Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean.

Hong Soo Jung; Joo Hyun Lee; Jun Sakong; Sung Wook Bae; Jung Hye Kim; Jae Ryong Kim

doi:10.12701/yujm.2007.24.2.252

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Original Article Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean.: Hong Soo Jung, Joo Hyun Lee, Jun Sakong, Sung Wook Bae, Jung Hye Kim, Jae Ryong Kim; Journal of Yeungnam Medical Science 2007;24(2):252-261
DOI: https://doi.org/10.12701/yujm.2007.24.2.252
Published online: December 31, 2007

¹Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea. kimjr@med.yu.ac.kr
²Department of Preventive Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
³Health Promotion Center, Yeungnam University Hospital, Daegu, Korea.

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Abstract

BACKGROUND
Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. MATERIALS AND METHODS: In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. RESULTS: The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. CONCLUSION: These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.

Keywords: Obesity;Beta-3 adrenergic receptor;Uncoupling protein 2;Polymorphism;Body Mass Index

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