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Volume 36(2); May 2019
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Review articles
Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology
In Cheol Yoon, Jong Ryeol Eun
Yeungnam Univ J Med. 2019;36(2):67-77.   Published online April 11, 2019
DOI: https://doi.org/10.12701/yujm.2019.00171
  • 8,071 View
  • 196 Download
  • 4 Citations
AbstractAbstract PDF
The paradigm of chronic liver diseases has been shifting. Although hepatitis B and C viral infections are still the main causes of liver cirrhosis and hepatocellular carcinoma (HCC), the introduction of effective antiviral drugs may control or cure them in the near future. In contrast, the burden of nonalcoholic fatty liver disease (NAFLD) has been increasing for decades, and 25 to 30% of the general population in Korea is estimated to have NAFLD. Over 10% of NAFLD patients may have nonalcoholic steatohepatitis (NASH), a severe form of NAFLD. NASH can progress to cirrhosis and HCC. NASH is currently the second leading cause to be placed on the liver transplantation list in the United States. NAFLD is associated with obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. The pathophysiology is complex and associated with lipotoxicity, inflammatory cytokines, apoptosis, and insulin resistance. The only proven effective treatment is weight reduction by diet and exercise. However, this may not be effective for advanced fibrosis or cirrhosis. Therefore, effective drugs are urgently needed for treating these conditions. Unfortunately, no drugs have been approved for the treatment of NASH. Many pharmaceutical companies are trying to develop new drugs for the treatment of NASH. Some of them are in phase 2 or 3 clinical trials. Here, pharmacologic therapies in clinical trials, as well as the basic principles of drug therapy, will be reviewed, focusing on pathophysiology.

Citations

Citations to this article as recorded by  
  • Effect of Lactobacillus rhamnosus hsryfm 1301 Fermented Milk on Lipid Metabolism Disorders in High-Fat-Diet Rats
    Hengxian Qu, Lina Zong, Jian Sang, Yunchao Wa, Dawei Chen, Yujun Huang, Xia Chen, Ruixia Gu
    Nutrients.2022; 14(22): 4850.     CrossRef
  • Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease
    Yuanqiang Ma, Gyurim Lee, Su-Young Heo, Yoon-Seok Roh
    Antioxidants.2021; 11(1): 91.     CrossRef
  • Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis
    Suna Kılınç, Tuna Demirbaş, Enver Atay, Ömer Ceran, Zeynep Atay
    Obesity Research & Clinical Practice.2020; 14(2): 136.     CrossRef
  • Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides
    L. Kořínková, V. Pražienková, L. Černá, A. Karnošová, B. Železná, J. Kuneš, Lenka Maletínská
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
Trends in the study on medical education over the last 10 years, based on paper titles
Seong Yong Kim
Yeungnam Univ J Med. 2019;36(2):78-84.   Published online May 13, 2019
DOI: https://doi.org/10.12701/yujm.2019.00206
  • 4,186 View
  • 109 Download
AbstractAbstract PDF
Medical education research subjects are incredibly diverse and have changed over time. This work in particular aims to compare and analyze research trends in medical education through the words used in the titles of these research papers. Academic Medicine (the journal of the Association of American Medical Colleges), Medical Teacher (the journal of the Association of Medical Education in Europe), the Korean Journal of Medical Education (KJME), and Korean Medical Education Review (KMER) were selected and analyzed for the purposes of this research. From 2009 to 2018, Academic Medicine and Medical Teacher published approximately 10 to 20 times more papers than the KJME and KMER. Frequently used words in these titles include “medical,” “student,” “education,” and “learning.” The words “clinical” and “learning” were used relatively often (7.80% to 13.66%) in Korean Journals and Medical Teacher, but Academic Medicine used these phrases relatively less often (6.47% and 4.41%, respectively). Concern with such various topics as problem-based learning, team-based learning, program evaluations, burnout, e-learning, and digital indicates that Medical Teacher seems to primarily deal with teaching and learning methodologies, and Academic Medicine handles all aspects of medical education. The KJME and KMER did not cover all subjects, as they publish smaller papers. However, it is anticipated that research on new subjects, such as artificial intelligence in medical education, will occur in the near future.
Endoscopic features aiding the diagnosis of gastric mucosa-associated lymphoid tissue lymphoma
Byung Sam Park, Si Hyung Lee
Yeungnam Univ J Med. 2019;36(2):85-91.   Published online February 26, 2019
DOI: https://doi.org/10.12701/yujm.2019.00136
  • 8,035 View
  • 183 Download
  • 12 Citations
AbstractAbstract PDF
The incidence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is increasing worldwide, but the diagnosis is difficult. Most patients are asymptomatic or complain of nonspecific gastrointestinal symptoms. As the endoscopic features of gastric MALT lymphoma are variable and nonspecific, the possibility of this condition may be overlooked during esophagogastroduodenoscopy, and it remain undiagnosed. Therefore, this condition needs to be considered when an abnormal mucosa is observed during this procedure. Biopsy performed during endoscopy is the primary diagnostic test, but false negative results are possible; large numbers of samples should be collected from both normal and abnormal mucosae. Endoscopic ultrasonography is useful to assess the depth of invasion and to predict the treatment response. After treatment, follow-up tests are required every 3 months until complete remission is achieved, and annually thereafter. Early diagnosis of gastric MALT lymphoma is difficult, and its diagnosis and follow-up require wide experience and competent endoscopic technique.

Citations

Citations to this article as recorded by  
  • Development and evaluation of a double-check support system using artificial intelligence in endoscopic screening for gastric cancer
    Hirotaka Oura, Tomoaki Matsumura, Mai Fujie, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Mamoru Tokunaga, Tatsuya Kaneko, Yushi Imai, Tsubasa Oike, Yuya Yokoyama, Naoki Akizue, Yuki Ota, Kenichiro Okimoto, Makoto Arai, Yuki Nakagawa, Mari Inada,
    Gastric Cancer.2022; 25(2): 392.     CrossRef
  • Mucosa-associated lymphoid tissue lymphoma in the terminal ileum: A case report
    Vitor Lauar Pimenta de Figueiredo, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Cristiano Claudino Oliveira, Eduardo Guimarães Hourneaux de Moura
    World Journal of Gastrointestinal Endoscopy.2022; 14(3): 176.     CrossRef
  • Mucosa-associated lymphoid tissue lymphoma in the terminal ileum: A case report
    Vitor Lauar Pimenta de Figueiredo, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Cristiano Claudino Oliveira, Eduardo Guimarães Hourneaux de Moura
    World Journal of Gastrointestinal Endoscopy.2022; 14(3): 177.     CrossRef
  • Gastrointestinal Tract Lymphoma
    Ji Yong Ahn
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 18.     CrossRef
  • Mucosa-Associated Lymphoid Tissue Lymphoma Masked as Gastric Varices With Acute Upper Gastrointestinal Bleeding: A Case Report
    David E Jonason, Michael Linden, Guru Trikudanathan
    Cureus.2022;[Epub]     CrossRef
  • Endoscopic submucosal dissection for protruding Helicobacter pylori-negative mucosa-associated lymphoid tissue lymphoma of the stomach: a case report
    Mayuko Seya, Osamu Dohi, Katsuma Yamauchi, Hayato Fukui, Hajime Miyazaki, Takeshi Yasuda, Ken Inoue, Naohisa Yoshida, Yukiko Morinaga, Yoshito Itoh
    Clinical Journal of Gastroenterology.2022; 15(5): 881.     CrossRef
  • Multimodality imaging findings of infection-induced tumors
    Moataz Soliman, Nicholas Guys, Peter Liu, Mariam Moshiri, Christine O. Menias, Vincent M. Mellnick, Hatice Savas, Mohamed Badawy, Khaled M. Elsayes, Ayman H. Gaballah
    Abdominal Radiology.2022; 47(11): 3930.     CrossRef
  • Does endoscopic submucosal dissection have its place in the treatment of patients with gastric mucosa associated lymphoid tissue lymphoma localized disease after eradication?
    Y Li, Z Wang, X Zhang, J Yang
    Acta Gastro Enterologica Belgica.2022; 85(2): 410.     CrossRef
  • Multiple Synchronous Mucosa-Associated Lymphoid Lymphomas Involving in the Stomach, Duodenum, Ileum, and Sigmoid
    Chun-Wei Chen, Yang-Yuan Chen, Yung-Fang Chen
    Diagnostics.2022; 12(12): 3150.     CrossRef
  • Gastric Mucosa-Associated Lymphoid Tissue Lymphomas Diagnosed by Jumbo Biopsy Using Endoscopic Submucosal Dissection: A Case Report
    Jian Han, Jun Wang, Hua-ping Xie
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Pedunculated mucosa-associated lymphoid tissue (MALT) lymphoma causing gastric outlet obstruction
    Elena Resina Sierra, Pablo Miranda García, Magdalena Adrados, Cecilio Santander Vaquero
    Revista Española de Enfermedades Digestivas.2021;[Epub]     CrossRef
  • Primary mucosal-associated lymphoid tissue extranodal marginal zone lymphoma of the bladder from an imaging perspective: A case report
    Zhen-Zhen Jiang, Yuan-Yuan Zheng, Chuan-Ling Hou, Xia-Tian Liu
    World Journal of Clinical Cases.2021; 9(32): 10024.     CrossRef
Forefoot disorders and conservative treatment
Chul Hyun Park, Min Cheol Chang
Yeungnam Univ J Med. 2019;36(2):92-98.   Published online May 14, 2019
DOI: https://doi.org/10.12701/yujm.2019.00185
  • 12,181 View
  • 318 Download
  • 20 Citations
AbstractAbstract PDF
Forefoot disorders are often seen in clinical practice. Forefoot deformity and pain can deteriorate gait function and decrease quality of life. This review presents common forefoot disorders and conservative treatment using an insole or orthosis. Metatarsalgia is a painful foot condition affecting the metatarsal (MT) region of the foot. A MT pad, MT bar, or forefoot cushion can be used to alleviate MT pain. Hallux valgus is a deformity characterized by medial deviation of the first MT and lateral deviation of the hallux. A toe spreader, valgus splint, and bunion shield are commonly applied to patients with hallux valgus. Hallux limitus and hallux rigidus refer to painful limitations of dorsiflexion of the first metatarsophalangeal joint. A kinetic wedge foot orthosis or rocker sole can help relieve symptoms from hallux limitus or rigidus. Hammer, claw, and mallet toes are sagittal plane deformities of the lesser toes. Toe sleeve or padding can be applied over high-pressure areas in the proximal or distal interphalangeal joints or under the MT heads. An MT off-loading insole can also be used to alleviate symptoms following lesser toe deformities. Morton’s neuroma is a benign neuroma of an intermetatarsal plantar nerve that leads to a painful condition affecting the MT area. The MT bar, the plantar pad, or a more cushioned insole would be useful. In addition, patients with any of the above various forefoot disorders should avoid tight-fitting or high-heeled shoes. Applying an insole or orthosis and wearing proper shoes can be beneficial for managing forefoot disorders.

Citations

Citations to this article as recorded by  
  • Deep-Learning Algorithms for Prescribing Insoles to Patients with Foot Pain
    Jeoung Kun Kim, Yoo Jin Choo, In Sik Park, Jin-Woo Choi, Donghwi Park, Min Cheol Chang
    Applied Sciences.2023; 13(4): 2208.     CrossRef
  • Morton’s Extension on Hallux Rigidus Pathology
    Rubén Sánchez-Gómez, Juan Manuel López-Alcorocho, Almudena Núñez-Fernández, María Luz González Fernández, Carlos Martínez-Sebastián, Ismael Ortuño-Soriano, Ignacio Zaragoza-García, Álvaro Gómez-Carrión
    Prosthesis.2023; 5(1): 251.     CrossRef
  • Cinderella’s misery: The wretched human foot
    Cem Turaman
    The Foot.2023; 56: 101983.     CrossRef
  • The videos on YouTube® related to hallux valgus surgery have insufficient information
    Metin Uzun, Tunca Cingoz, Mehmet Emin Duran, Ali Varol, Haluk Celik
    Foot and Ankle Surgery.2022; 28(4): 414.     CrossRef
  • Diabetic Ulcer Prevention
    Melanie M. Lyon
    Physician Assistant Clinics.2022; 7(1): 13.     CrossRef
  • Effects of Custom-made Insoles on Plantar Biomechanics and Upper Extremity Muscle Performance
    Yi Xu, Qing-hua Hou, Xiu-lan Han, Chu-huai Wang, Dong-feng Huang
    Current Medical Science.2022; 42(1): 159.     CrossRef
  • Clinical evaluation of an innovative nerve termination cap for treatment and prevention of stump neuroma pain: Results from a prospective pilot clinical study
    Ryan Pereira, Damien Dauphinee, Stephen Frania, Alan Garrett, Craig Martin, Carl Van Gils, Craig Thomajan
    Foot & Ankle Surgery: Techniques, Reports & Cases.2022; 2(2): 100179.     CrossRef
  • Pathophysiological Behaviour of the Climber’s Foot versus the General Population: A Prospective Observational Study
    Paula Cobos-Moreno, Álvaro Astasio-Picado, Beatriz Gómez-Martín
    Healthcare.2022; 10(5): 868.     CrossRef
  • Selected hallmarks of hallux valgus in older women with symptomatic hallux valgus compared to middle-aged women with and without deformation of the forefoot
    Agnieszka Jankowicz-Szymańska, Katarzyna Wódka, Marta Bibro, Eliza Smoła, Aneta Bac
    Scientific Reports.2022;[Epub]     CrossRef
  • Impact of a dynamic ankle orthosis on acute pain and function in patients with mechanical foot and ankle pain
    Chloe L. Chung, Max R. Paquette, Denis J. DiAngelo
    Clinical Biomechanics.2021; 83: 105281.     CrossRef
  • Effects of Balance Shoes on Balance and Postural Stability in the Elderly: A Crossover, Controlled, Randomized Single-Blind Study
    Nicolas Amiez, Carole Cometti, Éric Mouillon, Marie José Teisseire, Pascal Chenut, Christos Paizis, Nicolas Babault
    Healthcare.2021; 9(2): 179.     CrossRef
  • Diagnosis and conservative management of great toe pathologies: a review
    Nicholas A. Andrews, Jessyca Ray, Aseel Dib, Whitt M. Harrelson, Ankit Khurana, Maninder Shah Singh, Ashish Shah
    Postgraduate Medicine.2021; 133(4): 409.     CrossRef
  • Evaluating the Symmetry in Plantar Pressure Distribution under the Toes during Standing in a Postural Pedobarographic Examination
    Karolina Gawronska, Jacek Lorkowski
    Symmetry.2021; 13(8): 1476.     CrossRef
  • Hallux Valgus Nonunion Correction in an Active Duty Military Member
    Aryan Rezvani, Kiya Shazadeh Safavi, Todd A Fellars, Cory F Janney
    Military Medicine.2021;[Epub]     CrossRef
  • Effects of rocker radii with two longitudinal bending stiffnesses on plantar pressure distribution in the forefoot
    I.Y. ten Wolde, L. van Kouwenhove, R. Dekker, J.M. Hijmans, C. Greve
    Gait & Posture.2021; 90: 457.     CrossRef
  • A Concurrent Plantar Stress Sensing and Energy Harvesting Technique by Piezoelectric Insole Device and Rectifying Circuitry
    Junliang Chen, Yanning Dai, Shuaibo Kang, Lijun Xu, Shuo Gao
    IEEE Sensors Journal.2021; 21(23): 26364.     CrossRef
  • Seated Virtual Reality-Guided Exercise Improved Gait in a Postoperative Hallux Valgus Case
    Masami Nakamoto, Akihiro Kakuda, Toshinori Miyashita, Takashi Kitagawa, Masashi Kitano, Masahiko Hara, Shintarou Kudo
    International Journal of Environmental Research and Public Health.2021; 18(24): 13267.     CrossRef
  • Reducción de las presiones plantares dinámicas en un calcetín experimental. Un estudio preliminar
    Juan Miguel Caracuel López, Raquel Sánchez Rodríguez, Beatriz Gómez-Martín, Elena Escamilla-Martínez , Alfonso Martínez Nova, Víctor Manuel Jiménez Cano
    Revista Española de Podología.2021;[Epub]     CrossRef
  • Metatarsalgia
    Francisco Vargas Negrín
    FMC - Formación Médica Continuada en Atención Primaria.2020; 27(3): 139.     CrossRef
  • A Rare Case of Lateral Forefoot Pain: Plantar Adventitious Bursitis
    Min Cheol Chang, Wei-Ting Wu, Ke-Vin Chang
    Cureus.2020;[Epub]     CrossRef
Original articles
Efficacy of ramosetron in combination with polyethylene glycol of preparing for a colonoscopy
Min Kyu Kang, Byung Ik Jang, Jun Suk Park, Kyeong Ok Kim
Yeungnam Univ J Med. 2019;36(2):99-104.   Published online December 28, 2018
DOI: https://doi.org/10.12701/yujm.2019.00080
  • 4,277 View
  • 93 Download
  • 1 Citations
AbstractAbstract PDF
Background
Because of its efficacy and safety, polyethylene glycol (PEG) is generally used to prepare for colonoscopy. However, the side effects of PEG, including nausea, vomiting, abdominal discomfort, pain, and general weakness, tend to decrease patient compliance and satisfaction. The aim of this study is to investigate the efficacy and safety of PEG with 0.1 mg ramosetron on colonoscopy patients who had difficulty taking PEG due to side effects or large volume.
Methods
From January to August in 2012, 28 patients who visited Yeungnam University hospital for a colonoscopy were prospectively enrolled. All enrolled patients were previous history underwent colonoscopy using PEG only in our hospital. The efficacy and safety of ramosetron were assessed through the use of a questionnaire, and compared previous bowel preparation.
Results
Compared to previous examination, the patients using the ramosetron reported less nausea, vomiting, abdominal discomfort, and abdominal pain, as well as a higher degree of compliance and satisfaction of the patient. There were no side effects reported with the use of ramosetron. However, overall bowel preparation quality was not better than the previous examination.
Conclusion
In case of the use of ramosetron in combination with PEG for bowel preparation, patients experienced a higher rate of compliance and tolerance. Looking forward, ramosetron may become an option of pretreatment for bowel preparation.

Citations

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  • Tolerance to colonoscopy preparation with Fortrans and predictors of negative effects
    I. A. Matveev, B. K. Gibert, A. I. Matveev, M. P. Kozlov
    Bulletin of Siberian Medicine.2021; 20(1): 83.     CrossRef
Impact of calcineurin inhibitors on rat glioma cells viability
Jeong Hun Seong, Woo Yeong Park, Jin Hyuk Paek, Sung Bae Park, Seungyeup Han, Kyo-Cheol Mun, Kyubok Jin
Yeungnam Univ J Med. 2019;36(2):105-108.   Published online January 21, 2019
DOI: https://doi.org/10.12701/yujm.2019.00108
  • 3,781 View
  • 72 Download
AbstractAbstract PDF
Background
Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of CNIs by focusing on the viability of glioma cells.
Methods
Glioma cells were treated with several concentrations of CNIs for 24 hours at 37 ℃ and their cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Results
Exposure to 0, 0.25, 0.5, 2.5, 5.0, and 10.0 mM concentrations respectively showed 100%, 64.3%, 61.3%, 68.1%, 62.4%, and 68.6% cell viability for cyclosporine and 100%, 38.6%, 40.8%, 43.7%, 37.8%, and 43.0% for tacrolimus. The direct toxic effect of tacrolimus on glioma cell viability was stronger than that of cyclosporine at the same concentration.
Conclusion
CNIs can cause neurological side effects by directly exerting cytotoxic effects on brain cells. Therefore, we should carefully monitor the neurologic symptoms and level of CNIs in kidney transplant patients.
Digital subtraction angiography vs. real-time fluoroscopy for detection of intravascular injection during transforaminal epidural block
Kibeom Park, Saeyoung Kim
Yeungnam Univ J Med. 2019;36(2):109-114.   Published online January 24, 2019
DOI: https://doi.org/10.12701/yujm.2019.00122
  • 4,405 View
  • 90 Download
  • 3 Citations
AbstractAbstract PDF
Background
Transforaminal epidural block (TFEB) is an effective treatment option for radicular pain. To reduce complications from intravascular injection during TFEB, use of imaging modalities such as real-time fluoroscopy (RTF) or digital subtraction angiography (DSA) has been recommended. In this study, we investigated whether DSA improved the detection of intravascular injection during TFEB at the whole spine level compared to RTF.
Methods
We prospectively examined 316 patients who underwent TFEB. After confirmation of final needle position using biplanar fluoroscopy, 2 mL of nonionic contrast medium was injected at a rate of 0.5 mL/s under RTF; 30 s later, 2 mL of nonionic contrast medium was injected at a rate of 0.5 mL/s under DSA.
Results
Thirty-six intravascular injections were detected for an overall rate of 11.4% using RTF, with 45 detected for a rate of 14.2% using DSA. The detection rate using DSA was statistically different from that using RTF (p=0.004). DSA detected a significantly higher proportion of intravascular injections at the cervical level than at the thoracic (p=0.009) and lumbar (p=0.011) levels.
Conclusion
During TFEB at the whole spine level, DSA was better than RTF for the detection of intravascular injection. Special attention is advised for cervical TFEB, because of a significantly higher intravascular injection rate at this level than at other levels.

Citations

Citations to this article as recorded by  
  • Thoracic transforaminal epidural steroid injection for management of thoracic spine pain: A multicenter cross-sectional study of short-term outcomes
    Josh Levin, John Chan, Lisa Huynh, Matt Smuck, Jayme Koltsov, Bilge Kesikburun, Graham E. Wagner, Marc Caragea, Keith Kuo, Zachary L. McCormick, Byron Schneider, Evan Berlin, D.J. Kennedy, Serdar Kesikburun
    Interventional Pain Medicine.2022; 1(1): 100004.     CrossRef
  • Safety of local anesthetics in cervical nerve root injections: a narrative review
    Zachary E. Stewart
    Skeletal Radiology.2022;[Epub]     CrossRef
  • The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Interventional Management of Cancer-Associated Pain
    Mansoor M Aman, Ammar Mahmoud, Timothy Deer, Dawood Sayed, Jonathan M Hagedorn, Shane E Brogan, Vinita Singh, Amitabh Gulati, Natalie Strand, Jacqueline Weisbein, Johnathan H Goree, Fangfang Xing, Ali Valimahomed, Daniel J Pak, Antonios El Helou, Priyanka
    Journal of Pain Research.2021; Volume 14: 2139.     CrossRef
Clinical significance of lymph node size in locally advanced cervical cancer treated with concurrent chemoradiotherapy
Jinju Oh, Ki Ho Seol, Youn Seok Choi, Jeong Won Lee, Jin Young Bae
Yeungnam Univ J Med. 2019;36(2):115-123.   Published online February 21, 2019
DOI: https://doi.org/10.12701/yujm.2019.00143
  • 5,250 View
  • 84 Download
  • 3 Citations
AbstractAbstract PDF
Background
This study aimed to assess the in-field lymph node (LN) failure rate according to LN size and to investigate effect of LN size on the survival outcome of patients with locally advanced cervical carcinoma treated with concurrent chemoradiotherapy (CCRT).
Methods
A total of 310 patients with locally advanced cervical carcinoma treated with CCRT were enrolled in retrospective study. LN status was evaluated by magnetic resonance imaging. All patients received conventional external beam irradiation and high-dose rate brachytherapy, and concurrent cisplatin-based chemotherapy. In-field LN failure rate according to LN size was analyzed.
Results
The median follow-up period was 83 months (range, 3-201 months). In-field LN failure rate in patients with pelvic LN size more than 10 mm was significantly higher than that in patients with pelvic LN size less than 10 mm (p<0.001). A similar finding was observed in the in-field para-aortic LN failure rate (p=0.024). The pelvic and para-aortic LN size (≥10 mm) was a significant prognostic factor of overall-survival (OS) and disease-free survival rate in univariate and multivariate analyses. The OS rate was significantly different between groups according to LN size (<10 mm vs. ≥10 mm).
Conclusion
A LN of less than 10 mm in size in an imaging study is controlled by CCRT. On the other hand, in LN of more than 10 mm in size, the in-field LN failure rate increase and the prognosis deteriorate. Therefore, a more aggressive treatment strategy is needed.

Citations

Citations to this article as recorded by  
  • Treatment of bulky lymph nodes in locally advanced cervical cancer: boosting versus debulking
    Ester Paulien Olthof, Hans Wenzel, Jacobus van der Velden, Anje M Spijkerboer, Ruud Bekkers, Jogchum J Beltman, Hans W Nijman, Brigitte Slangen, Ramon Smolders, Nienke van Trommel, Petra L M Zusterzeel, Ronald Zweemer, Lukas J A Stalpers, Maaike van der A
    International Journal of Gynecologic Cancer.2022; 32(7): 861.     CrossRef
  • Targetability of cervical cancer by magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT) for patients receiving radiation therapy
    Lifei Zhu, Yi Huang, Dao Lam, H. Michael Gach, Imran Zoberi, Dennis E. Hallahan, Perry W. Grigsby, Hong Chen, Michael B. Altman
    International Journal of Hyperthermia.2021; 38(1): 498.     CrossRef
  • Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB–IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study
    Simone Marnitz, Audrey Tieko Tsunoda, Peter Martus, Marcelo Vieira, Renato Jose Affonso Junior, João Nunes, Volker Budach, Hermann Hertel, Alexander Mustea, Jalid Sehouli, Jens-Peter Scharf, Uwe Ulrich, Andreas Ebert, Iris Piwonski, Christhardt Kohler
    International Journal of Gynecologic Cancer.2020; 30(12): 1855.     CrossRef
What are the most important prognostic factors in patients with residual rectal cancer after preoperative chemoradiotherapy?
Sol-Min Kim, Ghilsuk Yoon, An Na Seo
Yeungnam Univ J Med. 2019;36(2):124-135.   Published online April 1, 2019
DOI: https://doi.org/10.12701/yujm.2019.00157
  • 5,107 View
  • 80 Download
  • 3 Citations
AbstractAbstract PDF
Background
We aimed to establish robust histoprognostic predictors on residual rectal cancer after preoperative chemoradiotherapy (CRT).
Methods
Analyzing known histoprognostic factors in 146 patients with residual disease allows associations with patient outcome to be evaluated.
Results
The median follow-up time was 77.8 months, during which 59 patients (40.4%) experienced recurrence and 41 (28.1%) died of rectal cancer. On univariate analysis, residual tumor size, ypT category, ypN category, ypTNM stage, downstage, tumor regression grade, lymphatic invasion, perineural invasion, venous invasion, and circumferential resection margin (CRM) were significantly associated with recurrence free survival (RFS) or/and cancer-specific survival (CSS) (all p<0.005). On multivariate analysis, higher ypTNM stage and CRM positivity were identified as independent prognostic factors for RFS (ypTNM stage, p=0.024; CRM positivity, p<0.001) and CSS (p=0.022, p=0.017, respectively). Furthermore, CRM positivity was an independent predictor of reduced RFS, irrespective of subgrouping according to downstage (non-downstage, p=0.001; downstage, p=0.010) or lymph node metastasis (non-metastasis, p=0.004; metastasis, p=0.007).
Conclusion
CRM status may be as powerful as ypTNM stage as a prognostic indicator for patient outcome in patients with residual rectal cancer after preoperative CRT.

Citations

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  • Poor nutrition and sarcopenia are related to systemic inflammatory response in patients with rectal cancer undergoing preoperative chemoradiotherapy
    Shinya Abe, Hiroaki Nozawa, Kazushige Kawai, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Junko Kishikawa, Tsuyoshi Ozawa, Yuichiro Yokoyama, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Soichiro Ishihara
    International Journal of Colorectal Disease.2022; 37(1): 189.     CrossRef
  • Preoperative sarcopenia is a poor prognostic factor in lower rectal cancer patients undergoing neoadjuvant chemoradiotherapy: a retrospective study
    Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Junko Kishikawa, Hiroaki Ishii, Yuichiro Yokoyama, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Koji Oba, Soichiro Ishihara
    International Journal of Clinical Oncology.2022; 27(1): 141.     CrossRef
  • A Four-Methylated lncRNAs-Based Prognostic Signature for Hepatocellular Carcinoma
    Le-En Liao, Dan-Dan Hu, Yun Zheng
    Genes.2020; 11(8): 908.     CrossRef
Factors affecting complications after treatment of epidermal cyst
Man Ki Choi, Kyu Jin Chung
Yeungnam Univ J Med. 2019;36(2):136-140.   Published online April 1, 2019
DOI: https://doi.org/10.12701/yujm.2019.00164
  • 5,557 View
  • 85 Download
  • 2 Citations
AbstractAbstract PDF
Background
Epidermal cysts are the most common benign epithelial tumors in humans. The curative treatment of epidermal cyst is surgical excision. However, only few studies have investigated the cause and mechanism of postoperative complications of epidermal cysts. Therefore, this study aimed to evaluate the factors affecting complications of epidermal cyst after surgical treatment.
Methods
Patients with histologically diagnosed epidermal cysts were selected from among 98 consecutive patients with excised benign cystic tumors from March 2014 to August 2017. Sex, age, size, mobility, site of occurrence, history of infection, history of incision and drainage, complications, history of reoperation, and method of overcoming complications was obtained by analyzing medical records retrospectively.
Results
Five of the 98 patients had wound dehiscence due to surgical infection. Three of them underwent wound healing with conservative treatment without a second operation. The other two patients underwent a second operation and showed signs of preoperative infection. None of the factors showed statistical significance in relation to the occurrence of complications.
Conclusion
Postoperative complications occurred when the excision of the epidermal cyst was performed at preoperative infection sites or at sites with high tension, so attention should be paid to postoperative care.

Citations

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  • Intradiploic Epidermoid Cyst of the Posterior Fossa – Case Report and Review of the Literature
    Gonçalo Januário, Bruno Cunha, Ludovica Cellini, Gonçalo Novais
    Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery.2023; 42(01): e73.     CrossRef
  • Development of Multiple Epidermal Inclusion Cysts After Radiofrequency Microtenotomy for Plantar Fasciitis: A Case Report
    Jennifer Skolnik, Jane Pontious, Todd Hasenstein
    The Journal of Foot and Ankle Surgery.2021; 60(5): 1088.     CrossRef
Association between cadmium exposure and hearing impairment: a population-based study in Korean adults
Da Jung Jung
Yeungnam Univ J Med. 2019;36(2):141-147.   Published online April 15, 2019
DOI: https://doi.org/10.12701/yujm.2019.00178
  • 4,302 View
  • 78 Download
  • 1 Citations
AbstractAbstract PDF
Background
The present study aimed to evaluate the clinical association between cadmium exposure and hearing impairment among the Korean population.
Methods
This retrospective cross-sectional study used the data obtained from the Korean National Health and Nutrition Examination Survey were used for our study. Finally, 3,228 participants were included in our study, which were then divided into quartiles based on their blood cadmium levels: first quartile (1Q), second quartile (2Q), third quartile (3Q), and fourth quartile (4Q) groups. The hearing thresholds were measured using an automatic audiometer at 0.5, 1, 2, 3, 4, and 6 kHz. Hearing loss (HL) was defined as >25 dB AHT.
Results
All the groups had 807 participants each. The area under the receiver operating characteristic curves of cadmium level for HL were 0.634 (95% confidence interval [CI], 0.621–0.646). The participants in the 4Q group had higher Low/Mid-Freq, High-Freq, and AHT values than those in the other groups in the multivariate analysis after adjusting for confounding factors. The logistic regression showed that the OR for HL per 1 µg/L increase in cadmium was 1.25 (95% CI, 1.09–1.44; p=0.002) on the multivariate analysis. Moreover, the multivariate logistic regression analyses revealed that the participants in the 4Q group exhibited a 1.59-, 1.38-, and 1.41-fold higher odds for HL than those in the 1Q, 2Q, and 3Q groups, respectively.
Conclusion
High cadmium level quartile was associated with increased hearing thresholds and HL among the Korean adult population.

Citations

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  • The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death
    Jennifer Galdieri, Chloe Adams, María Padilla, Tamara M. Stawicki
    Molecular and Cellular Neuroscience.2023; 124: 103815.     CrossRef
Case reports
Successful engraftment after infusion of multiple low doses of CD34+ cells from a poorly matched sibling donor in a patient with severe aplastic anemia
Chang Dae Kum, Mi Jin Lee, Jun Eun Park
Yeungnam Univ J Med. 2019;36(2):148-151.   Published online December 21, 2018
DOI: https://doi.org/10.12701/yujm.2019.00038
  • 4,227 View
  • 103 Download
AbstractAbstract PDF
The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that 2×106 CD34+ cells/kg is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was 15.9×108 cells/kg and 0.95×106 cells/kg, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.
Surgical treatment of esotropia and unilateral ptosis in a patient with Cornelia de Lange syndrome
Won Jae Kim
Yeungnam Univ J Med. 2019;36(2):152-154.   Published online December 17, 2018
DOI: https://doi.org/10.12701/yujm.2019.00066
  • 4,277 View
  • 85 Download
AbstractAbstract PDF
Cornelia de Lange syndrome (CdLS) is a rare multisystemic disorder that is characterized by mental retardation, prenatal and postnatal growth retardation, limb anomalies, and distinctive facial features, which include arched eyebrows that often meet in the middle (synophrys), long eyelashes, low-set ears, small and widely spaced teeth, and a small and upturned nose. Ophthalmic manifestations include long eyelashes, nasolacrimal duct obstruction, myopia, ptosis, and strabismus. There has been no report of surgical treatment for esotropia and unilateral ptosis in patients with CdLS in Korea. We report a patient with CdLS who underwent surgical treatment for esotropia and unilateral ptosis with a good surgical outcome.
Imatinib-induced hepatitis treated by corticosteroids in a patient with metastatic gastrointestinal stromal tumor
Min Kyu Kang, Heon Ju Lee, Joon Hyuk Choi
Yeungnam Univ J Med. 2019;36(2):155-158.   Published online January 21, 2019
DOI: https://doi.org/10.12701/yujm.2019.00115
  • 4,087 View
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  • 1 Citations
AbstractAbstract PDF
Imatinib mesylate is currently used as the first-line treatment for metastatic gastrointestinal stromal tumors (GISTs). Imatinib-induced hepatotoxicity in patients with GIST is very rare. Its features vary from subclinical elevation of serum aminotransferase to clinically apparent acute hepatitis, which is associated with immunologic reactions. Imatinib-induced hepatotoxicity with autoimmune-like features can be treated by the discontinuation of imatinib mesylate and the administration of oral steroids. Here, we report a case of late-onset imatinib-induced hepatitis with autoimmune-like features in a patient with metastatic GIST, which was improved by oral corticosteroids.

Citations

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  • Antioxidant-Based Preventive Effect of Phytochemicals on Anticancer Drug-Induced Hepatotoxicity
    Ji Eon Park, Chi-Hoon Ahn, Hyo-Jung Lee, Deok Yong Sim, Su Yeon Park, Bonglee Kim, Bum Sang Shim, Dae Young Lee, Sung-Hoon Kim
    Antioxidants & Redox Signaling.2023;[Epub]     CrossRef
Rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer
Eunjung Kong, Sung Ae Koh, Won Jae Kim
Yeungnam Univ J Med. 2019;36(2):159-162.   Published online February 15, 2019
DOI: https://doi.org/10.12701/yujm.2019.00129
  • 3,636 View
  • 87 Download
  • 1 Citations
AbstractAbstract PDF
The most cases with orbital metastases have been reported in patients with a prior established diagnosis of cancer and widespread systemic involvement. However, ocular symptoms can be developed as an initial presentation of cancer in patients without cancer history. We report a case of rapid progression from trochlear nerve palsy to orbital apex syndrome as an initial presentation of advanced gastric cancer.

Citations

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  • Neoplastic nerve lesions
    Deep K. Patel, Kelly G. Gwathmey
    Neurological Sciences.2022; 43(5): 3019.     CrossRef

JYMS : Journal of Yeungnam Medical Science