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Original articles
Dentistry
Galectin-3 as a possible link between periodontitis and chronic kidney disease: a cross-sectional study
Sri Vidhya Marimuthu, Devi Arul, Muthukumar Santhanakrishnan, Ramprasad Elumalai, Sandhya Suresh, Sathya Selvarajan, Ravindranath Dhulipalla, Ramanarayana Boyapati
J Yeungnam Med Sci. 2025;42:22.   Published online January 20, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.22
  • 1,096 View
  • 93 Download
AbstractAbstract PDF
Background
Chronic periodontitis is associated with various systemic inflammatory diseases; however, research on its association with chronic kidney disease (CKD) is relatively limited. Because both conditions share common risk factors, systemic inflammation plays a key role in the progression of these diseases. Galectin-3 (Gal-3) is a proinflammatory cytokine that plays an important role in chronic inflammatory diseases and is a potential biomarker. This study aimed to measure salivary Gal-3 levels in patients with periodontitis and CKD to better understand their association and evaluate Gal-3 as a diagnostic biomarker for these conditions.
Methods
Seventy-five patients were categorized into three groups: Group I, patients with CKD and periodontitis (n=25); Group II, patients with chronic periodontitis who were systemically healthy (n=25); and Group III, patients with CKD without chronic periodontitis (n=25). Demographic characteristics and periodontal and renal parameters were recorded for each patient. Saliva samples were collected to evaluate Gal-3 levels using an enzyme-linked immunosorbent assay.
Results
Patients with chronic periodontitis and CKD and those with chronic periodontitis alone (Groups I and II, respectively) showed significantly higher salivary Gal-3 levels than patients with CKD alone (Group III) (p<0.001). Bivariate correlation analysis indicated a strong relationship between clinical parameters and Gal-3 levels across all three groups.
Conclusion
Salivary Gal-3 level is a valuable early diagnostic marker of chronic periodontitis and CKD.
Cardiology and Cardiovascular Medicine
Complete or incomplete revascularization in patients with left main culprit lesion acute myocardial infarction with multivessel disease: a retrospective observational study
Sun Oh Kim, Hong-Ju Kim, Jong-Il Park, Kang-Un Choi, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Jong-Seon Park, Sung-Ho Her, Ki-Yuk Chang, Tae-Hoon Ahn, Myung-Ho Jeong, Seung-Woon Rha, Hyo-Soo Kim, Hyeon-Cheol Gwon, In-Whan Seong, Kyung-Kuk Hwang, Seung-Ho Hur, Kwang-Soo Cha, Seok-Kyu Oh, Jei-Keon Chae, Ung Kim
J Yeungnam Med Sci. 2025;42:18.   Published online December 19, 2024
DOI: https://doi.org/10.12701/jyms.2025.42.18
  • 7,183 View
  • 159 Download
AbstractAbstract PDF
Background
Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better.
Methods
We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year.
Results
After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different.
Conclusion
There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.
Review article
Medical Informatics
Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review
Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang
J Yeungnam Med Sci. 2025;42:8.   Published online November 18, 2024
DOI: https://doi.org/10.12701/jyms.2024.01004
  • 6,175 View
  • 119 Download
AbstractAbstract PDF
Digital therapeutics (DTx) are emerging as a transformative innovation in healthcare offering evidence-based digital interventions for the treatment, management, and prevention of various diseases and disorders. In Korea, DTx have gained significant attention as potential solutions to the increasing burden of chronic diseases and mental health conditions. However, the Korean DTx market faces several challenges that hinder its widespread adoption and integration into the national healthcare system. This study provides a comprehensive analysis of the current state of the DTx market in Korea, identifies the key challenges impeding its growth, and proposes strategies for overcoming these obstacles. This study utilized a literature review and market analysis approach to examine the latest research, industry reports, and regulatory documents related to DTx. The analysis focused on three primary areas: (1) the current regulatory landscape, (2) technological advancements and challenges, and (3) economic and commercial factors influencing DTx adoption in Korea. A comparative analysis of global regulatory practices was also conducted to identify best practices. The findings revealed that while Korea has made significant strides in supporting DTx development, the market remains in its early stages. The key challenges include underdeveloped regulatory frameworks, issues with data quality and security, and a lack of established reimbursement pathways. We recommend developing tailored regulatory frameworks for DTx, enhancing policy support for small and medium-sized enterprises involved in DTx development, and increasing investments in technological infrastructure. By addressing these challenges, Korea could position itself as a leader in the global DTx market, delivering innovative and effective treatments to enhance patient care and outcomes.
Original articles
Public Health, Environmental, and Occupational Health
Factors associated with musculoskeletal pain in professional dancers, including lapse period of group practice due to the COVID-19 outbreak: repeated-measures analysis
Kiook Baek, Yu-Mi Choi, Joon Sakong
J Yeungnam Med Sci. 2024;41(3):196-206.   Published online May 17, 2024
DOI: https://doi.org/10.12701/jyms.2024.00171
  • 2,660 View
  • 47 Download
AbstractAbstract PDFSupplementary Material
Background
This study investigated the prevalence and associated factors of musculoskeletal pain among professional dancers who experienced a lapse in group practice due to coronavirus disease 2019.
Methods
General characteristics, practice time, region of musculoskeletal pain due to injury using the visual numeric scale (VNS), and causative motion were surveyed among professional dancers. Pain of VNS 0 to 3 was categorized as “no or minor,” 4 to 6 was categorized as “moderate,” and 7 to 10 was categorized as “severe.” The causal motions of musculoskeletal pain were analyzed according to body region. Factors other than motion associated with pain were also analyzed.
Results
In total, 368 participants were included. In the univariate analysis, age and practice time were positively associated with “moderate” pain. Practice time, dance experience, and postural accuracy were positively associated with “severe” pain, as was performing Korean traditional dance. In the multivariable analysis, practice time, group practice, and age were positively associated with pain of VNS 4 to 10, and practice time, group practice, and Korean traditional dance were positively associated with pain of VNS 7 to 10.
Conclusion
Among the factors related to dancer training, practice time, group practice, and dance type affect the occurrence of pain.
Nephrology
Effect of pitavastatin on erythrocyte membrane fatty acid content in patients with chronic kidney disease: two-arm parallel randomized controlled trial
Minna Kim, Seong Eun Kim, Su Mi Lee, Won Suk An
J Yeungnam Med Sci. 2024;41(3):188-195.   Published online May 8, 2024
DOI: https://doi.org/10.12701/jyms.2024.00094
  • 3,086 View
  • 99 Download
AbstractAbstract PDFSupplementary Material
Background
Statins reduce the risk of cardiovascular events in patients with chronic kidney disease (CKD). Although diabetes mellitus (DM) is a reported side effect of statin treatment, some studies have indicated that pitavastatin does not cause DM. The present study investigated the effect of pitavastatin on the fatty acid (FA) content of erythrocyte membranes, which affects the occurrence of DM and cardiovascular diseases. In addition, changes in adiponectin and glycated hemoglobin (HbA1c) levels were evaluated after pitavastatin treatment.
Methods
A total of 45 patients were enrolled, 28 of whom completed the study. Over 24 weeks, 16 patients received 2 mg pitavastatin and 12 patients received 10 mg atorvastatin. Dosages were adjusted after 12 weeks if additional lipid control was required. There were 10 and nine patients with DM in the pitavastatin and atorvastatin groups, respectively. Erythrocyte membrane FAs and adiponectin levels were measured using gas chromatography and enzyme-linked immunosorbent assay, respectively.
Results
In both groups, saturated FAs, palmitic acid, trans-oleic acid, total cholesterol, and low-density lipoprotein cholesterol levels were significantly lower than those at baseline. The arachidonic acid (AA) content in the erythrocyte membrane increased significantly in the pitavastatin group, but adiponectin levels were unaffected. HbA1c levels decreased in patients treated with pitavastatin. No adverse effects were associated with statin treatment.
Conclusion
Pitavastatin treatment in patients with CKD may improve glucose metabolism by altering erythrocyte membrane AA levels. In addition, pitavastatin did not adversely affect glucose control in patients with CKD and DM.
Psychiatry and Mental Health
The characteristics of elderly suicidal attempters in the emergency department in Korea: a retrospective study
Ji-Seon Jang, Wan-Seok Seo, Bon-Hoon Koo, Hey-Geum Kim, Seok-Ho Yun, So-Hey Jo, Dae-Seok Bai, Young-Gyo Kim, Eun-Jin Cheon
J Yeungnam Med Sci. 2024;41(1):30-38.   Published online December 29, 2023
DOI: https://doi.org/10.12701/jyms.2023.01004
  • 2,561 View
  • 84 Download
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Background
Although Korea ranks first in the suicide rate of elderly individuals, there is limited research on those who attempt suicide, with preventive measures largely based on population-based studies. We compared the demographic and clinical characteristics of elderly individuals who attempted suicide with those of younger adults who visited the emergency department after suicide attempts and identified the factors associated with lethality in the former group.
Methods
Individuals who visited the emergency department after a suicide attempt from April 1, 2017, to January 31, 2020, were included. Participants were classified into two groups according to age (elderly, ≥65 years; adult, 18–64 years). Among the 779 adult patients, 123 were elderly. We conducted a chi-square test to compare the demographic and clinical features between these groups and a logistic regression analysis to identify the risk factors for lethality in the elderly group.
Results
Most elderly participants were men, with no prior psychiatric history or suicide attempts, and had a higher prevalence of underlying medical conditions and attributed their attempts to physical illnesses. Being sober and planning suicide occurred more frequently in this group. In the elderly group, factors that increased the mortality rate were biological male sex (p<0.05), being accompanied by family members (p<0.05), and poisoning as a suicide method (p<0.01).
Conclusion
Suicide attempts in elderly individuals have different characteristics from those in younger adults and are associated with physical illness. Suicides in the former group are unpredictable, deliberate, and fatal. Therefore, tailored prevention and intervention strategies addressing the characteristics of those who are elderly and attempt suicide are required.

Citations

Citations to this article as recorded by  
  • Analysis of suicide cases in post-mortem examination files of the Department of Forensic Medicine at the Medical University of Białystok in the years 2016-2021 = Analiza samobójstw w materiale sekcyjnym Zakładu Medycyny Sądowej Uniwersytetu Medycznego w B
    Anna Francuziak, Paulina Kulasza, Kinga Kozłowska, Julia Janica, Urszula Cwalina, Anna Niemcunowicz-Janica, Michał Szeremeta
    Archives of Forensic Medicine and Criminology.2024; 74(2): 106.     CrossRef
Physical therapy, Sports Therapy, and Rehabilitation
Incidence and risk factors of deep vein thrombosis and pulmonary thromboembolism after spinal cord disease at a rehabilitation unit: a retrospective study
Yoonhee Kim, Minjae Jeong, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Du Hwan Kim
J Yeungnam Med Sci. 2023;40(Suppl):S56-S64.   Published online September 20, 2023
DOI: https://doi.org/10.12701/jyms.2023.00689
  • 3,607 View
  • 90 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Background
Deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) are major complications of spinal cord disease. However, studies of their incidence in Korean patients are limited. Thus, this study investigated the incidence and risk factors of DVT and PTE in Korean patients with spinal cord disease.
Methods
We retrospectively analyzed the medical records of 271 patients with spinal cord disease who were admitted to a rehabilitation unit within 3 months of disease onset at a tertiary hospital. The presence of DVT and PTE was mainly determined using Doppler ultrasonography and chest embolism computed tomography. Risk factor analysis included variables such as sex, age, obesity, completeness of motor paralysis, neurological level of injury, cause of injury, lower extremity fracture, active cancer, and functional ambulation category (FAC) score.
Results
The incidences of DVT and PTE in the patients with spinal cord disease were both 6.3%. Risk factor analysis revealed that age of ≥65 years (p=0.031) and FAC score of ≤1 (p=0.023) were significantly associated with DVT development. Traumatic cause of injury (p=0.028) and DVT (p<0.001) were significant risk factors of PTE.
Conclusion
Patients with spinal cord disease developed DVT and PTE within 3 months of disease onset with incidence rates of 6.3% and 6.3%, respectively. Age of ≥65 years and an FAC of score ≤1 were risk factors for DVT. Traumatic cause of injury and DVT were risk factors for PTE. However, given the inconsistent results of previous studies, the risk factors for DVT and PTE remain inconclusive. Therefore, early screening for DVT and PTE should be performed in patients with acute-to-subacute spinal cord disease regardless of the presence or absence of these risk factors.

Citations

Citations to this article as recorded by  
  • Associations of RBC counts and incidence of DVT in patients with spinal cord injury: a five year observational retrospective study
    Zhang Jinlong, Wang Cheng, He Chengqi
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures
    Yong Jiao, Xiaohong Mu
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
Gastroenterology and Hepatology
Association between total body muscle percentage and prevalence of non-alcoholic fatty liver disease in Korean adults findings from an 18-year follow-up: a prospective cohort study
Byoung Chan Ahn, Chul Yong Park, Jung Hee Hong, Ki Ook Baek
J Yeungnam Med Sci. 2023;40(Suppl):S47-S55.   Published online August 29, 2023
DOI: https://doi.org/10.12701/jyms.2023.00605
  • 2,756 View
  • 63 Download
AbstractAbstract PDFSupplementary Material
Background
This study aimed to elucidate the association between total lean muscle mass and the incidence of non-alcoholic fatty liver disease (NAFLD) in the adult Korean population.
Methods
Utilizing data derived from the 18-year prospective cohort of the Korean Genome and Epidemiology Study, NAFLD was diagnosed via the hepatic steatosis index with an established cutoff value of 36. Lean muscle mass was assessed via bioelectrical impedance analysis and subsequently divided into tertiles. A generalized mixed model with a logit link was employed for repeated measures data analysis, accounting for potential confounders.
Results
Analysis encompassed 7,794 participants yielding 49,177 measurements. The findings revealed a markedly increased incidence of NAFLD in the lower tertiles of muscle mass, specifically, tertile 1 (odds ratio [OR], 20.65; 95% confidence interval [CI], 9.66–44.11) and tertile 2 (OR, 4.57; 95% CI, 2.11–9.91), in comparison to tertile 3. Age-dependent decreases in the OR were observed within the tertile 1 group, with ORs of 10.12 at age of 40 years and 4.96 at age of 80 years. Moreover, each 1%-point increment in total muscle mass corresponded with an estimated OR of 0.87 (95% CI, 0.82–0.93) for NAFLD resolution.
Conclusions
The study demonstrates a significant association between total muscle mass and NAFLD prevalence among Korean adults. Given the potential endocrine role of muscle mass in NAFLD pathogenesis, interventions aimed at enhancing muscle mass might serve as an effective public health strategy for mitigating NAFLD prevalence.
Case report
Pathology and Forensic Medicine
Classical Hodgkin lymphoma following follicular lymphoma: a case report
Bomi Kim
J Yeungnam Med Sci. 2023;40(Suppl):S113-S122.   Published online August 17, 2023
DOI: https://doi.org/10.12701/jyms.2023.00584
  • 3,534 View
  • 145 Download
AbstractAbstract PDF
The simultaneous, composite, or sequential occurrence of follicular lymphoma (FL) and classical Hodgkin lymphoma (HL), both of which originate from germinal center B-cell, is rare. Questions have been raised with regard to the type of tests that pathologists should perform when observing the presence of a “large-cell lymphoma” following an FL and what are the most critical pathological points for diagnosis. Here, we present a case of a classical HL following an FL after administering rituximab-bendamustine (R-Benda) chemotherapy. Furthermore, we also summarized the literature and compared this case with other HLs that followed FLs. A 55-year-old woman was diagnosed with a grade 3A FL of the breast and axillary lymph node masses. She completed six R-Benda chemotherapy cycles for stage IV FL. Twenty-three months after the diagnosis, follow-up image studies showed an increase in the size and number of the lesions. Biopsies of the neck lymph node and liver were performed, and the diagnosis was classical HL. Sequential or composite FL and HL may sometimes develop from the same clone because they share the same genetic alterations, such as B-cell lymphoma (Bcl)-2 or Bcl-6 translocation. When a large-cell lymphoma is found after the treatment of FL, classical HL should be considered a pathological differential diagnosis, and histological, immunohistochemical, or molecular investigations must be considered during the diagnostic process.
Original articles
Dentistry
Evaluation of periodontal status in women with polycystic ovary syndrome versus healthy women: a cross-sectional study
Sandhya Pavankumar, Pavan Kumar Yellarthi, Sandeep JN, Ramanarayana Boyapati, Trinath Kishore Damera, Naveen Vital Kumar G
J Yeungnam Med Sci. 2023;40(Suppl):S17-S22.   Published online May 8, 2023
DOI: https://doi.org/10.12701/jyms.2023.00143
  • 3,472 View
  • 137 Download
  • 4 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
Polycystic ovary syndrome (PCOS) affects approximately 4% to 12% of females of reproductive age. Previous studies have shown an association between systemic and periodontal diseases. This study aimed to compare the prevalence of periodontal disease in women with PCOS and healthy women.
Methods
A total of 196 women aged 17 to 45 years were included in this study. Oral hygiene index-simplified (OHI-S), gingival index (GI), community periodontal index (CPI), and loss of attachment (LA) were assessed. Individuals who smoked, were pregnant, had any systemic disease (such as type 1 or type 2 diabetes mellitus, cardiovascular disease, malignancy, osteoporosis, and thyroid dysfunction), had a history of systemic antibiotic use in the past three months, or received any periodontal intervention in the past 6 months of screening were excluded. Student t-test was used to analyze the data. A p-value of <0.05 was considered statistically significant.
Results
Despite similar OHI-S scores (p=0.972) in the two groups, women with PCOS had significantly higher GI, CPI, and LA scores than healthy women (p<0.001).
Conclusion
Periodontal disease was more prevalent in women with PCOS than in healthy women. This finding may be due to the synergistic effects of PCOS and periodontitis on proinflammatory cytokines. PCOS may have an effect on periodontal disease, and vice versa. Hence, education on periodontal health and early detection and intervention for periodontal diseases is of paramount importance in patients with PCOS.

Citations

Citations to this article as recorded by  
  • A Potential Link Between Oral Microbiota and Female Reproductive Health
    Justyna Marcickiewicz, Małgorzata Jamka, Jarosław Walkowiak
    Microorganisms.2025; 13(3): 619.     CrossRef
  • The Association Between Periodontal Disease and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
    Vincenzo Bitonti, Tiziana Perri, Lorenzo Cigni, Domenico Familiari, Giuseppe Vazzana, Rocco Franco
    Dentistry Journal.2025; 13(5): 188.     CrossRef
  • Insight of the interrelationship and association mechanism between periodontitis and diabetes mellitus
    Yongqiang Yang, Xia Sun, Yucheng Yang, Yingchun Qie
    Regenerative Therapy.2024; 26: 1159.     CrossRef
Nephrology
Cortical thickness of the rostral anterior cingulate gyrus is associated with frailty in patients with end-stage renal disease undergoing hemodialysis in Korea: a cross-sectional study
Sang Hyun Jung, Jong Soo Oh, So-Young Lee, Hye Yun Jeong
J Yeungnam Med Sci. 2023;40(4):381-387.   Published online March 24, 2023
DOI: https://doi.org/10.12701/jyms.2022.00941
  • 2,697 View
  • 52 Download
AbstractAbstract PDF
Background
Frailty is defined as a condition of being weak and delicate, and it represents a state of high vulnerability to adverse health outcomes. Recent studies have suggested that the cingulate gyrus is associated with frailty in the elderly population. However, few imaging studies have explored the relationship between frailty and the cingulate gyrus in patients with end-stage renal disease (ESRD) undergoing hemodialysis.
Methods
Eighteen right-handed patients with ESRD undergoing hemodialysis were enrolled in the study. We used the FreeSurfer software package to estimate the cortical thickness of the regions of interest, including the rostral anterior, caudal anterior, isthmus, and posterior cingulate gyri. The Beck Depression Inventory, Beck Anxiety Inventory, and laboratory tests were also conducted.
Results
The cortical thickness of the right rostral anterior cingulate gyrus (ACG) was significantly correlated with the Fried frailty index, age, and creatinine level. Multiple regression analysis indicated that the cortical thickness of the right rostral ACG was associated with frailty after controlling for age and creatinine level.
Conclusion
Our results indicate that the cortical thickness of the rostral ACG may be associated with frailty in patients with ESRD on hemodialysis and that the rostral ACG may play a role in the frailty mechanism of this population.
Case report
Neurology
Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report
Chae Hun Lee, Byeong Joo Choi, Jung Hun Kim, Tae Woong Yang, Gi Jeong Kim, Ha Young Shin, Se Hoon Kim, Seung Woo Kim
J Yeungnam Med Sci. 2023;40(4):430-434.   Published online February 13, 2023
DOI: https://doi.org/10.12701/jyms.2022.00850
  • 2,404 View
  • 45 Download
AbstractAbstract PDF
Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.
Original article
Cardiology and Cardiovascular Medicine
Outcomes after repair of complete atrioventricular canal with a modified single-patch technique: a retrospective study
George Samanidis, Konstantinos Kostopanagiotou, Meletios Kanakis, Georgios Kourelis, Kyriaki Kolovou, Georgios Vagenakis, Dimitrios Bobos, Nicholas Giannopoulos
J Yeungnam Med Sci. 2023;40(2):187-192.   Published online February 1, 2023
DOI: https://doi.org/10.12701/jyms.2022.00759
  • 2,667 View
  • 69 Download
AbstractAbstract PDF
Background
This study aimed to present the short- and midterm outcomes after complete atrioventricular canal defect (CAVC) repair using a single-patch technique.
Methods
This study included 30 children who underwent surgical correction of the CAVC using a single-patch technique.
Results
The median age of the patients was 5.7 months (interquartile range [IQR], 5.0–7.5 months), and 23 patients (76.7%) had type A CAVC. Fourteen patients (46.7%) were female and 17 (56.7%) had been diagnosed with Down syndrome. The in-hospital mortality rate was 0%. No deaths were observed during a median follow-up of 4 years (IQR, 3.5–5.0 years). Patients without Down syndrome were associated with late moderate mitral regurgitation (MR) (p=0.02). Late MR less than moderate degree was observed in 96.6%, 78.5%, and 50% of patients after 2, 4, and 5 years of follow-up, respectively, while late tricuspid valve regurgitation less than moderate degree was observed in 96.7%, 85.9%, and 59.0% of patients after 2, 4, and 6 years of follow-up, respectively. After a median follow-up of 4 years, only one patient had required surgical repair of a left ventricular outflow tract obstruction, which occurred 26 months after the first operation. Multivariable logistic regression analysis adjusted for the type of CAVC, sex, Down syndrome, age, and weight revealed that the absence of Down syndrome was a risk factor for late moderate MR (MR-2) (odds ratio, 0.05; 95% confidence interval, 0.006–0.50; p=0.01).
Conclusion
A single-patch technique for CAVC surgical repair is a safe method with acceptable short- and midterm results.
Review articles
Radiology, Radiotherapy & Diagnostic Imaging
Hepatic encephalopathy on magnetic resonance imaging and its uncertain differential diagnoses: a narrative review
Chun Geun Lim, Myong Hun Hahm, Hui Joong Lee
J Yeungnam Med Sci. 2023;40(2):136-145.   Published online January 10, 2023
DOI: https://doi.org/10.12701/jyms.2022.00689
  • 8,987 View
  • 345 Download
  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Hepatic encephalopathy (HE) is a severe neuropsychiatric abnormality in patients with either acute or chronic liver failure. Typical brain magnetic resonance imaging findings of HE are bilateral basal ganglia high signal intensities due to manganese deposition in chronic liver disease and hyperintensity in T2, fluid-attenuated inversion recovery, or diffusion-weighted imaging (DWI) with hemispheric white matter changes including the corticospinal tract. Low values on apparent diffusion coefficient mapping of the affected area on DWI, indicating cytotoxic edema, can be observed in acute HE. However, neuropsychological impairment in HE ranges from mild deficits in psychomotor abilities affecting quality of life to stupor or coma with higher grades of hepatic dysfunction. In particular, the long-lasting compensatory mechanisms for the altered metabolism in chronic liver disease make HE imaging results variable. Therefore, the clinical relevance of imaging findings is uncertain and differentiating HE from other metabolic diseases can be difficult. The recent introduction of concepts such as “acute-on-chronic liver failure (ACLF),” a new clinical entity, has led to a change in the clinical view of HE. Accordingly, there is a need to establish a corresponding concept in the field of neuroimaging diagnosis. Herein, we review HE from a historical and etiological perspective to increase understanding of brain imaging and help establish an imaging approach for advanced new concepts such as ACLF. The purpose of this manuscript is to provide an understanding of HE by reviewing neuroimaging findings based on pathological and clinical concepts of HE, thereby assisting in neuroimaging interpretation.

Citations

Citations to this article as recorded by  
  • Cell–cell communications in the brain of hepatic encephalopathy: The neurovascular unit
    Kyuwan Choi, Yena Cho, Yerin Chae, So Yeong Cheon
    Life Sciences.2025; 363: 123413.     CrossRef
  • A Case of Hepatic Encephalopathy With Diffuse Brainstem Signal Changes on Magnetic Resonance Imaging
    Hiromu Yurimoto, Taiki Matsubayashi, Isamu Shibata, Misako Furuki, Masato Obayashi
    Cureus.2025;[Epub]     CrossRef
  • Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy
    Chun Geun Lim, Hui Joong Lee
    Journal of the Korean Society of Radiology.2024; 85(2): 381.     CrossRef
  • Response to “Brain Lesions in Liver Cirrhosis May Not Only Be Due to Hepatic Encephalopathy”
    Hui Joong Lee
    Journal of the Korean Society of Radiology.2024; 85(4): 827.     CrossRef
  • Altered Mental Status in the Solid-Organ Transplant Recipient
    Nicolas Weiss, Henning Pflugrad, Prem Kandiah
    Seminars in Neurology.2024; 44(06): 670.     CrossRef
  • Reversibility of structural and functional alterations of hepatic encephalopathy
    Henning Pflugrad, Ann-Katrin Hennemann
    Metabolic Brain Disease.2024;[Epub]     CrossRef
  • Rule out all differential causes before attributing cerebral bleeding to 5-aminolevulinic acid
    Josef Finsterer, Sounira Mehri
    Child's Nervous System.2023; 39(4): 847.     CrossRef
  • Minimal hepatic encephalopathy: clinical, neurophysiological, neuroimaging markers
    P. I. Kuznetsova, A. A. Raskurazhev, S. N. Morozova, I. M. Lovchev, M. S. Novruzbekov, M. M. Tanashyan
    Russian neurological journal.2023; 28(5): 21.     CrossRef
  • Prevalence of Precipitating Factors of Hepatic Encephalopathy at Nangarhar Regional Hospital
    Ameerullah Razai, Ismail Khan Safi, Said Abdul Jamil Saidi, Said Inam Saidi
    Nangarhar University International Journal of Biosciences.2023; : 34.     CrossRef
Endocrinology, Diabetes, and Metabolism
Long-term management of Graves disease: a narrative review
Hyo-Jeong Kim
J Yeungnam Med Sci. 2023;40(1):12-22.   Published online November 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00444
  • 18,949 View
  • 581 Download
  • 5 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Graves disease (GD) is the most common cause of hyperthyroidism, accounting for more than 90% of cases in Korea. Patients with GD are treated with any of the following: antithyroid drugs (ATDs), radioactive iodine (RAI) therapy, or thyroidectomy. Most patients begin treatment with ATDs, and clinical guidelines suggest that the appropriate treatment period is 12 to 18 months. While RAI treatment and surgery manage thyrotoxicosis by destroying or removing thyroid tissue, ATDs control thyrotoxicosis by inhibiting thyroid hormone synthesis and preserving the thyroid gland. Although ATDs efficiently control thyrotoxicosis symptoms, they do not correct the main etiology of GD; therefore, frequent relapses can follow. Recently, a large amount of data has been collected on long-term ATDs for GD, and low-dose methimazole (MMZ) is expected to be a good option for remission. For the long-term management of recurrent GD, it is important to induce remission by evaluating the patient’s drug response, stopping ATDs at an appropriate time, and actively switching to surgery or RAI therapy, if indicated. Continuing drug treatment for an extended time is now encouraged in patients with a high possibility of remission with low-dose MMZ. It is also important to pay attention to the quality of life of the patients. This review aimed to summarize the appropriate treatment methods and timing of treatment transition in patients who relapsed several times while receiving treatment for GD.

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  • A 30-year-old male patient who experienced recurring weakness in bilateral upper and lower extremities: a clinical vignette
    Soo Hyun Ahn, Mathieu Boudier-Revéret, Seoyon Yang, Min Cheol Chang
    Journal of Yeungnam Medical Science.2025; 42: 27.     CrossRef
  • Outcomes of Fixed-Dose Radioactive Iodine Therapy in Hyperthyroidism and Optimization of Follow-Up After Treatment Failure With Low-Dose Antithyroid Medication
    Panita Kantikool, Naphat Buraphanawibun
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  • Hub genes and key pathways of Graves’ disease: bioinformatics analysis and validation
    Duan-rong Zhuang, Xin Hu, Hui-bin Huang
    Hormones.2025;[Epub]     CrossRef
  • Commentary: Azathioprine as an adjuvant therapy in severe Graves’ disease: a randomized controlled open-label clinical trial
    Madhukar Mittal, Azher Rizvi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Total Thyroidectomy – A Cost-effective Alternative to Anti-Thyroid Drugs in the Management of Grave's Disease
    Erivelto Volpi, Leonardo M. Volpi
    Clinical Thyroidology.2023; 35(5): 183.     CrossRef
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    Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
    Diagnostics.2023; 13(16): 2707.     CrossRef
  • Mechanisms and Treatment Options for Hyperthyroid-Induced Osteoporosis: A Narrative Review
    Robert M Branstetter, Rahib K Islam, Collin A Toups, Amanda N Parra, Zachary Lee, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D Kaye
    Cureus.2023;[Epub]     CrossRef
Focused Review article
Neurology
Pain in amyotrophic lateral sclerosis: a narrative review
Soyoung Kwak
J Yeungnam Med Sci. 2022;39(3):181-189.   Published online June 8, 2022
DOI: https://doi.org/10.12701/jyms.2022.00332
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AbstractAbstract PDF
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

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  • Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers
    James Chmiel, Marta Stępień-Słodkowska
    Journal of Clinical Medicine.2025; 14(2): 545.     CrossRef
  • Progressive Bulbar Palsy (PBP) or Bulbar Onset MND: “A Case Report”
    Sagar S. Bhovare, Akhataribano S. Sayyad
    Journal of Pharmacy and Bioallied Sciences.2025; 17(Suppl 1): S971.     CrossRef
  • Health-related quality of life across disease stages in patients with amyotrophic lateral sclerosis: results from a real-world survey
    Katie Stenson, T. E. Fecteau, L. O’Callaghan, P. Bryden, J. Mellor, J. Wright, L. Earl, O. Thomas, H. Iqbal, S. Barlow, S. Parvanta
    Journal of Neurology.2024; 271(5): 2390.     CrossRef
  • Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
    Vincenzo Pota, Pasquale Sansone, Sara De Sarno, Caterina Aurilio, Francesco Coppolino, Manlio Barbarisi, Francesco Barbato, Marco Fiore, Gianluigi Cosenza, Maria Beatrice Passavanti, Maria Caterina Pace, Enzo Emanuele
    Behavioural Neurology.2024;[Epub]     CrossRef
  • Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions
    Bogdan Bjelica, Maj-Britt Bartels, Jasper Hesebeck-Brinckmann, Susanne Petri
    Journal of Neurology.2024; 271(7): 3953.     CrossRef
  • Perceived Pain in People Living with Amyotrophic Lateral Sclerosis—A Scoping Review
    Debora Rosa, Laura Ingrande, Ilaria Marcomini, Andrea Poliani, Giulia Villa, Martina Sodano, Duilio Fiorenzo Manara
    Nursing Reports.2024; 14(4): 3023.     CrossRef
  • Pain in Amyotrophic Lateral Sclerosis Is Underrated
    Soyoung Kwak, Min Cheol Chang
    International journal of Pain.2024; 15(2): 51.     CrossRef
  • Likely Pathogenic Variants of Cav1.3 and Nav1.1 Encoding Genes in Amyotrophic Lateral Sclerosis Could Elucidate the Dysregulated Pain Pathways
    Zsófia Flóra Nagy, Balázs Sonkodi, Margit Pál, Péter Klivényi, Márta Széll
    Biomedicines.2023; 11(3): 933.     CrossRef
  • Palliative Care in Amyotrophic Lateral Sclerosis
    Sebastiano Mercadante, Lou'i Al-Husinat
    Journal of Pain and Symptom Management.2023; 66(4): e485.     CrossRef
  • The blind spot and challenges in pain management
    Min Cheol Chang
    Journal of Yeungnam Medical Science.2022; 39(3): 179.     CrossRef
  • Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?
    Bradley Roberts, Frances Theunissen, Francis L. Mastaglia, P. Anthony Akkari, Loren L. Flynn
    International Journal of Molecular Sciences.2022; 23(16): 9364.     CrossRef
  • Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report
    Siyang Peng, Weiqian Chang, Yukun Tian, Yajing Yang, Shaohong Li, Jinxia Ni, Wenzeng Zhu
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Case reports
Emergency and Critical Care Medicine
Prolonged oral sildenafil use-induced Mondor disease: a case report
Han Sol Chung, You Ho Mun
J Yeungnam Med Sci. 2022;39(3):262-265.   Published online May 24, 2022
DOI: https://doi.org/10.12701/jyms.2022.00220
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AbstractAbstract PDF
Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related to prolonged oral sildenafil use. A 46-year-old man visited our emergency department with sustained penile pain and swelling that began 7 hours after sexual intercourse. He had used oral sildenafil intermittently for 11 years and engaged in sexual intercourse the previous night after taking sildenafil. Examination revealed no evidence of intercourse-related trauma to the genital area or an increase in penile skin temperature. However, penile swelling and tenderness over the protruding dorsal penile vein were noted. A color Doppler ultrasound examination was performed immediately, which showed hyperechoic thrombosis in the right superficial dorsal penile vein that was dilated, with soft tissue swelling and no detectable flow signal in the thrombotic lesion. The patient was diagnosed as having penile MD. The patient was treated conservatively. Some reports have indicated the involvement of sildenafil in thrombogenesis. Physicians should be aware that prolonged oral sildenafil use may be associated with penile MD.

Citations

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  • Penile superficial dorsal vein thrombophlebitis following prolonged sexual activity
    Ahmed Adam Osman, Hanan HassanHirei, Abdulkadir Isse Mohamed, Shuayb Moallim Ali, Amal Naleye Ali, Abdikarim Hussein Mohamed
    Radiology Case Reports.2024; 19(12): 6161.     CrossRef
  • A case with Penile Mondor’s disease
    Hülya Cenk, Gülbahar Saraç, İrem Mantar Yanatma
    TURKDERM.2023; : 151.     CrossRef
Obstetrics, Gynecology, and Reproductive Medicine
Laparoscopic excision and repair of a cesarean scar pregnancy in a woman with uterine didelphys: a case report
Seong-Eon Park, Ji-Eun Ryu, Tae-Kyu Jang
J Yeungnam Med Sci. 2023;40(2):202-206.   Published online May 16, 2022
DOI: https://doi.org/10.12701/jyms.2022.00115
  • 3,634 View
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  • 2 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Cesarean scar pregnancy (CSP) is a rare complication that occurs in less than 1% of ectopic pregnancies, and uterine didelphys is one of the rarest uterine forms. We report a successful laparoscopic excision and repair of CSP in a woman with uterine didelphys and a double vagina. A 34-year-old gravida one, para one woman with a history of low transverse cesarean section presented to our hospital with a suspected CSP. She was confirmed to have uterine didelphys with a double vagina during an infertility examination 7 years earlier. Magnetic resonance imaging showed a 2.5-cm gestational sac-like cystic lesion in the lower segment of the right uterus at the cesarean scar. We decided to perform a laparoscopic approach after informing the patient of the surgical procedure. The lower segment of the previous cesarean site was excised with monopolar diathermy to minimize bleeding. We identified the gestational sac in the lower segment of the right uterus, which was evacuated using spoon forceps. The myometrium and serosa of the uterus were sutured layer-by-layer using synthetic absorbable sutures. No remnant gestational tissue was visible on follow-up ultrasonography one month after the surgery. This laparoscopic approach to CSP in a woman with uterine didelphys is an effective and safe method of treatment. In women with uterine anomalies, it is important to confirm the exact location of the gestational sac by preoperative imaging for successful surgery.

Citations

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  • Clinical study of two reversible arterial blockade methods in the treatment of scar pregnancy under combined hysterolaparoscopy
    Wei Wei
    American Journal of Translational Research.2024; 16(11): 6770.     CrossRef
Original articles
Dentistry
Effect of nonsurgical periodontal therapy and smoking status on hematological variables related to anemia of chronic disease in chronic periodontitis patient: a case-control study
Sangita Show, Somen Bagchi, Arka Kanti Dey, Ramanarayana Boyapati, Pritish Chandra Pal, Kanikanti Siva Tejaswi
J Yeungnam Med Sci. 2022;39(3):244-249.   Published online May 16, 2022
DOI: https://doi.org/10.12701/jyms.2022.00045
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AbstractAbstract PDF
Background
Chronic infectious, inflammatory, or neoplastic disorders are associated with anemia of chronic disease. Chronic inflammatory diseases such as periodontitis may contribute to masked anemia, especially in smokers. This study was aimed at verifying and comparing the efficacy of nonsurgical periodontal therapy (NSPT) for improving anemia among chronic periodontitis patients with and without the habit of smoking.
Methods
Thirty systemically healthy individuals with chronic periodontitis were divided into two groups of 15 each, smokers (group A) and nonsmokers (group B). The groups were compared based on hematological parameters such as serum erythropoietin (SE) and serum ferritin (SF) levels at baseline and 3 months after NSPT for anemia evaluation.
Results
The baseline SE levels in groups A and B were 11.84 and 15.19 mIU/mL (p=0.031), respectively; the corresponding levels at 3 months after NSPT were 13.00 and 17.74 mIU/mL (p=0.022). The baseline SF levels in groups A and B were 95.49 and 44.86 ng/mL (p=0.018), respectively; the corresponding levels at 3 months after NSPT were 77.06 and 39.05 ng/mL (p=0.009). Group B showed a significant increase and decrease in the SE and SF levels, respectively, at 3 months after NSPT (p=0.035 and p=0.039, respectively), whereas group A showed insignificant changes (p=0.253 and p=0.618, respectively).
Conclusion
NSPT led to an improvement in anemia among chronic periodontitis patients. However, the improvement is less in smokers compared to that in nonsmokers. Furthermore, SF and SE levels might serve as effective biomarkers for assessing anemia in smokers and nonsmokers with chronic periodontitis.
Gastroenterology and Hepatology
Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study
Joo Kyung Kim, Jae Hee Cheon
J Yeungnam Med Sci. 2023;40(1):37-48.   Published online April 18, 2022
DOI: https://doi.org/10.12701/jyms.2022.00031
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AbstractAbstract PDF
Background
Commensal bacteria play an important role in the pathogenesis of inflammatory bowel disease (IBD) and probiotics have been used as treatment options. We aimed to explore the current use of probiotics and factors associated with their prescription in patients with IBD.
Methods
This cross-sectional study was conducted on a single hospital-based cohort. Patients were eligible if they were ≥18 years old, visited the IBD clinic as an outpatient more than twice during the study period, and had a confirmed diagnosis of IBD. Patients were divided into two groups based on the prescription of probiotics. Clinical assessments were compared between the two groups.
Results
In total, 217 patients were enrolled in this study. In patients with Crohn disease (CD), moderate or severe abdominal pain; prior use of methotrexate (MTX), iron, thiopurines, or biologics; history of IBD-related surgery; and stool frequency were independently associated with the prescription of probiotics. In patients with ulcerative colitis (UC), moderate or severe abdominal pain, hematochezia, stool frequency, and moderate or severe physician global assessment score were independently associated with the prescription of probiotics.
Conclusion
Increased disease activity may be associated with fewer prescriptions of probiotics in patients with IBD. However, physicians prescribed probiotics to control symptoms, such as abdominal pain and increased stool frequency in patients with UC and CD, and hematochezia in patients with UC. Additionally, the use of MTX and iron, and a history of IBD-related surgeries were associated with more frequent probiotic prescriptions in patients with CD.

Citations

Citations to this article as recorded by  
  • The role of the fecal microbiota in inflammatory bowel disease
    Rami Khalaf, Martina Sciberras, Pierre Ellul
    European Journal of Gastroenterology & Hepatology.2024; 36(11): 1249.     CrossRef
  • Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022
    Cuilan Huang, Wujuan Hao, Xuyang Wang, Renmin Zhou, Qiong Lin
    Frontiers in Microbiology.2023;[Epub]     CrossRef
Review article
Anatomy
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review
Haneol Ko, Sang-Pil Yoon
J Yeungnam Med Sci. 2022;39(4):269-277.   Published online February 14, 2022
DOI: https://doi.org/10.12701/jyms.2021.01683
  • 9,923 View
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AbstractAbstract PDF
The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

Citations

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  • Application of Optogenetic Neuromodulation in Regulating Depression
    Jin Zhang, Xiang Peng, Man Li, Xiao-ming Zhang, Hong-chun Xiang
    Current Medical Science.2025; 45(2): 185.     CrossRef
  • Modulating Proteasome Function with Polyphenol Metabolites: A Promising Therapeutic Avenue for Alzheimer's Disease
    Nyerovwo Charity Okei
    European Journal of Medical and Health Research.2024; 2(2): 16.     CrossRef
  • A comprehensive review of optical fiber technologies in optogenetics and their prospective developments in future clinical therapies
    Siyu Chen, Zhuo Wang, Kun Xiao, Benzhao He, Jing Zhao, Xin Yang, Qingqing Liu, Anuj K. Sharma, Arnaldo Leal Junior, Rui Min
    Optics & Laser Technology.2024; 179: 111332.     CrossRef
  • Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders
    Salman Alfihed, Majed Majrashi, Muhammad Ansary, Naif Alshamrani, Shahad H. Albrahim, Abdulrahman Alsolami, Hala A. Alamari, Adnan Zaman, Dhaifallah Almutairi, Abdulaziz Kurdi, Mai M. Alzaydi, Thamer Tabbakh, Faisal Al-Otaibi
    Biosensors.2024; 14(7): 335.     CrossRef
  • Daily Dynamics of Resting-State Electroencephalographic Theta and Gamma Fluctuations Are Associated With Cognitive Performance in Healthy Aging
    Kenza Bennis, Francis Eustache, Fabienne Collette, Gilles Vandewalle, Thomas Hinault, Gali Weissberger
    The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.2024;[Epub]     CrossRef
  • Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
    Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
    Scientific Reports.2023;[Epub]     CrossRef
  • Light-Controlled Modulation and Analysis of Neuronal Functions
    Carlo Matera, Piotr Bregestovski
    International Journal of Molecular Sciences.2022; 23(21): 12921.     CrossRef
Original articles
Pediatrics, Perinatology, and Child Health
Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study
Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon
J Yeungnam Med Sci. 2022;39(1):46-52.   Published online August 26, 2021
DOI: https://doi.org/10.12701/yujm.2021.01221
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  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.

Citations

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  • Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
    Pattharaporn Sinthuprasith, Karn Wejaphikul, Dolrutai Puttawong, Hataitip Tang-Ngam, Naphatsorn Sanrattana, Kevalee Unachak, Prapai Dejkhamron
    Journal of Pediatric Endocrinology and Metabolism.2024; 37(6): 487.     CrossRef
  • COVID-19 infection and inactivated vaccination: Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes
    Zhen-Ran Xu, Li Xi, Jing Wu, Jin-Wen Ni, Fei-Hong Luo, Miao-Ying Zhang
    World Journal of Diabetes.2024; 15(12): 2276.     CrossRef
  • Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
    Anas Elgenidy, Ahmed K. Awad, Khaled Saad, Mostafa Atef, Hatem Helmy El-Leithy, Ahmed A. Obiedallah, Emad M. Hammad, Faisal-Alkhateeb Ahmad, Ahmad M. Ali, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher Fathy Taha
    Pediatric Research.2023; 93(5): 1149.     CrossRef
  • Comments on Rahmati et al., The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis. J Med Virol. 2022; 1‐16 (doi: 10.1002/jmv.27996)
    Joachim Rosenbauer, Anna Stahl‐Pehe, Sabrina Schlesinger, Oliver Kuß
    Journal of Medical Virology.2023;[Epub]     CrossRef
  • Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes
    Clemens Kamrath, Alexander J. Eckert, Reinhard W. Holl, Joachim Rosenbauer, Andrea Scaramuzza
    Pediatric Diabetes.2023; 2023: 1.     CrossRef
  • Difficulties in differential diagnosis of carbohydrate metabolism disorders in patients with coronavirus infection in real clinical practice. Case report
    Tatyana N. Markova, Mukhamed S. Stas, Valentina V. Chibisova, Anastasia A. Anchutina
    Consilium Medicum.2023; 25(4): 241.     CrossRef
  • Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review
    Valeria Calcaterra, Veronica Maria Tagi, Raffaella De Santis, Andrea Biuso, Silvia Taranto, Enza D’Auria, Gianvincenzo Zuccotti
    Journal of Clinical Medicine.2023; 12(16): 5248.     CrossRef
  • Glycemic control and complications of type 2 diabetes mellitus in children and adolescents during the COVID-19 outbreak
    Kyeong Eun Oh, Yu Jin Kim, Ye Rim Oh, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(4): 275.     CrossRef
  • Incidence of Diabetic Ketoacidosis Among Pediatrics With Type 1 Diabetes Prior to and During COVID-19 Pandemic: A Meta-Analysis of Observational Studies
    Osamah M. Alfayez, Kholood S. Aldmasi, Nada H. Alruwais, Nouf M. Bin Awad, Majed S. Al Yami, Omar A. Almohammed, Abdulaali R. Almutairi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Comparison of Initial Presentation of Pediatric Diabetes Before and During the Coronavirus Disease 2019 Pandemic Era
    Yoonha Lee, Minseung Kim, Kyeongeun Oh, Eungu Kang, Young-Jun Rhie, Jieun Lee, Yong Hee Hong, Young-Lim Shin, Jae Hyun Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
    Masoud Rahmati, Maryam Keshvari, Shahrzad Mirnasuri, Dong K. Yon, Seung W. Lee, Jae Il Shin, Lee Smith
    Journal of Medical Virology.2022; 94(11): 5112.     CrossRef
  • COVID-19 and diabetes: What do we know so far?
    Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian
    Experimental Biology and Medicine.2022; 247(15): 1330.     CrossRef
  • Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
    Ioanna Farakla, Theano Lagousi, Michael Miligkos, Nicolas C. Nicolaides, Ioannis-Anargyros Vasilakis, Maria Mpinou, Maria Dolianiti, Elina Katechaki, Anilia Taliou, Vasiliki Spoulou, Christina Kanaka-Gantenbein
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
Treatment decision for cancer patients with fever during the COVID-19 pandemic
Treatment decision for cancer patients with fever during the coronavirus disease 2019 (COVID-19) pandemic
In Hee Lee, Sung Ae Koh, Soo Jung Lee, Sun Ah Lee, Yoon Young Cho, Ji Yeon Lee, Jin Young Kim
Yeungnam Univ J Med. 2021;38(4):344-349.   Published online August 23, 2021
DOI: https://doi.org/10.12701/yujm.2021.01144
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AbstractAbstract PDF
Background
Cancer patients have been disproportionally affected by the coronavirus disease 2019 (COVID-19) pandemic, with high rates of severe outcomes and mortality. Fever is the most common symptom in COVID-19 patients. During the COVID-19 pandemic, physicians may have difficulty in determining the cause of fever (COVID-19, another infection, or cancer fever) in cancer patients. Furthermore, there are no specific guidelines for managing cancer patients with fever during the COVID-19 pandemic. Thus, this study evaluated the clinical characteristics and outcomes of cancer patients with fever during the COVID-19 pandemic.
Methods
This study retrospectively reviewed the medical records of 328 cancer patients with COVID-19 symptoms (fever) admitted to five hospitals in Daegu, Korea from January to October 2020. We obtained data on demographics, clinical manifestations, laboratory test results, chest computed tomography images, cancer history, cancer treatment, and outcomes of all enrolled patients from electronic medical records.
Results
The most common COVID-19-like symptoms were fever (n=256, 78%). Among 256 patients with fever, only three (1.2%) were diagnosed with COVID-19. Most patients (253, 98.8%) with fever were not diagnosed with COVID-19. The most common solid malignancies were lung cancer (65, 19.8%) and hepatobiliary cancer (61, 18.6%). Twenty patients with fever experienced a delay in receiving cancer treatment. Eighteen patients discontinued active cancer treatment because of fever. Major events during the treatment delay period included death (2.7%), cancer progression (1.5%), and major organ dysfunction (2.7%).
Conclusion
Considering that only 0.9% of patients tested for COVID-19 were positive, screening for COVID-19 in cancer patients with fever should be based on the physician’s clinical decision, and patients might not be routinely tested.
Case reports
Immunology and Allergy
Idiopathic multicentric Castleman disease presenting progressive reticular honeycomb infiltration of lung and immunoglobulin G and immunoglobulin G4 dominant hypergammaglobulinemia: a case report
Hyun-Je Kim, Young-Hoon Hong
J Yeungnam Med Sci. 2022;39(2):153-160.   Published online July 5, 2021
DOI: https://doi.org/10.12701/yujm.2021.01039
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AbstractAbstract PDF
Multicentric Castleman disease (MCD) is an uncommon systemic lymphoproliferative disorder that may cause multiple organ damage. Castleman disease-associated diffuse parenchymal lung disease (DPLD) has not been well studied. A 32-year-old man was referred to our hospital for progressive generalized weakness, light-headedness, and dyspnea on exertion for more than one year. Laboratory evaluations showed profound anemia, an elevated erythrocyte sedimentation rate, and an increased C-reactive protein level with polyclonal hypergammaglobulinemia. Chest radiography, computed tomography (CT), and positron emission tomography-CT scan demonstrated diffuse lung infiltration with multiple cystic lesions and multiple lymphadenopathy. In addition to these clinical laboratory findings, bone marrow, lung, and lymph node biopsies confirmed the diagnosis of idiopathic MCD (iMCD). Siltuximab, an interleukin-6 inhibitor, and glucocorticoid therapy were initiated. The patient has been tolerating the treatment well and had no disease progression or any complications in 4 years. Herein, we report this case of human herpesvirus-8-negative iMCD-associated DPLD accompanied by multiple cystic lesions, multiple lymphadenopathy, and polyclonal hypergammaglobulinemia with elevated immunoglobulin G (IgG) and IgG4 levels. We recommend a close evaluation of MCD in cases of DPLD with hypergammaglobulinemia.
Pediatrics, Perinatology, and Child Health
Successful treatment with vedolizumab in an adolescent with Crohn disease who had developed active pulmonary tuberculosis while receiving infliximab
Sujin Choi, Bong Seok Choi, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2021;38(3):251-257.   Published online February 19, 2021
DOI: https://doi.org/10.12701/yujm.2020.00878
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  • 142 Download
  • 2 Crossref
AbstractAbstract PDF
Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

Citations

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  • The safety of vedolizumab in a patient with Crohn’s disease who developed anti-TNF-alpha agent associated latent tuberculosis infection reactivation: A case report
    Yuya Sugiyama, Nobuhiro Ueno, Shion Tachibana, Yu Kobayashi, Yuki Murakami, Takahiro Sasaki, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
    Medicine.2023; 102(28): e34331.     CrossRef
  • Vedolizumab Is Safe and Efficacious for the Treatment of Pediatric-Onset Inflammatory Bowel Disease Patients Who Fail a Primary Biologic Agent
    Sujin Choi, Eun Sil Kim, Yiyoung Kwon, Mi Jin Kim, Yon Ho Choe, Byung-Ho Choe, Ben Kang
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
Original article
Hematology
A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults
Abraham Kwak, Nani Jung, Ye Jee Shim, Heung Sik Kim, Hyun Ji Lim, Jae Min Lee, Mi Hwa Heo, Young Rok Do
Yeungnam Univ J Med. 2021;38(3):208-218.   Published online November 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00591
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  • 8 Crossref
AbstractAbstract PDF
Background
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.
Methods
The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated.
Results
Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1–83 years), and the median follow-up duration was 8.5 months (range, 0–204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×109/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH.
Conclusion
Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

Citations

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  • Prevalence and mortality of haemophagocytic lymphohistiocytosis in dengue fever: a systematic review and meta-analysis
    Leong Tung Ong, Roovam Balasubramaniam
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2024; 118(11): 711.     CrossRef
  • Predicting relapsed/refractory disease in childhood hemophagocytic lymphohistiocytosis based on clinical features at diagnosis: A 13-year single-institute retrospective study in Thailand
    Pattranan Kusontammarat, Chane Choed-Amphai, Lalita Sathitsamitphong, Watchareewan Sontichai, Rungrote Natesirinilkul, Pimlak Charoenkwan
    Annals of Hematology.2024; 103(10): 3963.     CrossRef
  • Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report
    Li Huang, Jie Tan, Peihao Lin, Zixuan Chen, Qihua Huang, Haiyan Yao, Lihong Jiang, Baoyi Long, Youming Long
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Hemophagocytic Lymphohistiocytosis Triggered by Herpes Simplex Virus 1 and 2: A Narrative Review
    Andria Papazachariou, Petros Ioannou
    Hematology Reports.2024; 16(3): 487.     CrossRef
  • Spontaneous Resolution of Hemophagocytic Lymphohistiocytosis in a Child Infected with Epstein–Barr Virus
    Rita Alfattal, Hussain Sadeq, Abdullah Ali
    Journal of Applied Hematology.2023; 14(1): 57.     CrossRef
  • Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
    María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado
    Journal of Leukocyte Biology.2022; 112(4): 607.     CrossRef
  • Secondary Hemophagocytic Lymphohistiocytosis and Autoimmune Cytopenias: Case Description and Review of the Literature
    Bruno Fattizzo, Marta Ferraresi, Juri Giannotta, Wilma Barcellini
    Journal of Clinical Medicine.2021; 10(4): 870.     CrossRef
  • HLH-Like Syndrome and Rhabdomyolysis in an Adolescent Patient
    Lauren T. Maloney, Bronwyn Baz, Dia Hazra
    Pediatrics.2021;[Epub]     CrossRef
Case report
Hematology
Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease
Sang Min Lee, Young Tae Lim, Kyung Mi Jang, Mi Jin Gu, Jong Ho Lee, Jae Min Lee
Yeungnam Univ J Med. 2021;38(3):245-250.   Published online November 11, 2020
DOI: https://doi.org/10.12701/yujm.2020.00654
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AbstractAbstract PDF
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome—HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m2/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.

Citations

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  • Histiocytic necrotizing lymphadenitis with hemophagocytic lymphohistiocytosis in adults: A single‐center analysis of 5 cases
    Qingqing Chen, Jing Zhang, Huijun Huang, Tonglu Qiu, Ze Jin, Yu Shi, Huayuan Zhu, Lei Fan, Jianyong Li, Wenyu Shi, Yi Miao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • A young Saudi female with combined hemophagocytic lympho-histiocytosis and Kikuchi’s disease: A case report
    Kamal Al-Zahrani, Batol Gasmelseed, Hesham Waaer Shadi, Rehab Y AL-Ansari
    SAGE Open Medical Case Reports.2023;[Epub]     CrossRef
  • Cefalea y fiebre: no todo es lo que parece
    María Pilar Iranzo-Alcolea, Carmen Ariño-Palao, Grisell Starita-Fajardo, Andrés González-García, Cecilia Suárez-Carantoña
    Revista Española de Casos Clínicos en Medicina Interna.2023; 8(2): 105.     CrossRef
  • Kikuchi–Fujimoto disease: literature review and report of four cases
    V. G. Potapenko, V. V. Baykov, А. Yu. Markova, N. B. Mikhailova, A. S. Ter‑Grigoryan, Yu. А. Krivolapov
    Oncohematology.2022; 17(4): 48.     CrossRef
Focused Review article
Pulmonary and Respiratory Medicine
An update on the role of bronchoscopy in the diagnosis of pulmonary disease
June Hong Ahn
Yeungnam Univ J Med. 2020;37(4):253-261.   Published online August 28, 2020
DOI: https://doi.org/10.12701/yujm.2020.00584
  • 11,882 View
  • 266 Download
  • 13 Crossref
AbstractAbstract PDF
Bronchoscopy has evolved over the past few decades and has been used by respiratory physicians to diagnose various airway and lung diseases. With the popularization of medical check-ups and growing interest in health, early diagnosis of lung diseases is essential. With the development of endobronchial ultrasound, ultrathin bronchoscopy, and electromagnetic navigational bronchoscopy, bronchoscopy has been able to widen its scope in diagnosing pulmonary diseases. In this review, we have described the brief history, role, and complications of bronchoscopy used in diagnosing pulmonary lesions, from simple flexible bronchoscopy to bronchoscopy combined with several up-to-date technologies.

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    Yi Huang, Kaishan Jiang, Xiaochen Wang, Siyu Zou, Ziyong Sun, Shiji Wu, Bin Wang, Hongyan Hou, Feng Wang
    Computers in Biology and Medicine.2025; 190: 110111.     CrossRef
  • Endobronchial hamartomas as a rare cause of chronic cough
    Selsabil Daboussi, Asma Saidane, Abdellatif Syrine, Samira Mhamdi, Faten Gargouri, Houssem Messaoudi, Saber Hachicha, Chiraz Aichaouia, Zied Moatemri
    Respiratory Medicine Case Reports.2025; 55: 102210.     CrossRef
  • Application value of fibro-bronchoscopic cryosurgery combined with medication in the treatment of tracheobronchial tuberculosis
    Yue-Ying Zhou, Hui-Juan Li, Kai-Jia Wu, Ji-Chan Shi, Xian-Gao Jiang, Gui-Qing He, Ning Pan, Chao-Chao Qiu, Hong-Ye Ning, Zheng-Xing Wu
    BMC Surgery.2025;[Epub]     CrossRef
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    Tomohiro Akaba, Taisuke Jo, Jun Suzuki, Yuya Kimura, Hiroki Matsui, Kiyohide Fushimi, Etsuko Tagaya, Hideo Yasunaga
    Annals of the American Thoracic Society.2025; 22(5): 707.     CrossRef
  • Disposable Versus Reusable Bronchoscopes: A Narrative Review of Cost-effectiveness, Risk of Cross-contamination and Environmental Impact
    Illaa Smesseim, Johannes M.A. Daniels, Jouke Annema, Peter I. Bonta, Dirk-Jan Slebos
    Archivos de Bronconeumología.2024; 60(4): 250.     CrossRef
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    Andreea Ionela Dumachi, Cătălin Buiu
    Electronics.2024; 13(23): 4697.     CrossRef
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    Mohammad M. Seyedshahabedin, Timothy P. Howarth, Lin Mo, Edwina Biancardi, Subash S. Heraganahally
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  • Endobronchial ultrasound‐guided re‐biopsy of non–small cell lung cancer with acquired resistance after EGFR tyrosine kinase inhibitor treatment
    Kyung Soo Hong, Jinmo Cho, Jong Geol Jang, Min Hye Jang, June Hong Ahn
    Thoracic Cancer.2023; 14(4): 363.     CrossRef
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    Fateh Kashkash, Abdullah Khorri
    Annals of Medicine & Surgery.2023; 85(2): 146.     CrossRef
  • Invasive Diagnostic Procedures from Bronchoscopy to Surgical Biopsy—Optimization of Non-Small Cell Lung Cancer Samples for Molecular Testing
    Nensi Lalić, Aleksandra Lovrenski, Miroslav Ilić, Olivera Ivanov, Marko Bojović, Ivica Lalić, Spasoje Popević, Mihailo Stjepanović, Nataša Janjić
    Medicina.2023; 59(10): 1723.     CrossRef
  • Utility of Radial Probe Endobronchial Ultrasound Guided Transbronchial Lung Biopsy in Bronchus Sign Negative Peripheral Pulmonary Lesions
    Kyung Soo Hong, Kwan Ho Lee, Jin Hong Chung, Kyeong-Cheol Shin, Hyun Jung Jin, Jong Geol Jang, June Hong Ahn
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Radial Probe Endobronchial Ultrasound Using Guide Sheath-Guided Transbronchial Lung Biopsy in Peripheral Pulmonary Lesions without Fluoroscopy
    Kyung Soo Hong, Heeyun Ahn, Kwan Ho Lee, Jin Hong Chung, Kyeong-Cheol Shin, Hyun Jung Jin, Jong Geol Jang, Seok Soo Lee, Min Hye Jang, June Hong Ahn
    Tuberculosis and Respiratory Diseases.2021; 84(4): 282.     CrossRef
  • Advances in the science and treatment of respiratory diseases
    Jin Hong Chung
    Yeungnam University Journal of Medicine.2020; 37(4): 251.     CrossRef
Case reports
Gastroenterology and Hepatology
Co-existence of relapsing polychondritis and Crohn disease treated successfully with infliximab
Hye-In Jung, Hyun Jung Kim, Ji-Min Kim, Ju Yup Lee, Kyung Sik Park, Kwang Bum Cho, Yoo Jin Lee
Yeungnam Univ J Med. 2021;38(1):70-73.   Published online June 19, 2020
DOI: https://doi.org/10.12701/yujm.2020.00304
  • 6,587 View
  • 101 Download
  • 2 Crossref
AbstractAbstract PDF
Relapsing polychondritis (RP) is a rare, progressive immune-mediated systemic inflammatory disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with other autoimmune diseases. However, the co-occurrence of RP and Crohn disease (CD) has rarely been reported. Herein, we present a 35-year-old woman diagnosed with RP and CD, who was refractory to initial conventional medications, including azathioprine and glucocorticoid, but who subsequently responded to infliximab (IFX). For both diseases, remission was sustained with IFX. There has been no previous report regarding the successful treatment of co-existing RP and CD with IFX.

Citations

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  • Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review
    Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hay
    Internal Medicine.2025;[Epub]     CrossRef
  • Relapsing Polychondritis in a Patient With Auricular Chondritis and Inflammatory Bowel Disease: A Case Report With Literature Review
    David D Bickford, Thomas Ritter, Pinky Jha, Hari R Paudel
    Cureus.2022;[Epub]     CrossRef
Nephrology
Development of donepezil-induced hypokalemia following treatment of cognitive impairment
Dongryul Kim, Hye Eun Yoon, Hoon Suk Park, Seok Joon Shin, Bum Soon Choi, Byung Soo Kim, Tae Hyun Ban
Yeungnam Univ J Med. 2021;38(1):65-69.   Published online June 1, 2020
DOI: https://doi.org/10.12701/yujm.2020.00269
  • 7,066 View
  • 138 Download
  • 1 Crossref
AbstractAbstract PDF
Donepezil is a cholinesterase inhibitor used extensively to treat Alzheimer disease. The increased cholinergic activity is associated with adverse effects, therefore gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are common. Hypokalemia is a rare adverse event that occurs in less than 1% of donepezil-treated patients. Although hypokalemia of mild and moderate grade does not present serious signs and symptoms, severe hypokalemia often results in prolonged hospitalization and mortality. Herein, we report a case of hypokalemia developed after the initiation of donepezil therapy for cognitive impairment.

Citations

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  • Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
    Luminita Capatina, Elena Todirascu-Ciornea, Edoardo Marco Napoli, Giuseppe Ruberto, Lucian Hritcu, Gabriela Dumitru
    Antioxidants.2020; 9(11): 1083.     CrossRef
Pediatrics, Perinatology, and Child Health
Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in NUDT15 R139C
Jaewoan Bae, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2020;37(4):332-336.   Published online May 22, 2020
DOI: https://doi.org/10.12701/yujm.2020.00178
  • 6,542 View
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  • 3 Crossref
AbstractAbstract PDF
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients who are NUDT15 poor metabolizers and consider the use of an alternative immunomodulatory therapy. We report a case of a 12-year-old Korean girl with Crohn’s disease (CD), in whom thiopurine-induced leukopenia was prevented by initiation of azathioprine (AZA) therapy at a low dose (0.5 mg/kg/day) and early detection of significant hair loss and white blood cell (WBC) count decrease at 17 days from the start of AZA treatment. The WBC count dropped from 8,970/μL to 3,370/μL in 2 weeks, and AZA treatment was stopped because of concerns of potential leukopenia in the near future. Her WBC count recovered to 5,120/μL after 3 weeks. Gene analysis later revealed that she had a homozygous mutation in NUDT15 R139C, resulting in a poor metabolizing activity of NUDT15. In situations when NUDT15 genotyping is unavailable, initiation of AZA therapy at 0.5 mg/kg/day with close observation of hair loss and WBC counts within 2 weeks may be an alternative way to prevent thiopurine-induced early leukopenia in Asian children with CD.

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  • Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation
    Xinmiao He, Ming Tian, Wentao Wang, Yanzhong Feng, Zhongqiu Li, Jiahui Wang, Yan Song, Jinfeng Zhang, Di Liu
    Veterinary Sciences.2023; 10(5): 307.     CrossRef
  • Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review
    Juan Gu, Yupei Lin, Yuhe Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
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    Clinical and Molecular Hepatology.2023; 29(3): 542.     CrossRef
Review article
Gastroenterology and Hepatology
Gallbladder polyps: evolving approach to the diagnosis and management
Kook Hyun Kim
Yeungnam Univ J Med. 2021;38(1):1-9.   Published online May 15, 2020
DOI: https://doi.org/10.12701/yujm.2020.00213
  • 29,519 View
  • 556 Download
  • 10 Crossref
AbstractAbstract PDF
Gallbladder (GB) polyp is a mucosal projection into the GB lumen. With increasing health awareness, GB polyps are frequently found using ultrasonography during health screening. The prevalence of GB polyps ranges between 1.3% and 9.5%. Most patients are asymptomatic and have benign characteristics. Of the nonneoplastic polyps, cholesterol polyps are most common, accounting for 60%–70% of lesions. However, a few polyps have malignant potential. Currently, the guidelines recommend laparoscopic cholecystectomy for polyps larger than 1 cm in diameter due to their malignan potential. The treatment algorithm can be influenced by the size, shape, and numbers of polyps, old age (>50 years), the presence of primary sclerosing cholangitis, and gallstones. This review summarizes the commonly recognized concepts on GB polyps from diagnosis to an algorithm of treatment.

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    Ik Hyun Jo, Chang Nyol Paik, Hong Geun Ahn, Dong Do You, Jae Hyun Han, Hyun A Kim
    The Korean Journal of Gastroenterology.2025; 85(1): 52.     CrossRef
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    Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li
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    Tian Yang, Ming-Da Wang, Gui-Lin Xie, Xiong-Hua Wang, Liu Zheng, Li-Min Wang, Guang-Fa Xiao, Yong-Qing Yang, Chao Li, Alfred Wei Chieh Kow, Feng Shen
    iLIVER.2024; 3(4): 100127.     CrossRef
  • Endoscopic ultrasound-guided gallbladder endoscopic mucosal resection: a pilot porcine study
    Huifang Pang, Quan Man, Li Min, Zheng Zhang, Shengtao Zhu, Shuyue Yang, Yao Xu, Haijun Hou, Shutian Zhang, Peng Li
    Minimally Invasive Therapy & Allied Technologies.2023; 32(1): 24.     CrossRef
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    Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G. Shelat
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    Rachel Runde, Edward D. Auyang, Raye Ng, Kaysey Llorente, Hina Arif Tiwari, Shana Elman, William M. Thompson
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  • Gallbladder polyps: diagnosis and treatment tactics (literature review)
    S. N. Perekhodov, D. V. Nikolaev, S. S. Saidov
    Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2021; 11(4): 88.     CrossRef
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    Wenqing Bao, Anan Xu, Shubin Ni, Bo Wang, Humaira Urmi, Bin Zhao, Yongmei You, Hai Hu
    Scandinavian Journal of Gastroenterology.2021; 56(12): 1450.     CrossRef
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    J.-P. Tasu, B. Bergougnoux, E. Frouin, S. Velasco, C. Aubé, N. Beydoun
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Original articles
Obstetrics, Gynecology, and Reproductive Medicine
Clinical outcomes of hysterectomy for benign diseases in the female genital tract: 6 years’ experience in a single institute
Hyo-Shin Kim, Yu-Jin Koo, Dae-Hyung Lee
Yeungnam Univ J Med. 2020;37(4):308-313.   Published online April 24, 2020
DOI: https://doi.org/10.12701/yujm.2020.00185
  • 7,057 View
  • 192 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Hysterectomy is one of the major gynecologic surgeries. Historically, several surgical procedures have been used for hysterectomy. The present study aims to evaluate the surgical trends and clinical outcomes of hysterectomy performed for benign diseases at the Yeungnam University Hospital.
Methods
We retrospectively reviewed patients who underwent a hysterectomy for benign diseases from 2013 to 2018. Data included the patients’ demographic characteristics, surgical indications, hysterectomy procedures, postoperative pathologies, and perioperative outcomes.
Results
A total of 809 patients were included. The three major indications for hysterectomy were uterine leiomyoma, pelvic organ prolapse, and adenomyosis. The most common procedure was total laparoscopic hysterectomy (TLH, 45.2%), followed by open hysterectomy (32.6%). During the study period, the rate of open hysterectomy was nearly constant (29.4%–38.1%). The mean operative time was the shortest in the single-port laparoscopic assisted vaginal hysterectomy (LAVH, 89.5 minutes), followed by vaginal hysterectomy (VH, 96.8 minutes) and TLH (105 minutes). The mean decrease in postoperative hemoglobin level was minimum in single-port LAVH (1.8 g/dL) and VH (1.8 g/dL). Conversion to open surgery or multi-port surgery occurred in five cases (0.6%). Surgical complications including wound dehiscence, organ injuries, and conditions requiring reoperation were observed in 52 cases (6.4%).
Conclusion
Minimally invasive approach was used for most hysterectomies for benign diseases, but the rate of open hysterectomy has mostly remained constant. Single-port LAVH and VH showed the most tolerable outcomes in terms of operative time and postoperative drop in hemoglobin level in selected cases.

Citations

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  • Analysis of Different Routes of Hysterectomy Based on a Prospective Algorithm and Their Complications in a Tertiary Care Institute
    Subrat Panda, Ananya Das, Rituparna Das, Nalini Sharma, Wansalan Shullai, Vinayak Jante, Anusuya Sharma, Kaushiki Singh, Prateeti Baruah, Ruksana Makakmayum, Imtiaz Wani
    Minimally Invasive Surgery.2022; 2022: 1.     CrossRef
Pulmonary and Respiratory Medicine
Polyunsaturated fatty acids, lung function, and health-related quality of life in patients with chronic obstructive pulmonary disease
Hyunji Choi, Taeyun Kim
Yeungnam Univ J Med. 2020;37(3):194-201.   Published online April 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00052
  • 6,052 View
  • 114 Download
  • 4 Crossref
AbstractAbstract PDF
Background
Dietary polyunsaturated fatty acids (PUFA) are thought to modify systemic inflammation. The present study aimed to evaluate the relationship between PUFA intake, lung function, and health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD).
Methods
In this study, we used the dataset of 6th Korea National Health and Nutrition Examination Survey, in which, a total of 22,948 individuals including 573 participants with a high probability of developing COPD were enrolled. Participants with missing data for the investigated variables were excluded. Linear regression analyses were used to evaluate the association between PUFA intake (omega-3 [N3], omega-6 [N6], and total) with lung function, and HRQoL. HRQoL was determined according to the European Quality of Life-5 Dimensions (EQ-5D). Subgroup analysis of older patients was performed. Age, sex, body mass index, smoking, alcohol, education, residence, total calorie intake, and predicted FEV1% were adjusted in all analyses.
Results
Although lung function was not associated with PUFA intake, EQ-5D index was remarkably associated with N3, N6, and total PUFA intake in a dose-dependent manner. This association was more pronounced in elderly COPD patients. Mean levels of N3, N6, and total PUFA intake were significantly higher in patients having better HRQoL with respect to mobility, self-care, and usual activities.
Conclusion
Our results suggest that N3, N6, and total PUFA intake are associated with HRQoL in COPD patients. This association may be attributed to mobility, self-care, and usual activities. Further longitudinal study is required to clarify this relationship.

Citations

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  • Association between polyunsaturated fatty acids dietary intake and pulmonary function among American children: NHANES 2007–2012
    Mengmeng Ding, Shuyan Qie, Hanming Wang
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Dietary modulation of lung lipids influences inflammatory responses to inhaled ozone
    Russell Hunter, Brenna Baird, Milad Mazloumi-Bakhshayesh, Siem Goitom, Selita Lucas, Guy Herbert, David Scieszka, Edward Davis, Haiwei Gu, Yan Jin, Barry E. Bleske, Matthew J. Campen
    Journal of Lipid Research.2024; 65(9): 100630.     CrossRef
  • Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review
    Lieke E J van Iersel, Rosanne J H C G Beijers, Harry R Gosker, Annemie M W J Schols
    Nutrition Reviews.2022; 80(6): 1434.     CrossRef
  • Medium and long chain free fatty acid receptors in the pathophysiology of respiratory diseases
    O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, M. V. Antonyuk, T. A. Gvozdenko
    Bulletin Physiology and Pathology of Respiration.2021; (80): 115.     CrossRef
Case report
Gastroenterology and Hepatology
Anti-nuclear antibody-negative immunoglobulin G4-associated autoimmune hepatitis mimicking lymphoproliferative disorders
Min Kyu Kang, Jung Gil Park, Joon Hyuk Choi
Yeungnam Univ J Med. 2020;37(2):136-140.   Published online March 24, 2020
DOI: https://doi.org/10.12701/yujm.2020.00066
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AbstractAbstract PDF
Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) is a very rare subtype of autoimmune hepatitis and characterized by marked elevated serum IgG and hepatic infiltration of IgG4-expressing plasma cells. Pathologic confirmation of hepatic IgG4-expressing plasma cells is usually required for the final diagnosis of IgG4-associated AIH. Herein, we report the case of a 47-year-old female diagnosed with autoantibody-negative IgG4-associated AIH mimicking lymphoproliferative disorders.

Citations

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  • Immunoglobulin G4-related Autoimmune Hepatitis Following Type 1 Autoimmune Pancreatitis: A Case Report and Literature Review
    Chiharu Toh, Shinichi Morita, Nobutaka Takeda, Fusako Yamazaki, Kunihiko Yokoyama, Masatoshi Sato, Daisuke Kumaki, Takeshi Sakai, Kazuhiro Funakoshi, Koichi Tsuneyama
    Internal Medicine.2025; 64(11): 1659.     CrossRef
  • A clinicopathological study of IgG4-related autoimmune hepatitis and IgG4-hepatopathy
    Atsushi Tanaka, Kenji Notohara, Maki Tobari, Masanori Abe, Takeji Umemura, Atsushi Takahashi, Akemi Tsutsui, Takanori Ito, Kohichi Tsuneyama, Atsushi Masamune, Ken-ichi Harada, Hiromasa Ohira, Mitsuhiro Kawano
    Journal of Gastroenterology.2025; 60(5): 632.     CrossRef
  • Hepatic Involvement of Diffuse Large B-Cell Lymphoma Mimicking Antinuclear Antibody-Negative Autoimmune Hepatitis Diagnosed by Liver Biopsy
    Euna Lee, Min-Kyu Kang, Gabin Moon, Mi-Jin Gu
    Medicina.2022; 59(1): 77.     CrossRef
  • Immunoglobulin G4 (IgG4)‐related autoimmune hepatitis and IgG4‐hepatopathy: A histopathological and clinical perspective
    Atsushi Tanaka, Kenji Notohara
    Hepatology Research.2021; 51(8): 850.     CrossRef
Review article
Public Health, Environmental, and Occupational Health
Reproductive toxic agents in work environments and related cases in Korea
Chulyong Park
Yeungnam Univ J Med. 2020;37(1):22-31.   Published online January 9, 2020
DOI: https://doi.org/10.12701/yujm.2019.00416
  • 10,411 View
  • 101 Download
  • 1 Crossref
AbstractAbstract PDF
There has been a growing concern and subsequent interest surrounding numerous reproductive toxic agents found in various working and non-working environments. Meanwhile, there have been many efforts in medical fields such as toxicology and epidemiology applying experimental studies to elucidate reproductive toxic agents’ characterization and health effects. However, there remains insufficient research data and inadequate evidence in humans. Adverse reproductive outcomes vary from transient, moderate health effects to severely detrimental consequences, such as permanent infertility or childhood cancer of one’s offspring. Furthermore, upon exposure to toxic agents, the latent period before reproductive health effects are observed is relatively short compared to other occupational diseases (e.g., occupational cancer); instant action is required once exposure to reproductive toxic agents is detected. Therefore, it is very important for workers and healthcare professionals to know about the reproductive toxic agents they are likely to be exposed to. In this review, we discuss the general epidemiology of reproductive health in Korea, and the information regarding these reproductive toxic agents.

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  • Association between Occupational Chemical Exposure and Sperm Parameters; A Narrative Review
    Soheila Pourmasumi, Reza Vazirinejad, Zahra Ahmadi, Ali Mehdipour, Alireza Nazari
    Journal of Occupational Health and Epidemiology.2023; 12(1): 50.     CrossRef
Original article
Gastroenterology and Hepatology
Comparison of small bowel findings using capsule endoscopy between Crohn’s disease and intestinal tuberculosis in Korea
Yong Gil Kim, Kyung-Jo Kim, Young-Ki Min
Yeungnam Univ J Med. 2020;37(2):98-105.   Published online November 22, 2019
DOI: https://doi.org/10.12701/yujm.2019.00374
  • 8,072 View
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  • 4 Crossref
AbstractAbstract PDF
Background
Little is known about capsule endoscopy (CE) findings in patients with intestinal tuberculosis who exhibit small bowel lesions. The aim of the present study was to distinguish between Crohn’s disease (CD) and intestinal tuberculosis based on CE findings.
Methods
Findings from 55 patients, who underwent CE using PillCam SB CE (Given Imaging, Yoqneam, Israel) between February 2003 and June 2015, were retrospectively analyzed.
Results
CE revealed small bowel lesions in 35 of the 55 patients: 19 with CD and 16 with intestinal tuberculosis. The median age at diagnosis for patients with CD was 26 years and 36 years for those with intestinal tuberculosis. On CE, three parameters, ≥10 ulcers, >3 involved segments and aphthous ulcers, were more common in patients with CD than in those intestinal tuberculosis. Cobblestoning was observed in five patients with CD and in none with intestinal tuberculosis. The authors hypothesized that a diagnosis of small bowel CD could be made when the number of parameters in CD patients was higher than that for intestinal tuberculosis. The authors calculated that the diagnosis of either CD or intestinal tuberculosis would have been made in 34 of the 35 patients (97%).
Conclusion
The number of ulcers and involved segments, and the presence of aphthous ulcers, were significantly higher and more common, respectively, in patients with CD than in those with intestinal tuberculosis. Cobblestoning in the small bowel may highly favor a diagnosis of CD on CE.

Citations

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  • Deep Learning Radiomics Analysis of CT Imaging for Differentiating Between Crohn’s Disease and Intestinal Tuberculosis
    Ming Cheng, Hanyue Zhang, Wenpeng Huang, Fei Li, Jianbo Gao
    Journal of Imaging Informatics in Medicine.2024; 37(4): 1516.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Difficulties in the differential diagnosis of intestinal tuberculosis and Crohn‘s disease
    M. N. Reshetnikov, D. V. Plotkin, Yu. R. Zyuzya, A. A. Volkov, O. N. Zuban, E. M. Bogorodskaya
    Acta Biomedica Scientifica.2021; 6(5): 196.     CrossRef
  • Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis
    Vishal Sharma
    Expert Review of Gastroenterology & Hepatology.2020; 14(8): 647.     CrossRef
Case report
Radiology, Radiotherapy & Diagnostic Imaging
Massive cerebral venous sinus thrombosis secondary to Graves' disease
Hye-Min Son
Yeungnam Univ J Med. 2019;36(3):273-280.   Published online September 18, 2019
DOI: https://doi.org/10.12701/yujm.2019.00339
  • 7,220 View
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  • 10 Crossref
AbstractAbstract PDF
Cerebral venous sinus thrombosis (CVT) is a rare cerebrovascular condition accounting for 0.5–1% of all types of strokes in the general population. Hyperthyroidism is associated with procoagulant and antifibrinolytic activity, thereby precipitating a hypercoagulable state that predisposes to CVT. We report the case of a 31-year-old Korean man with massive CVT and diagnosis of concomitant Graves’ disease at admission. Early diagnosis and prompt treatment of CVT are important to improve prognosis; therefore, CVT should be considered in the differential diagnosis in all patients with hyperthyroidism presenting with neurological symptoms.

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  • Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study
    Lifeng Zhang, Kaibei Li, Qifan Yang, Yao Lin, Caijuan Geng, Wei Huang, Wei Zeng
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    Margherita Paccagnella, Anna Pizzo, Veronica Calabrò, Valerio Velardi, Bruno Fabris, Stella Bernardi
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    Takumi Tashiro, Yuichi Kira, Norihisa Maeda
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    Tiziana Ciarambino, Pietro Crispino, Giovanni Minervini, Mauro Giordano
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    Pin-Yi Wu, Ruchika Meel
    Annals of Internal Medicine: Clinical Cases.2023;[Epub]     CrossRef
  • Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update
    Emanuela Maria Raho, Annibale Antonioni, Niccolò Cotta Ramusino, Dina Jubea, Daniela Gragnaniello, Paola Franceschetti, Francesco Penitenti, Andrea Daniele, Maria Chiara Zatelli, Maurizio Naccarato, Ilaria Traluci, Maura Pugliatti, Marina Padroni
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  • Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report
    Roshan Bisural, Deepak Acharya, Samaj Adhikari, Baikuntha Chaulagai, Arjun Mainali, Tutul Chowdhury, Nicole Gousy
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    Shurong Gong, Wenyao Hong, Jiafang Wu, Jinqing Xu, Jianxiang Zhao, Xiaoguang Zhang, Yuqing Liu, Rong-Guo Yu
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    Garik Yeganyan, Hasmik Sargsyan, Mariam Manukyan, Henrik Schytz, Samson Khachatryan
    Armenian Journal of Health & Medical Sciences.2022; : 52.     CrossRef
  • Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report
    Ahmed Elkhalifa Elawad Elhassan, Mohammed Omer Khalil Ali, Amina Bougaila, Mohammed Abdelhady, Hassan Abuzaid
    Journal of Investigative Medicine High Impact Case Reports.2020;[Epub]     CrossRef
Review articles
Psychiatry and Mental Health
Cognitive dysfunctions in individuals with diabetes mellitus
Hye-Geum Kim
Yeungnam Univ J Med. 2019;36(3):183-191.   Published online July 24, 2019
DOI: https://doi.org/10.12701/yujm.2019.00255
  • 17,821 View
  • 497 Download
  • 51 Crossref
AbstractAbstract PDF
Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated with a decrease in the speed of information processing, psychomotor efficiency, attention, mental flexibility, and visual perception. Longitudinal epidemiological studies of type 1 DM have indicated that chronic hyperglycemia and microvascular disease, rather than repeated severe hypoglycemia, are associated with the pathogenesis of DM-related cognitive dysfunction. However, severe hypoglycemic episodes may contribute to cognitive dysfunction in high-risk patients with DM. Type 2 DM has been associated with memory deficits, decreased psychomotor speed, and reduced frontal lobe/executive function. In type 2 DM, chronic hyperglycemia, long duration of DM, presence of vascular risk factors (e.g., hypertension and obesity), and microvascular and macrovascular complications are associated with the increased risk of developing cognitive dysfunction. The pathophysiology of cognitive dysfunction in individuals with DM include the following: (1) role of hyperglycemia, (2) role of vascular disease, (3) role of hypoglycemia, and (4) role of insulin resistance and amyloid. Recently, some investigators have proposed that type 3 DM is correlated to sporadic Alzheimer’s disease. The molecular and biochemical consequences of insulin and insulin-like growth factor resistance in the brain compromise neuronal survival, energy production, gene expression, plasticity, and white matter integrity. If patients claim that their performance is worsening or if they ask about the effects of DM on functioning, screening and assessment are recommended.

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    Selene Cansino, Frine Torres-Trejo, Cinthya Estrada-Manilla, Eira Castellanos-Domínguez, Ana Zamora-Olivares, Silvia Ruiz Velasco, Jim Grange
    Cogent Psychology.2021;[Epub]     CrossRef
  • Ингибиторы натрий-глюкозного котранспортера способны положительно влиять на состояние головного мозга
    Олег Леонидович Колесников , Алла Алексеевна Колесникова , Юлия Олеговна Тарабрина
    Естественные и Технические Науки.2021; (№11): 149.     CrossRef
  • Melatonin: new insights on its therapeutic properties in diabetic complications
    Mohammad Hossein Pourhanifeh, Azam Hosseinzadeh, Ehsan Dehdashtian, Karim Hemati, Saeed Mehrzadi
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Diabetic encephalopathy causes the imbalance of neural activities between hippocampal glutamatergic neurons and GABAergic neurons in mice
    Chun Wang, Juan Li, Shidi Zhao, Li Huang
    Brain Research.2020; 1742: 146863.     CrossRef
  • Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
    Gabriela Dumitrita Stanciu, Veronica Bild, Daniela Carmen Ababei, Razvan Nicolae Rusu, Alina Cobzaru, Luminita Paduraru, Delia Bulea
    Journal of Clinical Medicine.2020; 9(6): 1713.     CrossRef
Pathology and Forensic Medicine
Pathological interpretation of connective tissue disease-associated lung diseases
Kun Young Kwon
Yeungnam Univ J Med. 2019;36(1):8-15.   Published online January 15, 2019
DOI: https://doi.org/10.12701/yujm.2019.00101
  • 10,618 View
  • 198 Download
  • 2 Crossref
AbstractAbstract PDF
Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations. Histopathological findings of diverse morphological changes can be present in CTD-LDs airway lesions (chronic bronchitis/bronchiolitis, follicular bronchiolitis, etc.), interstitial lung diseases (nonspecific interstitial pneumonia/fibrosis, usual interstitial pneumonia, lymphocytic interstitial pneumonia, diffuse alveolar damage, and organizing pneumonia), pleural changes (acute fibrinous or chronic fibrous pleuritis), and vascular changes (vasculitis, capillaritis, pulmonary hemorrhage, etc.). CTD patients can be exposed to various infectious diseases when taking immunosuppressive drugs. Histopathological patterns of CTD-LDs are generally nonspecific, and other diseases that can cause similar lesions in the lungs must be considered before the diagnosis of CTD-LDs. A multidisciplinary team involving pathologists, clinicians, and radiologists can adequately make a proper diagnosis of CTD-LDs.

Citations

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  • Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role
    Stefano Lucà, Francesca Pagliuca, Fabio Perrotta, Andrea Ronchi, Domenica Francesca Mariniello, Giovanni Natale, Andrea Bianco, Alfonso Fiorelli, Marina Accardo, Renato Franco
    International Journal of Molecular Sciences.2024; 25(7): 3618.     CrossRef
  • Acute fibrinous and organizing pneumonia: two case reports and literature review
    Haihong Chen, Yukun Kuang, Xinyan Huang, Ziyin Ye, Yangli Liu, Canmao Xie, Ke-Jing Tang
    Diagnostic Pathology.2021;[Epub]     CrossRef
Case Report
Ophthalmology
Ocular manifestations in a patient with de novo Fabry disease
You Hyun Lee, Kyu Young Shim, Sung Bae Park, Yu Cheol Kim
Yeungnam Univ J Med. 2018;35(2):232-235.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.232
  • 6,105 View
  • 87 Download
  • 1 Crossref
AbstractAbstract PDF
Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

Citations

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  • Implications of Corneal Refractive Surgery in Patients with Fabry Disease
    Majid Moshirfar, Nour Bundogji, Alyson N. Tukan, Yasmyne C. Ronquillo
    Ophthalmology and Therapy.2022; 11(3): 925.     CrossRef
Review article
Public Health, Environmental, and Occupational Health
Implementation of a care coordination system for chronic diseases
Jung Jeung Lee, Sang Geun Bae
Yeungnam Univ J Med. 2019;36(1):1-7.   Published online December 20, 2018
DOI: https://doi.org/10.12701/yujm.2019.00073
  • 9,491 View
  • 189 Download
  • 6 Crossref
AbstractAbstract PDF
The number of people with chronic diseases has been increasing steadily but the indicators for the management of chronic diseases have not improved significantly. To improve the existing chronic disease management system, a new policy will be introduced, which includes the establishment of care plans for hypertension and diabetes patients by primary care physicians and the provision of care coordination services based on these plans. Care coordination refers to a series of activities to assist patients and their families and it has been known to be effective in reducing medical costs and avoiding the unnecessary use of the hospital system by individuals. To offer well-coordinated and high-quality care services, it is necessary to develop a service quality assurance plan, track and manage patients, provide patient support, agree on patient referral and transition, and develop an effective information system. Local governance should be established for chronic disease management, and long-term plans and continuous quality improvement are necessary.

Citations

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  • Coordination of care in health systems for users with diabetes and hypertension: a scoping review
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Coordenação do cuidado nos sistemas de saúde a usuários com diabetes e hipertensão: uma revisão de escopo
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Coordinación del cuidado en los sistemas de salud para usuarios con diabetes e hipertensión: una revisión de alcance
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Personalized, interdisciplinary patient pathway for cross-sector care of multimorbid patients (eliPfad trial): study protocol for a randomized controlled trial
    Christoph Heinrich Lindemann, Volker Burst, Linus Alexander Völker, Sebastian Brähler, Dusan Simic, Ingrid Becker, Martin Hellmich, Clarissa Kurscheid, Nadine Scholten, Ruben Krauspe, Kerstin Leibel, Stephanie Stock, Paul Thomas Brinkkoetter
    Trials.2024;[Epub]     CrossRef
  • Evaluation of the Implementation of Integrated Primary Care for Patients with Type 2 Diabetes and Hypertension in Belgium, Cambodia, and Slovenia
    Nataša Stojnić, Monika Martens, Edwin Wouters, Savina Chham, Josefien van Olmen, Katrien Danhieux, Nina Ružić Gorenjec, Ir Por, Antonija Poplas-Susič, Zalika Klemenc-Ketiš
    International Journal of Integrated Care.2024;[Epub]     CrossRef
  • Trends in the Quality of Primary Care and Acute Care in Korea From 2008 to 2020: A Cross-sectional Study
    Yeong Geun Gwon, Seung Jin Han, Kyoung Hoon Kim
    Journal of Preventive Medicine and Public Health.2023; 56(3): 248.     CrossRef
Case Reports
Pathology and Forensic Medicine
Mammary Paget’s disease without underlying malignancy of the breast
Nuri Jang, Suhwan Kang, Young Kyung Bae
Yeungnam Univ J Med. 2018;35(1):99-103.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.99
  • 7,019 View
  • 51 Download
  • 4 Crossref
AbstractAbstract PDF
Mammary Paget’s disease (MPD) is usually accompanied by underlying breast malignancy; however, a few cases have been reported as only skin lesions without any evidence of malignancy of the breast on imaging tests and microscopic examination of surgical specimen. Here, we describe a 47-year-old woman who visited our hospital who had an eczematous lesion on right nipple and areola for over 10 years. The lesion was diagnosed as Paget’s disease by punch biopsy; however, imaging studies demonstrated no breast malignancy or lymph node metastasis. The patient underwent surgery of on the nipple and areola including underlying breast tissue. No underlying malignancy was found upon microscopic examination, except for Paget’s disease. Immunohistochemical stains revealed that the tumor cells were positive for cytokeratin 7, and negativity for p63, cytokeratin 5/6, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. We report a case of MPD without underlying malignancy. To the best of our knowledge, this is the third case reported in Korea.

Citations

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  • ‘Eczematous’ dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease
    Hatice B. Zengin, Puay Hoon Tan, Regina Liu, Bruce R. Smoller
    Pathology.2024; 56(3): 300.     CrossRef
  • An unusual case of longstanding mammary Paget disease presenting with reticulated skin changes
    S. K. Dhariwal, E. Rytina, J. C. Sterling
    Clinical and Experimental Dermatology.2021; 46(4): 748.     CrossRef
  • Histopathological patterns of skin adnexal tumours in Ibadan, South-West Nigeria
    OmoladeO Adegoke, MustaphaAkanji Ajani
    Hamdan Medical Journal.2021; 14(4): 168.     CrossRef
  • Clinicopathological characteristics of mammary Paget’s disease: A single‐center 25‐year experience in Korea
    Young J. Kim, Keon H. Lee, Woo J. Lee, Chong H. Won, Sung E. Chang, Jee H. Choi, Mi W. Lee
    The Breast Journal.2020; 26(4): 806.     CrossRef
Emergency and Critical Care Medicine
Ultrasonographic findings in Fitz-Hugh-Curtis syndrome: a thickened or three-layer hepatic capsule
You Ho Moon, Jung ho Kim, Won joon Jeong, Sin-Youl Park
Yeungnam Univ J Med. 2018;35(1):127-129.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.127
  • 7,002 View
  • 68 Download
  • 1 Crossref
AbstractAbstract PDF
Fitz-Hugh-Curtis syndrome (FHCS) is characterized by inflammation of the perihepatic capsules associated with the pelvic inflammatory disease (PID). FHCS is not a serious disease, but if not treated properly, it can result in increased medical costs, prolonged treatment, and dissatisfaction with treatment. However, early recognition of FHCS in the emergency department can be difficult because its symptoms or physical findings may mimic many other diseases. Although contrast-enhanced computed tomography (CECT) is the useful imaging modality for recognition of FHCS, it is available only when a high suspicion is established. We performed point-of-care ultrasonography in an 18-year-old woman who had a sharp right upper quadrant (RUQ) abdominal pain without PID symptoms and found a thickened or three-layer hepatic capsule. These findings coincided with areas showing increased hepatic capsular enhancement in the arterial phase of CECT. These results show that if the thickened or three-layer hepatic capsule without evidence of a common cause of RUQ pain is observed on ultrasonography in women of childbearing age with RUQ abdominal pain, the physician can consider the possibility of FHCS.

Citations

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  • Analysis of Misdiagnosis of FHCS Syndrome as Cholecystitis and Literature Review
    旭旗 申
    Advances in Clinical Medicine.2022; 12(06): 5608.     CrossRef
Review Article
Nuclear Medicine
Beta-amyloid imaging in dementia
Kyung Ah Chun
Yeungnam Univ J Med. 2018;35(1):1-6.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.1
  • 9,218 View
  • 134 Download
  • 13 Crossref
AbstractAbstract PDF
Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the Aβ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as 11C-labeled Pittsburgh Compound B or 18F-labeled tracers, such as 18F-florbetaben, 18F-florbetapir, and 18F-flutemetamol, which bind to Aβ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of Aβ throughout the brain in living subjects. Aβ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.

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  • The role of neuroimaging in Alzheimer’s disease: implications for the diagnosis, monitoring disease progression, and treatment
    Julius Mulumba, Rui Duan, Bo Luo, Jiang Wu, Muhammad Sulaiman, Feng Wang, Yong Yang
    Exploration of Neuroscience.2025;[Epub]     CrossRef
  • Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
    Shadaan Ahmad, Lubna Ahmad, Mohammad Adil, Ritu Sharma, Saara khan, Nazeer Hasan, Mohd. Aqil
    Drug Delivery and Translational Research.2025;[Epub]     CrossRef
  • Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
    Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
    Neurobiology of Aging.2024; 133: 67.     CrossRef
  • Current status of PET tracers for the early diagnosis of Alzheimer's disease
    Yuying Li, Tianqing Liu, Qi Zeng, Mengchao Cui
    TrAC Trends in Analytical Chemistry.2024; 172: 117546.     CrossRef
  • Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits
    Saurabh Kumar Jha, Vinod Kumar Nelson, Punna Rao Suryadevara, Siva Prasad Panda, Chitikela P. Pullaiah, Mohana Vamsi Nuli, Mehnaz Kamal, Mohd Imran, Saijyothi Ausali, Mosleh Mohammad Abomughaid, Rashi Srivastava, Rahul Deka, Pingal Pritam, Neha Gupta, Har
    Ageing Research Reviews.2024; 100: 102386.     CrossRef
  • A Study on the Inhibition of AChE Activity by Ethanolic Extract of Tibet Wild Gymnadenia crassinervis and Its Protective and Reparative Effects on Aβ25−35‐Induced Cell Injury
    Hexingzi Cheng, Anping Li, Pei Yang, Zhengchang Zhong, Hemei Liu, Liangshi Zhang, Qifeng Mo, Christophe Hano
    Journal of Food Biochemistry.2024;[Epub]     CrossRef
  • Fluorine-18-Labeled Diaryl-azines as Improved β-Amyloid Imaging Tracers: From Bench to First-in-Human Studies
    Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
    Journal of Medicinal Chemistry.2023; 66(7): 4603.     CrossRef
  • Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
    Qianling Chen, Xuebing Chen, Luyao Xu, Rui Zhang, Zhigang Li, Xia Yue, Dongfang Qiao
    Forensic Science, Medicine and Pathology.2022; 18(4): 530.     CrossRef
  • Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease
    Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun
    European Journal of Medicinal Chemistry.2022; 244: 114806.     CrossRef
  • Tubulin modifying enzymes as target for the treatment of tau-related diseases
    Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem van der Laan
    Pharmacology & Therapeutics.2021; 218: 107681.     CrossRef
  • Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring
    Wieke M. van Oostveen, Elizabeth C. M. de Lange
    International Journal of Molecular Sciences.2021; 22(4): 2110.     CrossRef
  • Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
    M.F. Santarelli, M. Scipioni, D. Genovesi, A. Giorgetti, P. Marzullo, L. Landini
    Current Pharmaceutical Design.2021; 27(16): 1878.     CrossRef
  • Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis
    Hong Yu, Bo Yuan, Qiubo Chu, Chunyue Wang, Hui Bi
    International Journal of Molecular Medicine.2019;[Epub]     CrossRef
Case Report
Cardiology and Cardiovascular Medicine
Acute upper limb ischemia in a patient with newly diagnosed paroxysmal atrial fibrillation
Dong Shin Kim, Seunghwan Kim, Hyang Ki Min, Chiwoo Song, Young Bin Kim, Sae Jong Kim, Ji Young Park, Sung Kee Ryu, Jae Woong Choi
Yeungnam Univ J Med. 2017;34(2):242-246.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.242
  • 2,685 View
  • 30 Download
AbstractAbstract PDF
Acute limb ischemia (ALI) due to an embolism is associated with high mortality rate and poor prognosis, and early diagnosis with prompt revascularization is required to reduce the risk of limb amputation or even death. The etiologies of ALI are diverse, and it includes an embolism from the heart and thrombotic occlusion of the atherosclerotic native vessels, stents, or grafts. An uncommon cause of ALI is acute arterial thromboembolism, and atrial fibrillation (AF) is the single most important risk factors for systemic thromboembolism. It is important to correctly identify the source of ALI for secondary prevention, as it depends on the underlying cause. Percutaneous transluminal angioplasty (PTA) has been proven to be a safe and effective treatment for focal atherosclerotic and thrombotic occlusive diseases of the aorta and its major extremity branches. Herein, we report on a 77-year-old female patient with acute upper limb ischemia, treated by PTA using a catheter-guided thrombectomy. He was newly diagnosed with paroxysmal AF (PAF) while evaluation the cause of his acute arterial thromboembolism. We recommend that cardiologists always consider PAF as a possible diagnosis even in patients without any history of AF under ALI because it is possible to develop thromboembolism in clinical practice.
Original Article
Anatomy
Developing a new index to assess varicella outbreak
Kiwook Yang, Incheol Seo
Yeungnam Univ J Med. 2017;34(2):222-230.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.222
  • 2,795 View
  • 12 Download
AbstractAbstract PDF
BACKGROUND
Varicella is the most common infectious disease reported despite the high vaccination rate. Interventions that target humans are particularly effective for varicella because humans are its only natural host. On the other hand, the existing national varicella surveillance systems lack the information to identify an outbreak. Therefore, a new index to assess varicella outbreaks was developed. METHODS: The residential addresses of 2,718 varicella cases reported in Daegu in 2016 were converted to geographic coordinates and the distances between new varicella case and previous cases within 21 days were calculated from the date analyzed. Two cases were considered to be adjacent if the distance between them was less than 1 km. Finally, a proximity index was introduced by dividing the number of adjacent cases by the number of new cases on the date analyzed. RESULTS: First, time-series charts and scatter plots were used to verify that the proximity index reflected the spatial closeness of the different varicella cases. The proximity index is helpful in identifying outbreaks from a list of single varicella cases. In addition, in this study, a new epidemic characteristic of varicella based on the proximity index was shown. CONCLUSION: The proximity index introduced in this study can be used to determine the likelihood of an outbreak from a single case of varicella, and it can be embedded in a web-based national varicella surveillance system that is currently in operation.
Review
Surgery
Surgical treatment of perianal fistula in Crohn's disease
Sohyun Kim
Yeungnam Univ J Med. 2017;34(2):169-173.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.169
  • 2,468 View
  • 16 Download
AbstractAbstract PDF
Perianal Crohn's disease is a major problem that impair quality of life. This article reviews the current surgical treatment of Crohn's perianal fistula. Fistulotomy and loose seton are commonly used surgical methods for treatment of perianal Crohn's disease. Mucosal advancement flap and fibrin glue are used in this treatment, despite a lake of controlled trials. Fecal diversion is disturbingly high in complicated complex perianal fistula in Crohn's disease. Ligation of intersphincteric fistula and autologous or allogenic stem cells are new surgical procedures for treatment of Crohn's disease that need further studies. Treatment success might be improved by multimodal treatment and new surgical and medical treatment options.
Case Reports
Cardiology and Cardiovascular Medicine
Severe chest pain with mid-ventricular obstruction in a patient with hyperthyroidism
Jong Ho Nam, Jang Won Son, Geu Ru Hong
Yeungnam Univ J Med. 2017;34(1):128-131.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.128
  • 2,277 View
  • 7 Download
AbstractAbstract PDF
Mid-ventricular obstruction (MVO) rarely occurs in patients without hypertrophic cardiomyopathy. Increased cardiac contractility may play an important role in causing MVO. We experienced a case of severe chest pain and MVO in a 50-year-old female patient. She had hypertension, diabetes, stroke and peripheral artery disease. Her blood pressure was very high (222/122 mmHg) with severe fluctuation. The transthoracic echocardiography revealed MVO accompanied by hyper-dynamic left ventricular systolic function. We regarded her chest pain and MVO as secondary findings related to other diseases. Coronary angiography and several tests for uncontrolled hypertension were performed, and those evaluations revealed that she had coronary artery disease and hyperthyroidism. We considered that the increase in the myocardial oxygen demand in response to the increase in cardiac contractility and workload associated with hyperthyroidism aggravated her symptoms and MVO. She was treated with methimazole and beta blockers and her symptoms dramatically improved.
Cardiology and Cardiovascular Medicine
Acute myocardial infarction with a giant left main aneurysm in atypical Kawasaki disease
Min Wook Kim, Hyun Soo Kim, Myung Dong Lee, Hyun Sook Jung, Seong Bo Yoon, Young Woo Kim
Yeungnam Univ J Med. 2017;34(1):106-110.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.106
  • 2,726 View
  • 8 Download
AbstractAbstract PDF
Kawasaki disease (KD) is an acute vasculitis of small and medium sized arteries. Even many years after onset, aneurysms and stenosis in coronary arteries may lead to an acute myocardial infarction, which is described as atypical or missed KD in childhood. KD is an underlying disease of young adults with acute myocardial infarction. We report on a rare case involving a total occlusion in the proximal left anterior descending coronary artery combined with a giant left main aneurysm in a young adult patient with acute myocardial infarction ascribed to antecedent KD that is undefined but almost certain.
JYMS : Journal of Yeungnam Medical Science
© Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science.
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