeungnam Univ J Med. 1994;11(1):101-108.   Published online June 30, 1994
DOI: https://doi.org/10.12701/yujm.1994.11.1.101
  • 1,855 View
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Many previously described nuclear medicine procedures to assess glomerular filtration rate have some problems because numerous blood sample is to be taken and they don't measure each separate renal function. Gates described isotopic method for the measurement of global and unilateral GFR based on the fractional renal uptake of (99m)Tc-DTPA 2 to 3 minutes after its intravenous injection. We evaluated GFR using (99m)Tc-DTPA in 57 people according to Gates method and compared with creatinine clearance. A good correlation was observed between creatinine clearance and GRF calculated by Gates' formula with an r value of 0.9(P<0.05). And also the relationship between parameters of (99m)Tc-DTPA renal scan images and GFR was taken. They were significantly correlated with GFR calculated by Gates' formula : r value 0.66 between relative intensity of peak renal to peak aortic activity(pK/pA) and GFR, -0.42 between time between aortic and kidney peak(A-K) and GFR and -0.48 between parenchymal renal activity at 25 min compared to peak kidney activity(25K/pK) and GRF. In conclusion, the determination of GFR according to Gates' formula shows good and reproducible of GRF with rapidity and simplicity. And the parameters from the renal scan images can use to estimate the renal function.
Emphysematous pyelonephritis : a case report and review of the literature.
Hyun Dae Yoon, Kyu Chang Won, Chan Woo Lee, In Ho Jo, Hyung Woo Lee, Kyung Woo Yoon, Heun Ju Lee, Hyun Woo Lee, Cheol Kyu Cho
Yeungnam Univ J Med. 1993;10(2):537-543.   Published online December 31, 1993
DOI: https://doi.org/10.12701/yujm.1993.10.2.537
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Emphysematous pyelonephritis is a necrotizing renal infections characterized by intrarenal and occasional perirenal gas production. Although uncommon (89 cases in the literature), it occurs almost exclusively in diabetic patients (87% of the cases). Prompt and aggressive management is required to sahage these patients. We describe a recent case of a diabetic woman with emphysematous pyelonephritis due to E. Coll, successfully managed with unilateral nephrectomy.
A case of SIADH in small cell lung cancer.
Kyu Chang Won, Jong Sik Lim, Chan Woo Lee, Hyoung Woo Lee, Choong Ki Lee, Jin Hong Chung, Myoung Soo Hyun, Bong Sup Shim, Hyun Woo Lee
Yeungnam Univ J Med. 1991;8(2):227-234.   Published online December 31, 1991
DOI: https://doi.org/10.12701/yujm.1991.8.2.227
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The syndrome of inappropriate ADH secretion is a disorder characterized by hyponatremia which results from water retention attributable to ADH release. The hallmark of SIADH is hyponatremia due to water retention, in the presence of urinary osmolality above plasma osmolality. The SIADH was initially described by Schwartz et al (1957). This syndrome, first recognized in patients with bronchogenic carcinoma, has now been observed in a variety of other illnesses. Recently, we encountered a 59 year-old female with small cell lung cancer, also she had SIADH. Thus, we present a case and review the literature on the subject.
Correlation between Microalbuminuria Checked by RIA & Micral-Test®.
Chan Woo Lee, Kyu Chang Won, Soo Bong Choi
Yeungnam Univ J Med. 1991;8(2):158-163.   Published online December 31, 1991
DOI: https://doi.org/10.12701/yujm.1991.8.2.158
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It is evident that an elevation of airway albumin excreation rate without clinical proteinuria strongly predicts a later progression on diabetic renal disease. So we studied the correlation between Microalbumin checkly RIA & Micral-Test®. We collected urine between 08:00 h and 08:00 h next day and then checked microalbuminuria by radioimmunoassay method and Micral-Test® The results are as follows: 1. There was significant correlation between microalbuminuria checked by RIA & Micral-Test® 2. There was poor correlation between diabetes duration or HV-A1c and maximal change in albumin excreation rate. 3. So we concluded that Micral-Test® can be used in laboratory instead of RIA.

JYMS : Journal of Yeungnam Medical Science